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UME1 Ume1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855964, updated on 18-Sep-2024

Summary

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Official Symbol
UME1
Official Full Name
Ume1p
Primary source
SGD:S000006060
Locus tag
YPL139C
See related
AllianceGenome:SGD:S000006060; FungiDB:YPL139C; VEuPathDB:YPL139C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WTM3
Summary
Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase I; positive regulation of transcription by RNA polymerase II; and regulation of meiotic nuclear division. Located in cytoplasm and nucleus. Part of Rpd3L complex and Rpd3S/Clr6-CII complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UME1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (289669..291051, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein kinase FRK1 Neighboring gene putative mitogen-activated protein kinase kinase MKK2 Neighboring gene Spp1p Neighboring gene protein phosphatase regulator GIP3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Local statistics allow quantification of cell-to-cell variability from high-throughput microscope images. Handfield LF, et al. Bioinformatics, 2015 Mar 15. PMID 25398614, Free PMC Article
  2. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton LF, et al. Mol Cell Biol, 1997 Aug. PMID 9234739, Free PMC Article
  3. Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Strich R, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2690066, Free PMC Article
  4. Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. Mallory MJ, et al. J Biol Chem, 2003 Nov 7. PMID 12954623
  5. Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex. Ruan C, et al. J Biol Chem, 2016 Mar 4. PMID 26747610, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L complex HDA PubMed 
part_of Rpd3L complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex HDA PubMed 
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3S complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ume1p
NP_015186.1
  • Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    289669..291051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183953.1 → NP_015186.1  TPA: Ume1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015186.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3M9, P87330, Q03010
    UniProtKB/TrEMBL
    A6ZWB4, B3LKT7, B5VT27, C7GJ91, C8ZIP0, N1NVV2
    Conserved Domains (2) summary
    COG2319
    Location:1 → 445
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:243 → 274
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03010.1

Gene LinkOut

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