U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIG2 putative protein phosphatase regulator PIG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854766, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PIG2
Official Full Name
putative protein phosphatase regulator PIG2
Primary source
SGD:S000001307
Locus tag
YIL045W
See related
AllianceGenome:SGD:S000001307; FungiDB:YIL045W; VEuPathDB:YIL045W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein phosphatase regulator activity. Involved in regulation of glycogen biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PPP1R3B (protein phosphatase 1 regulatory subunit 3B); and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PIG2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (271161..272777)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 Neighboring gene GTPase-activating protein AGE2 Neighboring gene cytochrome-b5 reductase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
  2. Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Williams-Hart T, et al. Genetics, 2002 Apr. PMID 11973298, Free PMC Article
  3. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Castermans D, et al. Cell Res, 2012 Jun. PMID 22290422, Free PMC Article
  4. The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Tronnersjö S, et al. Mol Genet Genomics, 2007 Jan. PMID 17043893
  5. Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Wilson WA, et al. Mol Cell Proteomics, 2002 Mar. PMID 12096123

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycogen biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative protein phosphatase regulator PIG2
NP_012219.3
  • Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    271161..272777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179395.3 → NP_012219.3  TPA: putative protein phosphatase regulator PIG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012219.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN7, E9P960, P40187
    UniProtKB/TrEMBL
    A6ZVM4, B3LTQ1, B5VKQ2, N1P950
    Conserved Domains (1) summary
    pfam03370
    Location:388 → 508
    CBM_21; Carbohydrate/starch-binding module (family 21)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40187.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous