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MRPL25 mitochondrial 54S ribosomal protein YmL25 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852967, updated on 2-Nov-2024

Summary

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Official Symbol
MRPL25
Official Full Name
mitochondrial 54S ribosomal protein YmL25
Primary source
SGD:S000003308
Locus tag
YGR076C
See related
AllianceGenome:SGD:S000003308; FungiDB:YGR076C; VEuPathDB:YGR076C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AFO1; mL59; YMR26
Summary
A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRPL25 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (637104..637577, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Upf3p Neighboring gene mRNA splicing protein SMD1 Neighboring gene U4/U6-U5 snRNP complex subunit PRP38 Neighboring gene Pex8p Neighboring gene tubulin-binding prefolding complex subunit PAC10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and analysis of YMR26, the nuclear gene for a mitochondrial ribosomal protein in Saccharomyces cerevisiae. Kang W, et al. Mol Gen Genet, 1991 Mar. PMID 2017142
  2. Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1(-) Yeast Suppressed by a Dominant Mutation in ATP3. Li J, et al. G3 (Bethesda), 2020 Dec 3. PMID 33093184, Free PMC Article
  3. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Rinnerthaler M, et al. Proc Natl Acad Sci U S A, 2012 May 29. PMID 22586098, Free PMC Article
  4. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Heeren G, et al. Aging (Albany NY), 2009 Jul 13. PMID 20157544, Free PMC Article
  5. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. Kaur J, et al. EMBO Rep, 2011 Sep 1. PMID 21779004, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AFO1/MRPL25 function establishes a new connection between mitochondria, metabolism and aging.
    Title: The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial 54S ribosomal protein YmL25
NP_011590.1
  • Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    637104..637577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181205.1 → NP_011590.1  TPA: mitochondrial 54S ribosomal protein YmL25 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011590.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUK8, P23369
    UniProtKB/TrEMBL
    A6ZV58, B3LIF0, C7GXQ5, C8Z8X0, G2WEG0, N1P5S8
    Conserved Domains (1) summary
    pfam18126
    Location:13 → 138
    Mitoc_mL59; Mitochondrial ribosomal protein mL59
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23369.2

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