putative cystathionine gamma-synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Full Name: putative cystathionine gamma-synthase
Primary source: SGD:S000004547
Locus tag: YML082W
See related: AllianceGenome:SGD:S000004547; FungiDB:YML082W; VEuPathDB:YML082W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable carbon-sulfur lyase activity and cystathionine gamma-synthase activity. Predicted to be involved in transsulfuration. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (101862..103811)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carbon-sulfur lyase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cystathionine gamma-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-synthase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sulfur compound metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: putative cystathionine gamma-synthase

NP_013628.1

EC 2.5.1.48

Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

101862..103811

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182441.1 → NP_013628.1 TPA: putative cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0K0, Q04533

UniProtKB/TrEMBL

B3LLH3, G2WJX2, N1NYX4

Conserved Domains (1) summary

COG0626
Location:227 → 645

MetC; Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]