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IMP4 IMP U3 small nucleolar ribonucleoprotein 4 [ Homo sapiens (human) ]

Gene ID: 92856, updated on 28-Oct-2024

Summary

Official Symbol
IMP4provided by HGNC
Official Full Name
IMP U3 small nucleolar ribonucleoprotein 4provided by HGNC
Primary source
HGNC:HGNC:30856
See related
Ensembl:ENSG00000136718 MIM:612981; AllianceGenome:HGNC:30856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BXDC4
Summary
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues See more
Orthologs
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Genomic context

See IMP4 in Genome Data Viewer
Location:
2q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130342897..130347967)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130776821..130781891)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131100470..131105540)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (anticodon TTC) 1-1 Neighboring gene coiled-coil domain containing 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11957 Neighboring gene protein tyrosine phosphatase non-receptor type 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131129403-131130030 Neighboring gene uncharacterized LOC105373618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11960

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC19606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA NAS
Non-traceable Author Statement
more info
PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Mpp10 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Mpp10 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of preribosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP4
Names
IMP4 homolog, U3 small nucleolar ribonucleoprotein
IMP4, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 4 homolog
U3 snoRNP protein IMP4
brix domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320304.2NP_001307233.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:84251
    Brix; The Brix domain is found in a number of eukaryotic proteins
  2. NM_001320305.2NP_001307234.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:84235
    Brix; The Brix domain is found in a number of eukaryotic proteins
  3. NM_001320306.2NP_001307235.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    E7ENR5, H0Y714
    Related
    ENSP00000409371.1, ENST00000452955.1
    Conserved Domains (1) summary
    smart00879
    Location:31198
    Brix; The Brix domain is found in a number of eukaryotic proteins
  4. NM_001320307.2NP_001307236.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    E7ENR5, H0Y714
    Related
    ENSP00000389701.1, ENST00000428740.5
    Conserved Domains (1) summary
    smart00879
    Location:31198
    Brix; The Brix domain is found in a number of eukaryotic proteins
  5. NM_001320309.2NP_001307238.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Related
    ENST00000460766.5
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  6. NM_001320310.2NP_001307239.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Related
    ENSP00000386716.1, ENST00000409649.5
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  7. NM_001320311.2NP_001307240.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1165
    Brix; The Brix domain is found in a number of eukaryotic proteins
  8. NM_001371725.1NP_001358654.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:86281
    Brix; The Brix domain is found in a number of eukaryotic proteins
  9. NM_001371726.1NP_001358655.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:86269
    Brix; The Brix domain is found in a number of eukaryotic proteins
  10. NM_001371728.1NP_001358657.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:86252
    Brix; The Brix domain is found in a number of eukaryotic proteins
  11. NM_001371730.1NP_001358659.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:1196
    Brix; The Brix domain is found in a number of eukaryotic proteins
  12. NM_001371731.1NP_001358660.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  13. NM_001371732.1NP_001358661.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  14. NM_001371733.1NP_001358662.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  15. NM_001371734.1NP_001358663.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  16. NM_033416.3NP_219484.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

    See identical proteins and their annotated locations for NP_219484.1

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Consensus CDS
    CCDS2160.1
    UniProtKB/Swiss-Prot
    Q3ZTT3, Q96G21
    UniProtKB/TrEMBL
    B8ZZ47
    Related
    ENSP00000259239.3, ENST00000259239.8
    Conserved Domains (1) summary
    smart00879
    Location:86253
    Brix; The Brix domain is found in a number of eukaryotic proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130342897..130347967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    130776821..130781891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)