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VBA4 Vba4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851697, updated on 2-Nov-2024

Summary

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Official Symbol
VBA4
Official Full Name
Vba4p
Primary source
SGD:S000002526
Locus tag
YDR119W
See related
AllianceGenome:SGD:S000002526; FungiDB:YDR119W; VEuPathDB:YDR119W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable basic amino acid transmembrane transporter activity. Predicted to be involved in basic amino acid transport and transmembrane transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VBA4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (688227..690533)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tma64p Neighboring gene anaphase promoting complex subunit 4 Neighboring gene Cox26p Neighboring gene tRNA (guanine26-N2)-dimethyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Biosci Biotechnol Biochem, 2016. PMID 26325352
  2. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
  3. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article
  4. Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. Coelho MC, et al. Nature, 2019 Feb. PMID 30700905, Free PMC Article
  5. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vba4p is a vacuolar membrane protein that is involved in the drug resistance and vacuolar morphology in Saccharomyces cerevisiae.
    Title: Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables basic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vba4p
NP_010404.1
  • hypothetical protein; proposed role as basic amino acid permease based on phylogeny; targeted to vacuole via AP-3 pathway; physical interaction with Atg27p suggests possible role in autophagy; non-essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    688227..690533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180427.1 → NP_010404.1  TPA: Vba4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSA4, Q04602
    UniProtKB/TrEMBL
    C7GIM6, N1P877
    Conserved Domains (1) summary
    cl28910
    Location:259 → 414
    MFS; Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04602.1

Gene LinkOut

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