U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPRASP1 G protein-coupled receptor associated sorting protein 1 [ Homo sapiens (human) ]

Gene ID: 9737, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
GPRASP1provided by HGNC
Official Full Name
G protein-coupled receptor associated sorting protein 1provided by HGNC
Primary source
HGNC:HGNC:24834
See related
Ensembl:ENSG00000198932 MIM:300417; AllianceGenome:HGNC:24834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP; GASP1; GASP-1
Summary
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Expression
Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GPRASP1 in Genome Data Viewer
Location:
Xq22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102651483..102659083)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101096438..101104038)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101906411..101914011)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:101854489-101855260 Neighboring gene armadillo repeat containing X-linked 5 Neighboring gene H3 histone pseudogene 45 Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer. Zhang T, et al. J Oral Pathol Med, 2023 Mar. PMID 36264603
  2. Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs). Abu-Helo A, et al. Pharmacol Ther, 2010 Jun. PMID 20394773
  3. Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. Martini L, et al. FASEB J, 2007 Mar. PMID 17197383
  4. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. Tuszynski GP, et al. Exp Mol Pathol, 2011 Oct. PMID 21791203
  5. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker. Zheng X, et al. Exp Mol Pathol, 2012 Aug. PMID 22483848

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
    Title: GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
  2. Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
    Title: Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
  3. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
    Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
  4. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
    Title: Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.
  5. Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1.
    Title: ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells.
  6. GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas.
    Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker.
  7. GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55
    Title: The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
  8. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.
    Title: Strength training with blood flow restriction diminishes myostatin gene expression.
  9. These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer.
    Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer.
  10. following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1)
    Title: Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Readthrough ARMCX5-GPRASP2

Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

Homology

Clone Names

  • KIAA0443

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor-associated sorting protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021332.1 RefSeqGene

    Range
    5118..12718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001099410.2 → NP_001092880.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001092880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, DA104338
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    O43168, Q5JY77, Q96LA1
    Related
    ENSP00000393691.1, ENST00000415986.5
    Conserved Domains (1) summary
    pfam04826
    Location:1167 → 1390
    Arm_2; Armadillo-like

  2. NM_001099411.2 → NP_001092881.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001092881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, DA094297
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    O43168, Q5JY77, Q96LA1
    Related
    ENSP00000409420.1, ENST00000444152.5
    Conserved Domains (1) summary
    pfam04826
    Location:1167 → 1390
    Arm_2; Armadillo-like

  3. NM_001184727.2 → NP_001171656.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001171656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, BX489726, BX954816
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    O43168, Q5JY77, Q96LA1
    Related
    ENSP00000445683.1, ENST00000537097.2
    Conserved Domains (1) summary
    pfam04826
    Location:1167 → 1390
    Arm_2; Armadillo-like

  4. NM_014710.5 → NP_055525.3  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_055525.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a dominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AW293629, AY044233, BC114552, DA222893
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    O43168, Q5JY77, Q96LA1
    Related
    ENSP00000355146.4, ENST00000361600.9
    Conserved Domains (1) summary
    pfam04826
    Location:1167 → 1390
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102651483..102659083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101096438..101104038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JY77.3 GenPept UniProtKB/Swiss-Prot:Q5JY77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools