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POM33 nucleoporin POM33 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850637, updated on 28-Oct-2024

Summary

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Official Symbol
POM33
Official Full Name
nucleoporin POM33
Primary source
SGD:S000003946
Locus tag
YLL023C
See related
AllianceGenome:SGD:S000003946; FungiDB:YLL023C; VEuPathDB:YLL023C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in nuclear pore localization and nuclear pore organization. Located in endoplasmic reticulum. Part of nuclear pore. Is active in nuclear envelope. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See POM33 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (97997..98836, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU17 Neighboring gene Hsp70 family chaperone SSA2 Neighboring gene Hif1p Neighboring gene Spa2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence of 32b on the left arm of yeast chromosome XII reveals six known genes, a new member of the seripauperins family and a new ABS transporter homologous to the human multidrug resistance protein. Purnelle B, et al. Yeast, 1997 Feb. PMID 9046100
  2. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
  3. Distribution of Proteins at the Inner Nuclear Membrane Is Regulated by the Asi1 E3 Ligase in Saccharomyces cerevisiae. Smoyer CJ, et al. Genetics, 2019 Apr. PMID 30709848, Free PMC Article
  4. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Casey AK, et al. Mol Biol Cell, 2015 Aug 1. PMID 26041935, Free PMC Article
  5. Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis. Zhang W, et al. J Cell Biol, 2018 Mar 5. PMID 29439116, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear outer membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoporin POM33
NP_013077.1
  • Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    97997..98836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181843.1 → NP_013077.1  TPA: nucleoporin POM33 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXY1, Q12164
    UniProtKB/TrEMBL
    A7A0N4, B5VMS3, N1NYK9
    Conserved Domains (1) summary
    pfam03661
    Location:19 → 264
    UPF0121; Uncharacterized protein family (UPF0121)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12164.1

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