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OCA6 protein-tyrosine-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851639, updated on 2-Nov-2024

Summary

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Official Symbol
OCA6
Official Full Name
protein-tyrosine-phosphatase
Primary source
SGD:S000002474
Locus tag
YDR067C
See related
AllianceGenome:SGD:S000002474; FungiDB:YDR067C; VEuPathDB:YDR067C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OCA6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (582791..583465, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rrg1p Neighboring gene putative protein-serine/threonine phosphatase Neighboring gene Dos2p Neighboring gene ubiquitin-specific protease DOA4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae. Strawn G, et al. Microb Cell Fact, 2024 Jan 29. PMID 38287338, Free PMC Article
  2. Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Tan SX, et al. Mol Biol Cell, 2009 Mar. PMID 19129474, Free PMC Article
  3. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Romá-Mateo C, et al. Mol Genet Genomics, 2011 Apr. PMID 21409566
  4. Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Kushner DB, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14671320, Free PMC Article
  5. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Armakola M, et al. Nat Genet, 2012 Dec. PMID 23104007, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-tyrosine-phosphatase
NP_010352.1
  • Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    582791..583465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180375.1 → NP_010352.1  TPA: protein-tyrosine-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010352.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS53, Q12454, Q6Q559
    UniProtKB/TrEMBL
    A6ZY32, B3LGK3, C7GVR9, C8Z4Y5, G2WAH1, N1P4L8
    Conserved Domains (1) summary
    cd17663
    Location:4 → 181
    PFA-DSP_Oca6; atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12454.1

Gene LinkOut

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