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Ppp1r9a protein phosphatase 1, regulatory subunit 9A [ Rattus norvegicus (Norway rat) ]

Gene ID: 84685, updated on 2-Nov-2024

Summary

Official Symbol
Ppp1r9aprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 9Aprovided by RGD
Primary source
RGD:632280
See related
EnsemblRapid:ENSRNOG00000008869 AllianceGenome:RGD:632280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Neb1; p180; PP1bp175
Summary
Enables several functions, including actin filament binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament organization; and regulation of synapse organization. Acts upstream of or within neuron projection development. Located in several cellular components, including dendritic spine neck; growth cone lamellipodium; and neuromuscular junction. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Used to study transient cerebral ischemia. Biomarker of hepatocellular carcinoma. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 210.6), Testes (RPKM 72.0) and 7 other tissues See more
Orthologs
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Genomic context

See Ppp1r9a in Genome Data Viewer
Location:
4q21
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (33936949..34258927)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (32970501..33292360)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (29976485..30247371)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene cytoskeleton-associated protein 2, pseudogene 1 Neighboring gene paraoxonase 1 Neighboring gene paraoxonase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of spontaneous neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse structural plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine neck IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neurabin-1
Names
actin-binding protein neurabin
neurabin-I
neural tissue-specific F-actin-binding protein I
protein phosphatase 1, regulatory (inhibitor) subunit 9A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401497.1NP_001388426.1  neurabin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000078577.3, ENSRNOT00000104466.3
    Conserved Domains (4) summary
    cd09512
    Location:12081277
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  2. NM_053473.3NP_445925.1  neurabin-1 isoform 2

    See identical proteins and their annotated locations for NP_445925.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    O35867
    UniProtKB/TrEMBL
    A6IDS9
    Conserved Domains (4) summary
    cd09512
    Location:9831052
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cd00992
    Location:506589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    33936949..34258927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108474.2XP_038964402.1  neurabin-1 isoform X1

    Conserved Domains (4) summary
    cd09512
    Location:12081277
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  2. XM_063286778.1XP_063142848.1  neurabin-1 isoform X10

  3. XM_063286768.1XP_063142838.1  neurabin-1 isoform X2

    UniProtKB/TrEMBL
    A6IDS7
  4. XM_063286775.1XP_063142845.1  neurabin-1 isoform X8

  5. XM_063286770.1XP_063142840.1  neurabin-1 isoform X4

    Related
    ENSRNOP00000098611.2, ENSRNOT00000121068.2
  6. XM_063286772.1XP_063142842.1  neurabin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZL80
  7. XM_063286780.1XP_063142850.1  neurabin-1 isoform X11

  8. XM_006236058.5XP_006236120.1  neurabin-1 isoform X1

    See identical proteins and their annotated locations for XP_006236120.1

    Conserved Domains (4) summary
    cd09512
    Location:12081277
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  9. XM_039108475.2XP_038964403.1  neurabin-1 isoform X2

    UniProtKB/TrEMBL
    A6IDS7
    Conserved Domains (5) summary
    cd09512
    Location:12001269
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09730
    Location:606752
    BicD; Microtubule-associated protein Bicaudal-D
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  10. XM_039108479.2XP_038964407.1  neurabin-1 isoform X7

    Related
    ENSRNOP00000011756.5, ENSRNOT00000011756.7
    Conserved Domains (5) summary
    cd09512
    Location:10051074
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cd00992
    Location:506589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09730
    Location:606752
    BicD; Microtubule-associated protein Bicaudal-D
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  11. XM_039108480.2XP_038964408.1  neurabin-1 isoform X8

    Conserved Domains (5) summary
    cd09512
    Location:9971066
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cd00992
    Location:506589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09730
    Location:606752
    BicD; Microtubule-associated protein Bicaudal-D
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  12. XM_039108476.2XP_038964404.1  neurabin-1 isoform X3

    Conserved Domains (4) summary
    cd09512
    Location:11901259
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:704819
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  13. XM_039108477.2XP_038964405.1  neurabin-1 isoform X4

    Conserved Domains (4) summary
    cd09512
    Location:11861255
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:659898
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  14. XM_039108481.2XP_038964409.1  neurabin-1 isoform X9

    UniProtKB/Swiss-Prot
    O35867
    UniProtKB/TrEMBL
    A6IDS9
    Related
    ENSRNOP00000098612.2, ENSRNOT00000121069.2
    Conserved Domains (4) summary
    cd09512
    Location:9831052
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cd00992
    Location:506589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02168
    Location:659904
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  15. XM_063286773.1XP_063142843.1  neurabin-1 isoform X6

  16. XM_063286779.1XP_063142849.1  neurabin-1 isoform X11

  17. XM_017592928.3XP_017448417.1  neurabin-1 isoform X1

    Conserved Domains (4) summary
    cd09512
    Location:12081277
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00228
    Location:502593
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    TIGR02168
    Location:681920
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17817
    Location:435498
    PDZ_5; PDZ domain
  18. XM_063286771.1XP_063142841.1  neurabin-1 isoform X4

  19. XM_063286777.1XP_063142847.1  neurabin-1 isoform X9

    UniProtKB/Swiss-Prot
    O35867
    UniProtKB/TrEMBL
    A6IDS9
  20. XM_063286774.1XP_063142844.1  neurabin-1 isoform X6

RNA

  1. XR_005503322.2 RNA Sequence