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MRH4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852816, updated on 22-Aug-2024

Summary

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Official Symbol
MRH4
Primary source
FungiDB:YGL064C
Locus tag
YGL064C
See related
SGD:S000003032; AllianceGenome:SGD:S000003032; VEuPathDB:YGL064C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA helicase activity and mitochondrial ribosomal large subunit rRNA binding activity. Involved in RNA metabolic process and mitochondrial large ribosomal subunit assembly. Located in mitochondrial matrix. Orthologous to human DDX28 (DEAD-box helicase 28). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MRH4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (381523..383208, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene deubiquitination module subunit SGF73 Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene pseudouridine synthase PUS2 Neighboring gene pyruvate carboxylase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel mitochondrial DEAD box protein (Mrh4) required for maintenance of mtDNA in Saccharomyces cerevisiae. Schmidt U, et al. FEMS Yeast Res, 2002 Aug. PMID 12702275
  2. The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit. De Silva D, et al. Cell Metab, 2013 Nov 5. PMID 24206665, Free PMC Article
  3. The sequence of a 36.7 kb segment on the left arm of chromosome IV from Saccharomyces cerevisiae reveals 20 non-overlapping open reading frames (ORFs) including SIT4, FAD1, NAM1, RNA11, SIR2, NAT1, PRP9, ACT2 and MPS1 and 11 new ORFs. Sarén AM, et al. Yeast, 1997 Jan. PMID 9046088
  4. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
  5. The DEAD-box helicase Mss116 plays distinct roles in mitochondrial ribogenesis and mRNA-specific translation. De Silva D, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28520979, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial ribosomal large subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial large ribosomal subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase
NP_011451.1
  • Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    381523..383208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180929.1 → NP_011451.1  TPA: ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZUB2, D6VU77, P53166
    UniProtKB/TrEMBL
    B3LHD3, C7GW46, C8Z8I2, N1P3K8
    Conserved Domains (2) summary
    COG0513
    Location:137 → 560
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17965
    Location:100 → 346
    DEADc_MRH4; DEAD-box helicase domain of ATP-dependent RNA helicase MRH4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53166.1

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