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EIF2B4 eukaryotic translation initiation factor 2B subunit delta [ Homo sapiens (human) ]

Gene ID: 8890, updated on 2-Nov-2024

Summary

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Official Symbol
EIF2B4provided by HGNC
Official Full Name
eukaryotic translation initiation factor 2B subunit deltaprovided by HGNC
Primary source
HGNC:HGNC:3260
See related
Ensembl:ENSG00000115211 MIM:606687; AllianceGenome:HGNC:3260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VWM4; EIF2B; EIF-2B; EIF2Bdelta
Summary
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 20.0), prostate (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF2B4 in Genome Data Viewer
Location:
2p23.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27364352..27370338, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27406760..27412735, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27587219..27593205, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27543343-27543946 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27545801-27546773 Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene GTF3C2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:27579025-27579638 and GRCh37_chr2:27579639-27580252 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27582391-27583132 Neighboring gene GTF3C2 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27592451-27593412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27593413-27594374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27601343-27602213 Neighboring gene sorting nexin 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11297 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene ferritin heavy chain 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. Kobayashi H, et al. Am J Physiol Endocrinol Metab, 2003 Mar. PMID 12556349
  2. Acute neurological deterioration in ovarioleukodystrophy related to EIF2B mutations: pregnancy with oocyte donation is a potentially precipitating factor. Peter L, et al. Eur J Neurol, 2008 Jan. PMID 18005052
  3. A case of ovarioleukodystrophy without eIF2B mutations. Gaudiano C, et al. J Neurol Sci, 2008 May 15. PMID 18061208
  4. A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Wang X, et al. Mol Cell Biol, 2008 Mar. PMID 18160716, Free PMC Article
  5. Vanishing white matter disease: the first reported chinese patient. Wong SS, et al. J Child Neurol, 2008 Jun. PMID 18539998

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leukodystrophy Due to eIF2B Mutations in Adults.
    Title: Leukodystrophy Due to eIF2B Mutations in Adults.
  2. A novel missense mutation within EIF2B4 is associated with vanishing white matter disease.
    Title: Adult-onset vanishing white matter disease with novel missense mutations in a subunit of translational regulator, EIF2B4.
  3. demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs
    Title: DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.
  4. The functional effects of selected vanishing white matter disease mutations in EIF2B2-5 by coexpressing mutated and wild-type subunits in human cells.
    Title: Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.
  5. analysis of developmental splicing deregulation in leukodystrophies related to EIF2B mutations
    Title: Developmental splicing deregulation in leukodystrophies related to EIF2B mutations.
  6. A mutation .626G>A [p.Arg209Gln] in exon 7 and c.1399C>T [p.Arg467Trp] in exon 13 of the EIF2B4-Gens.
    Title: [Vanishing white matter disease: a stress-related leukodystrophy].
  7. Data demonstrate that cellular response resulting from eIF2alpha phosphorylation is attenuated in several cancer cell lines, and correlates with the expression of a specific isoform of a regulatory eIF2B subunit, eIF2Bdelta variant 1 (V1).
    Title: Regulation of the unfolded protein response by eif2Bdelta isoforms.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
  9. These results validate the measurement of eIF2B GEF activity in patients' transformed-lymphocytes as an important tool for the diagnosis of eIF2B-related disorders.
    Title: Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders.
  10. A unique EIF2B mutation spectrum in Chinese Vanishing white matter patients was shown.
    Title: Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 2B, subunit 4 delta (EIF2B4, 67kDa) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp586J0119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to heat TAS
Traceable Author Statement
more info
  
involved_in response to peptide hormone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 2B complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B subunit delta
Names
eIF-2B GDP-GTP exchange factor subunit delta
eIF2B GDP-GTP exchange factor subunit delta
eukaryotic translation initiation factor 2B subunit 4 delta
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
translation initiation factor eIF-2B subunit delta
translation initiation factor eIF-2b delta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009305.1 RefSeqGene

    Range
    5120..11106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001034116.2 → NP_001029288.1  translation initiation factor eIF2B subunit delta isoform 2

    See identical proteins and their annotated locations for NP_001029288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 4.
    Source sequence(s)
    AF112207, BC091502, JQ991007
    Consensus CDS
    CCDS33164.1
    UniProtKB/Swiss-Prot
    Q53RY7, Q5BJF4, Q9BUV9, Q9UBG4, Q9UI10, Q9UIQ9, Q9UJ95
    UniProtKB/TrEMBL
    Q71US4
    Related
    ENSP00000233552.6, ENST00000347454.9
    Conserved Domains (1) summary
    pfam01008
    Location:219 → 509
    IF-2B; Initiation factor 2 subunit family

  2. NM_001318965.2 → NP_001305894.1  translation initiation factor eIF2B subunit delta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC074117, AF112207, BC001870, BG717490
    Consensus CDS
    CCDS82432.1
    UniProtKB/TrEMBL
    E7ERK9, Q71US4
    Related
    ENSP00000429323.1, ENST00000493344.6
    Conserved Domains (1) summary
    pfam01008
    Location:240 → 530
    IF-2B; Initiation factor 2 subunit family

  3. NM_001318966.2 → NP_001305895.1  translation initiation factor eIF2B subunit delta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (5) is shorter at the N-terminus compared to isoform 4.
    Source sequence(s)
    AC074117, AF112207, AF218009, AK300734
    UniProtKB/TrEMBL
    Q71US4
    Conserved Domains (2) summary
    COG1184
    Location:204 → 502
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:204 → 494
    IF-2B; Initiation factor 2 subunit family

  4. NM_001318967.2 → NP_001305896.1  translation initiation factor eIF2B subunit delta isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal aa compared to isoform 4.
    Source sequence(s)
    AC074117, AF057699, AF112207, JQ991007
    UniProtKB/TrEMBL
    Q71US4
    Conserved Domains (2) summary
    COG1184
    Location:188 → 486
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:188 → 478
    IF-2B; Initiation factor 2 subunit family

  5. NM_001318968.2 → NP_001305897.1  translation initiation factor eIF2B subunit delta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice junction compared to variant 4. The resulting isoform (7) is shorter at the N-terminus compared to isoform 4.
    Source sequence(s)
    AF112207, AJ011306, BC001870, BI255289
    UniProtKB/TrEMBL
    Q9Y3W7
    Conserved Domains (2) summary
    COG1184
    Location:24 → 322
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:24 → 314
    IF-2B; Initiation factor 2 subunit family

  6. NM_001318969.2 → NP_001305898.1  translation initiation factor eIF2B subunit delta isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (8) is shorter at the N-terminus compared to isoform 4.
    Source sequence(s)
    AC074117
    UniProtKB/TrEMBL
    Q9Y3W7
    Conserved Domains (1) summary
    pfam01008
    Location:13 → 303
    IF-2B; Initiation factor 2 subunit family

  7. NM_015636.4 → NP_056451.3  translation initiation factor eIF2B subunit delta isoform 3

    See identical proteins and their annotated locations for NP_056451.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal aa compared to isoform 4.
    Source sequence(s)
    AC074117
    Consensus CDS
    CCDS46244.1
    UniProtKB/TrEMBL
    Q71US4
    Related
    ENSP00000394397.2, ENST00000445933.6
    Conserved Domains (2) summary
    COG1184
    Location:218 → 516
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:218 → 508
    IF-2B; Initiation factor 2 subunit family

  8. NM_172195.4 → NP_751945.2  translation initiation factor eIF2B subunit delta isoform 1

    See identical proteins and their annotated locations for NP_751945.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (1, also known as the "long" isoform)) has the same N- and C-termini but is 1 aa shorter compared to isoform 4.
    Source sequence(s)
    AF112207, AJ011306, BC091502
    Consensus CDS
    CCDS46245.1
    UniProtKB/TrEMBL
    Q71US4
    Related
    ENSP00000394869.2, ENST00000451130.6
    Conserved Domains (2) summary
    COG1184
    Location:239 → 537
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:239 → 529
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27364352..27370338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27406760..27412735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UI10.2 GenPept UniProtKB/Swiss-Prot:Q9UI10

Gene LinkOut

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