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YHK8 Yhk8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856444, updated on 28-Oct-2024

Summary

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Official Symbol
YHK8
Official Full Name
Yhk8p
Primary source
SGD:S000001090
Locus tag
YHR048W
See related
AllianceGenome:SGD:S000001090; FungiDB:YHR048W; VEuPathDB:YHR048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in cell periphery. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See YHK8 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (204607..206151)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene inositol monophosphate 1-phosphatase INM1 Neighboring gene arginine/alanine aminopeptidase Neighboring gene putative serine hydrolase Neighboring gene divalent metal ion transporter SMF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Goffeau A, et al. Yeast, 1997 Jan. PMID 9046086
  2. Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae. Barker KS, et al. J Antimicrob Chemother, 2003 May. PMID 12697649
  3. Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycetous yeasts. Dias PJ, et al. OMICS, 2010 Dec. PMID 21114408
  4. FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation. Leng H, et al. Nucleic Acids Res, 2021 Jun 4. PMID 33963860, Free PMC Article
  5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Yhk8p
NP_011914.1
  • Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    204607..206151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179178.1 → NP_011914.1  TPA: Yhk8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011914.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKZ6, P38776
    UniProtKB/TrEMBL
    A6ZSV5, B5VJX9, C7GT87, C8ZAB9, N1P9M5
    Conserved Domains (1) summary
    cd17323
    Location:77 → 505
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38776.1

Gene LinkOut

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