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KXD1 Kxd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852801, updated on 17-May-2024

Summary

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Gene symbol
KXD1
Gene description
Kxd1p
Primary source
FungiDB:YGL079W
Locus tag
YGL079W
See related
SGD:S000003047; AllianceGenome:SGD:S000003047; VEuPathDB:YGL079W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endosome organization and regulation of protein localization. Located in endosome. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KXD1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (359444..360100)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pyruvate transporter MPC1 Neighboring gene RNA-dependent ATPase DBP3 Neighboring gene Hnm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. Norambuena L, et al. BMC Chem Biol, 2008 Jan 7. PMID 18179719, Free PMC Article
  2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
  3. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
  4. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article
  5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BLOC-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kxd1p
NP_011436.1
  • Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    359444..360100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180944.1 → NP_011436.1  TPA: Kxd1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZUA0, B3LHE5, B5VIP5, C8Z8G8, D6VU65, E7KCH3, E7KNF7, E7LUC9, E7NHM9, E7Q3U6, P53158
    UniProtKB/TrEMBL
    A0A6A5PWJ5, G2WE20, N1P365
    Conserved Domains (1) summary
    pfam10241
    Location:115 → 193
    KxDL; Uncharacterized conserved protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53158.1

Gene LinkOut

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