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SEC26 coatomer subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 851824, updated on 2-Nov-2024

Summary

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Official Symbol
SEC26
Official Full Name
coatomer subunit beta
Primary source
SGD:S000002646
Locus tag
YDR238C
See related
AllianceGenome:SGD:S000002646; FungiDB:YDR238C; VEuPathDB:YDR238C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable structural molecule activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular mRNA localization. Part of COPI vesicle coat. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEC26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (937895..940816, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene riboflavin kinase Neighboring gene mitochondrial 54S ribosomal protein YmL7/YmL5 Neighboring gene uncharacterized protein Neighboring gene Snu56p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. DeRegis CJ, et al. BMC Cell Biol, 2008 Jan 22. PMID 18211691, Free PMC Article
  2. Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Hoffman GR, et al. Mol Cell, 2003 Sep. PMID 14527408
  3. An Essential Role for COPI in mRNA Localization to Mitochondria and Mitochondrial Function. Zabezhinsky D, et al. Cell Rep, 2016 Apr 19. PMID 27068463
  4. Effects of mutations in the WD40 domain of α-COP on its interaction with the COPI coatomer in Saccharomyces cerevisiae. Kim KH, et al. J Microbiol, 2012 Apr. PMID 22538654
  5. Coupled ER to Golgi transport reconstituted with purified cytosolic proteins. Barlowe C. J Cell Biol, 1997 Dec 1. PMID 9382859, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit beta
NP_010524.3
  • Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    937895..940816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180546.3 → NP_010524.3  TPA: coatomer subunit beta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010524.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSL9, P41810, Q03779
    UniProtKB/TrEMBL
    A6ZYJ1, C8Z5E9, G2WAY2, N1P518
    Conserved Domains (1) summary
    COG5096
    Location:1 → 941
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41810.2

Gene LinkOut

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