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OSMR oncostatin M receptor [ Homo sapiens (human) ]

Gene ID: 9180, updated on 2-Nov-2024

Summary

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Official Symbol
OSMRprovided by HGNC
Official Full Name
oncostatin M receptorprovided by HGNC
Primary source
HGNC:HGNC:8507
See related
Ensembl:ENSG00000145623 MIM:601743; AllianceGenome:HGNC:8507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta
Summary
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues See more
Orthologs
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Genomic context

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See OSMR in Genome Data Viewer
Location:
5p13.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (38846012..38945579)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (39095483..39194986)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38846114..38935743)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OSMR divergent transcript Neighboring gene transmembrane protein 126A pseudogene Neighboring gene Sharpr-MPRA regulatory region 7781 Neighboring gene uncharacterized LOC107986414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38810677-38811177 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38830048-38831247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38878837-38879338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38879339-38879838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38907734-38908234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38908235-38908735 Neighboring gene NANOG hESC enhancer GRCh37_chr5:38916726-38917255 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84767 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84768 Neighboring gene RPTOR independent companion of MTOR complex 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39011967-39012173 Neighboring gene androgen induced 1 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:39073334-39073860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:39074387-39074913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22495 Neighboring gene Sharpr-MPRA regulatory region 14991 Neighboring gene FYN binding protein 1 Neighboring gene golgin A5 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma. Kausar T, et al. Cell Oncol (Dordr), 2011 Jun. PMID 21394648
  2. Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology. Devor EJ, et al. Int J Gynecol Cancer, 2017 May. PMID 28375929, Free PMC Article
  3. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. Deng G, et al. Clin Cancer Res, 2009 Mar 1. PMID 19223499
  4. A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family. Arita K, et al. J Dermatol Sci, 2009 Jul. PMID 19375894
  5. [Identification of pathogenic mutations in two Chinese families affected with primary localized cutaneous amyloidosis]. Mao B, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2018 Feb 10. PMID 29419851

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease.
    Title: Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease.
  2. Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis.
    Title: Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis.
  3. Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
    Title: Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
  4. The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure.
    Title: The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure.
  5. OSMRbeta mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients.
    Title: OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients.
  6. Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
    Title: Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
  7. Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
    Title: Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
  8. Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.
    Title: Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.
  9. Whole-exome analysis of metaplastic breast carcinomas with extensive osseous differentiation.
    Title: Whole-exome analysis of metaplastic breast carcinomas with extensive osseous differentiation.
  10. The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling.
    Title: The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Amyloidosis, primary localized cutaneous, 1
MedGen: C4551501 OMIM: 105250 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of oncostatin M receptor (OSMR) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC75127, MGC150626, MGC150627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to oncostatin-M receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to oncostatin-M receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oncostatin-M-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of acute inflammatory response IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oncostatin-M receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oncostatin-M-specific receptor subunit beta
Names
IL-31 receptor subunit beta
IL-31R subunit beta
interleukin-31 receptor subunit beta
oncostatin-M specific receptor beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016236.2 RefSeqGene

    Range
    5002..94631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168355.3 → NP_001161827.1  oncostatin-M-specific receptor subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161827.1

    Status: REVIEWED

    Source sequence(s)
    BC010943, BM893608
    Consensus CDS
    CCDS54847.1
    UniProtKB/Swiss-Prot
    Q99650
    Related
    ENSP00000422023.1, ENST00000502536.5
    Conserved Domains (1) summary
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001323504.2 → NP_001310433.1  oncostatin-M-specific receptor subunit beta isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    BC010943, BM893608, DR006275
    Consensus CDS
    CCDS54847.1
    UniProtKB/Swiss-Prot
    Q99650
    Conserved Domains (1) summary
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001323505.2 → NP_001310434.1  oncostatin-M-specific receptor subunit beta isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC026713, AI417125, BU619548, CA439576, CB265977, U60805
    Consensus CDS
    CCDS3928.1
    UniProtKB/Swiss-Prot
    Q6P4E8, Q96QJ6, Q99650
    Conserved Domains (3) summary
    cd00063
    Location:625 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:539 → 607
    fn3; Fibronectin type III domain
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_001323506.2 → NP_001310435.1  oncostatin-M-specific receptor subunit beta isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC026713, AI417125, BU619548, CA439576, CB265977, U60805
    UniProtKB/Swiss-Prot
    Q99650
    Conserved Domains (4) summary
    smart00060
    Location:335 → 407
    FN3; Fibronectin type 3 domain
    cd00063
    Location:626 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:540 → 608
    fn3; Fibronectin type III domain
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001323507.2 → NP_001310436.1  oncostatin-M-specific receptor subunit beta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AI417125, BQ772952, U60805
    UniProtKB/Swiss-Prot
    Q99650
    Conserved Domains (2) summary
    cd00063
    Location:335 → 419
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:30 → 138
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain

  6. NM_003999.3 → NP_003990.1  oncostatin-M-specific receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_003990.1

    Status: REVIEWED

    Source sequence(s)
    BP352496, BU619548, CA439576, CB265977, DR006275, U60805
    Consensus CDS
    CCDS3928.1
    UniProtKB/Swiss-Prot
    Q6P4E8, Q96QJ6, Q99650
    Related
    ENSP00000274276.3, ENST00000274276.8
    Conserved Domains (3) summary
    cd00063
    Location:625 → 733
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:539 → 607
    fn3; Fibronectin type III domain
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    38846012..38945579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514161.3 → XP_011512463.1  oncostatin-M-specific receptor subunit beta isoform X3

    Conserved Domains (4) summary
    smart00060
    Location:335 → 407
    FN3; Fibronectin type 3 domain
    cd00063
    Location:626 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:540 → 608
    fn3; Fibronectin type III domain
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_017010019.2 → XP_016865508.1  oncostatin-M-specific receptor subunit beta isoform X4

  3. XM_047417872.1 → XP_047273828.1  oncostatin-M-specific receptor subunit beta isoform X4

  4. XM_005248384.1 → XP_005248441.1  oncostatin-M-specific receptor subunit beta isoform X1

    See identical proteins and their annotated locations for XP_005248441.1

    Conserved Domains (4) summary
    smart00060
    Location:335 → 407
    FN3; Fibronectin type 3 domain
    cd00063
    Location:626 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:540 → 608
    fn3; Fibronectin type III domain
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_005248386.3 → XP_005248443.1  oncostatin-M-specific receptor subunit beta isoform X5

    Conserved Domains (3) summary
    smart00060
    Location:335 → 407
    FN3; Fibronectin type 3 domain
    cd00063
    Location:446 → 522
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:233 → 288
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. XM_005248387.3 → XP_005248444.1  oncostatin-M-specific receptor subunit beta isoform X6

    Conserved Domains (2) summary
    cd00063
    Location:335 → 419
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:30 → 138
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain

  7. XM_047417873.1 → XP_047273829.1  oncostatin-M-specific receptor subunit beta isoform X5

  8. XM_047417870.1 → XP_047273826.1  oncostatin-M-specific receptor subunit beta isoform X1

  9. XM_047417871.1 → XP_047273827.1  oncostatin-M-specific receptor subunit beta isoform X2

    UniProtKB/Swiss-Prot
    Q6P4E8, Q96QJ6, Q99650

RNA

  1. XR_925661.1 RNA Sequence

  2. XR_007058659.1 RNA Sequence

  3. XR_007058660.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    39095483..39194986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353784.1 → XP_054209759.1  oncostatin-M-specific receptor subunit beta isoform X3

  2. XM_054353785.1 → XP_054209760.1  oncostatin-M-specific receptor subunit beta isoform X4

  3. XM_054353786.1 → XP_054209761.1  oncostatin-M-specific receptor subunit beta isoform X4

  4. XM_054353781.1 → XP_054209756.1  oncostatin-M-specific receptor subunit beta isoform X1

  5. XM_054353787.1 → XP_054209762.1  oncostatin-M-specific receptor subunit beta isoform X5

  6. XM_054353789.1 → XP_054209764.1  oncostatin-M-specific receptor subunit beta isoform X6

  7. XM_054353788.1 → XP_054209763.1  oncostatin-M-specific receptor subunit beta isoform X5

  8. XM_054353782.1 → XP_054209757.1  oncostatin-M-specific receptor subunit beta isoform X1

  9. XM_054353783.1 → XP_054209758.1  oncostatin-M-specific receptor subunit beta isoform X2

    UniProtKB/Swiss-Prot
    Q6P4E8, Q96QJ6, Q99650

RNA

  1. XR_008487195.1 RNA Sequence

  2. XR_008487196.1 RNA Sequence

  3. XR_008487197.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99650.1 GenPept UniProtKB/Swiss-Prot:Q99650

Gene LinkOut

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