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NOC4 ribosome biosynthesis protein NOC4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856267, updated on 29-Jun-2024

Summary

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Gene symbol
NOC4
Gene description
ribosome biosynthesis protein NOC4
Primary source
FungiDB:YPR144C
Locus tag
YPR144C
See related
SGD:S000006348; AllianceGenome:SGD:S000006348; VEuPathDB:YPR144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UTP19
Summary
Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytosol and nucleolus. Part of Noc4p-Nop14p complex and small-subunit processome. Orthologous to human NOC4L (nucleolar complex associated 4 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NOC4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (819765..821423, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rrp15p Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene asparagine synthase (glutamine-hydrolyzing) 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome. Kühn H, et al. PLoS One, 2009 Dec 18. PMID 20019888, Free PMC Article
  2. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article
  3. 90S pre-ribosome transformation into the primordial 40S subunit. Cheng J, et al. Science, 2020 Sep 18. PMID 32943521
  4. Eukaryotic nuclear structure explains the evolutionary rate difference of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Sep 15. PMID 18588954
  5. Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis. Léger-Silvestre I, et al. J Biol Chem, 2005 Nov 18. PMID 16159874

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The essential C-terminus of Noc4p is required and sufficient for its association with Nop14p and several nuclear precursors of the small ribosomal subunit.
    Title: The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of Noc4p-Nop14p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc4p-Nop14p complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosome biosynthesis protein NOC4
NP_015470.1
  • Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    819765..821423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184241.1 → NP_015470.1  TPA: ribosome biosynthesis protein NOC4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015470.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4E1, Q06512
    UniProtKB/TrEMBL
    A0A6A5Q392, A6ZX20, B3LKA4, B5VTT0, C7GXT1, C8ZJG7, G2WPV7, N1NVL7
    Conserved Domains (1) summary
    pfam03914
    Location:317 → 481
    CBF; CBF/Mak21 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06512.1

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