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mntH Mn(2(+))/Fe(2(+)): H(+) symporter MntH [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946899, updated on 2-May-2024

Summary

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Gene symbol
mntH
Gene description
Mn(2(+))/Fe(2(+)): H(+) symporter MntH
Primary source
ASAP:ABE-0007889
Locus tag
b2392
See related
ECOCYC:G7254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2387; mntA; yfeP
Summary
Fur and OxyR regulons. [More information is available at EcoGene: EG14157]. The MntH protein is a member of the natural resistance-associated macrophage proteins (NRAMP) family of metal ion transporters. [More information is available at EcoCyc: G7254].
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Genomic context

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Sequence:
NC_000913.3 (2511468..2512706, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YfeO Neighboring gene DUF2502 domain-containing protein YpeC Neighboring gene protein YpeD Neighboring gene nucleoside:H(+) symporter NupC Neighboring gene putative IS186/IS421 transposase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ion channel activity of transmembrane segment 6 of Escherichia coli proton-dependent manganese transporter. Nunuková V, et al. Biopolymers, 2010 Aug. PMID 20517953
  2. Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity. Haemig HA, et al. Biochemistry, 2010 Jun 8. PMID 20441230, Free PMC Article
  3. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Courville P, et al. J Biol Chem, 2008 Apr 11. PMID 18227061
  4. Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo. Chaloupka R, et al. Biochemistry, 2005 Jan 18. PMID 15641799
  5. Importance of conserved acidic residues in mntH, the Nramp homolog of Escherichia coli. Haemig HA, et al. J Membr Biol, 2004 Sep 15. PMID 15630547

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthetic peptides corresponding to the sixth transmembrane segment of MntH(Proton-dependent Manganese Transporter) and its two mutations in the functionally important conserved histidine residue were used as a model for structure-function study of MntH.
    Title: Ion channel activity of transmembrane segment 6 of Escherichia coli proton-dependent manganese transporter.
  2. Multiple conserved residues on transmembrane segment 6 of MntH may comprise an important face that is critical for protein
    Title: Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity.
  3. Failure to induce MntH results in a profound growth defect during H2O2 stress, and mutants that cannot import manganese are unable to sequester iron.
    Title: Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli.
  4. Study reveals structural and functional roles for four Nramp-specific transmembrane residues in MntH that may have contributed to the emergence of this family of metal and proton cotransporters.
    Title: Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cadmium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadmium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uniporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cadmium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cadmium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cadmium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cobalt ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in manganese import into cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within manganese ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metal ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mn(2(+))/Fe(2(+)): H(+) symporter MntH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2511468..2512706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416893.1 Mn(2(+))/Fe(2(+)): H(+) symporter MntH [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416893.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A5W5
    Conserved Domains (1) summary
    PRK00701
    Location:1 → 412
    PRK00701; divalent metal cation transporter MntH
Nucleotide Protein
Heading Accession and Version

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Other Literature Sources
Molecular Biology Databases
Research Materials