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PAGE4 PAGE family member 4 [ Homo sapiens (human) ]

Gene ID: 9506, updated on 2-Nov-2024

Summary

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Official Symbol
PAGE4provided by HGNC
Official Full Name
PAGE family member 4provided by HGNC
Primary source
HGNC:HGNC:4108
See related
Ensembl:ENSG00000101951 MIM:300287; AllianceGenome:HGNC:4108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JM27; JM-27; CT16.7; GAGE-9; GAGEC1; PAGE-1; PAGE-4
Summary
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward placenta (RPKM 272.2) See more
Orthologs
all
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Genomic context

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See PAGE4 in Genome Data Viewer
Location:
Xp11.23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (49829260..49834264)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (49145174..49150178)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49593863..49598867)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 1 pseudogene 1 Neighboring gene PAGE family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:49593810-49594310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:49600770-49601270 Neighboring gene Sharpr-MPRA regulatory region 10598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:49639467-49639967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20847 Neighboring gene USP27X divergent transcript Neighboring gene ubiquitin specific peptidase 27 X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress. Li Y, et al. Oxid Med Cell Longev, 2022. PMID 35633887, Free PMC Article
  2. PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers. Iavarone C, et al. Mol Cancer Ther, 2002 Mar. PMID 12489849
  3. Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells. Fu S, et al. J Cell Biochem, 2020 Nov. PMID 32003504
  4. PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway. Lv C, et al. J Exp Clin Cancer Res, 2019 Jan 18. PMID 30658679, Free PMC Article
  5. Prostate-associated gene 4 (PAGE4) protects cells against stress by elevating p21 and suppressing reactive oxygen species production. Zeng Y, et al. Am J Clin Exp Urol, 2013. PMID 25374899, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress.
    Title: The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress.
  2. Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells.
    Title: Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells.
  3. Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
    Title: Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
  4. PAGE4 protects PCa cells from DNA damage and apoptosis under oxidative stress by modulating MAPK signalling pathway. PAGE4 expression may serve as a prognostic biomarker for clinical applications.
    Title: PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.
  5. phosphorylation of PAGE4 leads to conformational shifts
    Title: Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.
  6. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
    Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
  7. Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer.
    Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
  8. Dysregulation of epithelial PAGE4 modulates AR signaling.
    Title: PAGE4 positivity is associated with attenuated AR signaling and predicts patient survival in hormone-naive prostate cancer.
  9. PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function
    Title: The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.
  10. PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens
    Title: PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35184

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P antigen family member 4
Names
P antigen family, member 4 (prostate associated)
g antigen family C member 1
prostate-associated gene protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318877.1 → NP_001305806.1  P antigen family member 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC231644, AI093155, AL548759
    Consensus CDS
    CCDS35274.1
    UniProtKB/Swiss-Prot
    B2R529, D3DX68, O60829, Q6IBI1
    Related
    ENSP00000365311.1, ENST00000376141.5
    Conserved Domains (1) summary
    pfam05831
    Location:14 → 98
    GAGE; GAGE protein

  2. NM_007003.4 → NP_008934.1  P antigen family member 4

    See identical proteins and their annotated locations for NP_008934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC231644, AL548759, BG435968, DA841276
    Consensus CDS
    CCDS35274.1
    UniProtKB/Swiss-Prot
    B2R529, D3DX68, O60829, Q6IBI1
    Related
    ENSP00000218068.6, ENST00000218068.7
    Conserved Domains (1) summary
    pfam05831
    Location:14 → 98
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    49829260..49834264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442678.1 → XP_047298634.1  P antigen family member 4 isoform X1

    UniProtKB/Swiss-Prot
    B2R529, D3DX68, O60829, Q6IBI1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    49145174..49150178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60829.1 GenPept UniProtKB/Swiss-Prot:O60829

Gene LinkOut

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