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GPI14 glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I [ Saccharomyces cerevisiae S288C ]

Gene ID: 853470, updated on 18-Sep-2024

Summary

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Official Symbol
GPI14
Official Full Name
glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I
Primary source
SGD:S000003774
Locus tag
YJR013W
See related
AllianceGenome:SGD:S000003774; FungiDB:YJR013W; VEuPathDB:YJR013W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PMH1
Summary
Contributes to mannosyltransferase activity. Involved in GPI anchor biosynthetic process and fungal-type cell wall organization. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-mannosyltransferase I complex. Orthologous to human PIGM (phosphatidylinositol glycan anchor biosynthesis class M). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GPI14 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (460382..461593)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Cal4p Neighboring gene uncharacterized protein Neighboring gene Tma22p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast. Kim YU, et al. J Biochem, 2007 Jul. PMID 17519279
  2. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. Maeda Y, et al. EMBO J, 2001 Jan 15. PMID 11226175, Free PMC Article
  3. Characterization of GPI14/YJR013w mutation that induces the cell wall integrity signalling pathway and results in increased protein production in Saccharomyces cerevisiae. Davydenko SG, et al. Yeast, 2005 Sep. PMID 16134120
  4. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
  5. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Shimada K, et al. Mol Cell, 2013 Sep 26. PMID 24035500

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,4-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycolipid mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GPI anchor biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of glycosylphosphatidylinositol-mannosyltransferase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-mannosyltransferase I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I
NP_012547.2
  • Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    460382..461593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181671.1 → NP_012547.2  TPA: glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012547.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWI9, E9P8R4, P47088
    UniProtKB/TrEMBL
    B3LQB2, D3UF77, G2WH25, N1P1H3
    Conserved Domains (1) summary
    pfam05007
    Location:127 → 386
    Mannosyl_trans; Mannosyltransferase (PIG-M)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47088.2

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