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NEO1 putative aminophospholipid-translocating P4-type ATPase NEO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854763, updated on 18-Sep-2024

Summary

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Official Symbol
NEO1
Official Full Name
putative aminophospholipid-translocating P4-type ATPase NEO1
Primary source
SGD:S000001310
Locus tag
YIL048W
See related
AllianceGenome:SGD:S000001310; FungiDB:YIL048W; VEuPathDB:YIL048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including phospholipid translocation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vacuole organization. Located in Golgi membrane; late endosome; and trans-Golgi network. Colocalizes with COPI-coated vesicle. Orthologous to human ATP9A (ATPase phospholipid transporting 9A (putative)) and ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NEO1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (261437..264892)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Pcl7p Neighboring gene putative polyprenol reductase Neighboring gene Syg1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an overexpressed yeast gene which prevents aminoglycoside toxicity. Prezant TR, et al. Microbiology (Reading), 1996 Dec. PMID 9004503
  2. Identification and phylogenetic classification of eleven putative P-type calcium transport ATPase genes in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Catty P, et al. Biosci Rep, 1996 Apr. PMID 8790914
  3. Structural basis of the P4B ATPase lipid flippase activity. Bai L, et al. Nat Commun, 2021 Oct 13. PMID 34645814, Free PMC Article
  4. Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae. Huang Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Feb. PMID 31786280, Free PMC Article
  5. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network. Zhao SB, et al. Biochim Biophys Acta Gen Subj, 2019 Jun. PMID 30981741

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of the P4B ATPase lipid flippase activity.
    Title: Structural basis of the P4B ATPase lipid flippase activity.
  2. The Any1 coimmunoprecipitates with Neo1, an association prevented by the Any1-inactivating mutation D84G.
    Title: The PQ-loop protein Any1 segregates Drs2 and Neo1 functions required for viability and plasma membrane phospholipid asymmetry.
  3. Study found that residues critical for phospholipid substrate recognition in P4A-ATPases from yeast to man are essential for function of an evolutionarily distant P4B-ATPase Neo1 from Saccharomyces cerevisiae.
    Title: Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae.
  4. These results indicate that Neo1 plays an important role in establishing PS and PE plasma membrane asymmetry in budding yeast.
    Title: The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane.
  5. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
    Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine flippase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine floppase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminophospholipid translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative aminophospholipid-translocating P4-type ATPase NEO1
NP_012216.1
  • Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and Golgi apparatus; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    261437..264892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179398.1 → NP_012216.1  TPA: putative aminophospholipid-translocating P4-type ATPase NEO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN3, P40527
    UniProtKB/TrEMBL
    A6ZVM1, B3LTQ4, B5VKP8, C7GVX6, C8ZAJ8, G2WG97, N1P436
    Conserved Domains (2) summary
    cd07541
    Location:172 → 1067
    P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
    pfam13246
    Location:574 → 670
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40527.1

Gene LinkOut

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