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TBC1D5 TBC1 domain family member 5 [ Homo sapiens (human) ]

Gene ID: 9779, updated on 5-Mar-2024

Summary

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Official Symbol
TBC1D5provided by HGNC
Official Full Name
TBC1 domain family member 5provided by HGNC
Primary source
HGNC:HGNC:19166
See related
Ensembl:ENSG00000131374 MIM:615740; AllianceGenome:HGNC:19166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in Golgi apparatus; autophagosome; and endosome membrane. Part of retromer complex. Colocalizes with AP-2 adaptor complex and Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 11.6), brain (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

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See TBC1D5 in Genome Data Viewer
Location:
3p24.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (17157162..17742631, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (17159342..17744665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (17198654..17784123, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipase C like 2 Neighboring gene microRNA 3714 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:17041383-17041908 Neighboring gene Sharpr-MPRA regulatory region 1410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19561 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:17080505-17081704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19562 Neighboring gene PLCL2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19563 Neighboring gene Sharpr-MPRA regulatory region 1226 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_66731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17192997-17193498 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:17194853-17195024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17199910-17200410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17200411-17200911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17211116-17211616 Neighboring gene NANOG hESC enhancer GRCh37_chr3:17217563-17218064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19568 Neighboring gene Sharpr-MPRA regulatory region 10783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19570 Neighboring gene MPRA-validated peak4551 silencer Neighboring gene RBIS pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 9690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:17535720-17536296 Neighboring gene ribosomal protein L31 pseudogene 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:17588257-17589120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19571 Neighboring gene MPRA-validated peak4555 silencer Neighboring gene MPRA-validated peak4556 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17734513-17735014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:17735015-17735514 Neighboring gene tRNA-Cys (anticodon GCA) 25-1 Neighboring gene RNA, U7 small nuclear 10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14125 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:17783809-17784512 Neighboring gene uncharacterized LOC105376975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14128 Neighboring gene uncharacterized LOC124909350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5. Martinez E, et al. J Biol Chem, 2020 May 22. PMID 32303638, Free PMC Article
  2. Structural and mechanistic insights into regulation of the retromer coat by TBC1d5. Jia D, et al. Nat Commun, 2016 Nov 9. PMID 27827364, Free PMC Article
  3. TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. Xie J, et al. Cell Rep, 2020 Jun 9. PMID 32521275, Free PMC Article
  4. TBC1D5 controls the GTPase cycle of Rab7b. Borg Distefano M, et al. J Cell Sci, 2018 Sep 3. PMID 30111580
  5. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy. Jimenez-Orgaz A, et al. EMBO J, 2018 Jan 17. PMID 29158324, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
    Title: TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
  2. The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5.
    Title: The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5.
  3. TBC1D5 is a GAP for Rab7b in the control of endosomal transport to the trans-Golgi.
    Title: TBC1D5 controls the GTPase cycle of Rab7b.
  4. RidL is critical for binding of the L. pneumophila effector to the Vps29 retromer subunit and displacement of the regulator TBC1D5.
    Title: Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
  5. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy.
    Title: Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy.
  6. Data indicate that TBC1 domain family, member 5 protein (TBC1d5) interacts with retromer and the interaction is important for retromer-mediated receptor trafficking.
    Title: Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.
  7. Single nucleotide polymorphisms in TBC1D5 show associations in Schizophrenia and general cognitive function.
    Title: Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.
  8. TBC1D5 and the AP2 complex are important novel regulators of the rerouting of ATG9-containing vesicular carriers toward sites of autophagosome formation.
    Title: TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
    Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2015-10-30)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2015-10-30)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retromer complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Atg1/ULK1 kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
part_of retromer complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TBC1 domain family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134381.2 → NP_001127853.1  TBC1 domain family member 5 isoform a

    See identical proteins and their annotated locations for NP_001127853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 3, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC090644, AK310539, BM976960
    Consensus CDS
    CCDS46770.1
    Related
    ENSP00000402935.2, ENST00000446818.6
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001349073.2 → NP_001336002.1  TBC1 domain family member 5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS46770.1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. NM_001349074.2 → NP_001336003.1  TBC1 domain family member 5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 3, and 5, encodes isoform a.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS46770.1
    Related
    ENSP00000512418.1, ENST00000696125.1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  4. NM_001349075.2 → NP_001336004.1  TBC1 domain family member 5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, and 4, encodes isoform a.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS46770.1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  5. NM_001349076.2 → NP_001336005.1  TBC1 domain family member 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 2, 7, 8, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  6. NM_001349077.2 → NP_001336006.1  TBC1 domain family member 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 2, 6, 8, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Related
    ENSP00000398127.4, ENST00000429383.8
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  7. NM_001349078.2 → NP_001336007.1  TBC1 domain family member 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2, 6, 7, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  8. NM_001349079.2 → NP_001336008.1  TBC1 domain family member 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 2, 6, 7, 8, and 10, encodes isoform b.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  9. NM_001349080.2 → NP_001336009.1  TBC1 domain family member 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 2, 6, 7, 8, and 9, encodes isoform b.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  10. NM_001349081.2 → NP_001336010.1  TBC1 domain family member 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes isoform c.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC140076, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:86 → 388
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  11. NM_001349082.2 → NP_001336011.1  TBC1 domain family member 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform d.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  12. NM_001349083.2 → NP_001336012.1  TBC1 domain family member 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform d.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  13. NM_001349084.2 → NP_001336013.1  TBC1 domain family member 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform d.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  14. NM_001349085.2 → NP_001336014.1  TBC1 domain family member 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform d.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC140076, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  15. NM_001349086.2 → NP_001336015.1  TBC1 domain family member 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform d.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  16. NM_001349087.2 → NP_001336016.1  TBC1 domain family member 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform e.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  17. NM_001349088.2 → NP_001336017.1  TBC1 domain family member 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform e.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  18. NM_001349089.2 → NP_001336018.1  TBC1 domain family member 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform e.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  19. NM_001349090.2 → NP_001336019.1  TBC1 domain family member 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform e.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  20. NM_001349091.2 → NP_001336020.1  TBC1 domain family member 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform e.
    Source sequence(s)
    AC090644, AC090960, AC104451, AC144531
    Conserved Domains (1) summary
    smart00164
    Location:19 → 245
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  21. NM_014744.2 → NP_055559.1  TBC1 domain family member 5 isoform b

    See identical proteins and their annotated locations for NP_055559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 6, 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AC090644, AC104451, BM976960, D86965
    Consensus CDS
    CCDS33714.1
    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1
    Related
    ENSP00000253692.6, ENST00000253692.11
    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    17157162..17742631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449296.1 → XP_047305252.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  2. XM_011534283.4 → XP_011532585.1  TBC1 domain family member 5 isoform X1

    See identical proteins and their annotated locations for XP_011532585.1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. XM_047449314.1 → XP_047305270.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  4. XM_047449291.1 → XP_047305247.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  5. XM_047449286.1 → XP_047305242.1  TBC1 domain family member 5 isoform X1

  6. XM_047449301.1 → XP_047305257.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  7. XM_017007556.2 → XP_016863045.1  TBC1 domain family member 5 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  8. XM_047449303.1 → XP_047305259.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  9. XM_017007555.3 → XP_016863044.1  TBC1 domain family member 5 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  10. XM_047449299.1 → XP_047305255.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  11. XM_047449288.1 → XP_047305244.1  TBC1 domain family member 5 isoform X1

  12. XM_047449297.1 → XP_047305253.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  13. XM_047449285.1 → XP_047305241.1  TBC1 domain family member 5 isoform X1

  14. XM_047449293.1 → XP_047305249.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  15. XM_011534284.3 → XP_011532586.1  TBC1 domain family member 5 isoform X1

    See identical proteins and their annotated locations for XP_011532586.1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  16. XM_047449294.1 → XP_047305250.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  17. XM_047449290.1 → XP_047305246.1  TBC1 domain family member 5 isoform X1

  18. XM_047449308.1 → XP_047305264.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  19. XM_047449317.1 → XP_047305273.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  20. XM_047449287.1 → XP_047305243.1  TBC1 domain family member 5 isoform X1

  21. XM_047449302.1 → XP_047305258.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  22. XM_047449298.1 → XP_047305254.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  23. XM_011534281.2 → XP_011532583.1  TBC1 domain family member 5 isoform X1

    See identical proteins and their annotated locations for XP_011532583.1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  24. XM_047449295.1 → XP_047305251.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  25. XM_047449292.1 → XP_047305248.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  26. XM_017007553.3 → XP_016863042.1  TBC1 domain family member 5 isoform X1

    Conserved Domains (1) summary
    smart00164
    Location:79 → 381
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  27. XM_047449304.1 → XP_047305260.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  28. XM_047449284.1 → XP_047305240.1  TBC1 domain family member 5 isoform X1

  29. XM_047449315.1 → XP_047305271.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  30. XM_047449311.1 → XP_047305267.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  31. XM_047449309.1 → XP_047305265.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  32. XM_047449310.1 → XP_047305266.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  33. XM_047449318.1 → XP_047305274.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  34. XM_047449312.1 → XP_047305268.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  35. XM_047449289.1 → XP_047305245.1  TBC1 domain family member 5 isoform X1

  36. XM_047449319.1 → XP_047305275.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  37. XM_047449306.1 → XP_047305262.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  38. XM_047449316.1 → XP_047305272.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  39. XM_047449305.1 → XP_047305261.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  40. XM_047449313.1 → XP_047305269.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  41. XM_047449300.1 → XP_047305256.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  42. XM_047449322.1 → XP_047305278.1  TBC1 domain family member 5 isoform X3

  43. XM_047449320.1 → XP_047305276.1  TBC1 domain family member 5 isoform X3

  44. XM_047449321.1 → XP_047305277.1  TBC1 domain family member 5 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    17159342..17744665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348556.1 → XP_054204531.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  2. XM_054348542.1 → XP_054204517.1  TBC1 domain family member 5 isoform X1

  3. XM_054348573.1 → XP_054204548.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  4. XM_054348551.1 → XP_054204526.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  5. XM_054348544.1 → XP_054204519.1  TBC1 domain family member 5 isoform X1

  6. XM_054348561.1 → XP_054204536.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  7. XM_054348540.1 → XP_054204515.1  TBC1 domain family member 5 isoform X1

  8. XM_054348563.1 → XP_054204538.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  9. XM_054348547.1 → XP_054204522.1  TBC1 domain family member 5 isoform X1

  10. XM_054348559.1 → XP_054204534.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  11. XM_054348548.1 → XP_054204523.1  TBC1 domain family member 5 isoform X1

  12. XM_054348557.1 → XP_054204532.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  13. XM_054348543.1 → XP_054204518.1  TBC1 domain family member 5 isoform X1

  14. XM_054348553.1 → XP_054204528.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  15. XM_054348539.1 → XP_054204514.1  TBC1 domain family member 5 isoform X1

  16. XM_054348554.1 → XP_054204529.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  17. XM_054348550.1 → XP_054204525.1  TBC1 domain family member 5 isoform X1

  18. XM_054348567.1 → XP_054204542.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  19. XM_054348576.1 → XP_054204551.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  20. XM_054348546.1 → XP_054204521.1  TBC1 domain family member 5 isoform X1

  21. XM_054348562.1 → XP_054204537.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  22. XM_054348558.1 → XP_054204533.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  23. XM_054348545.1 → XP_054204520.1  TBC1 domain family member 5 isoform X1

  24. XM_054348555.1 → XP_054204530.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  25. XM_054348552.1 → XP_054204527.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  26. XM_054348538.1 → XP_054204513.1  TBC1 domain family member 5 isoform X1

  27. XM_054348564.1 → XP_054204539.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  28. XM_054348541.1 → XP_054204516.1  TBC1 domain family member 5 isoform X1

  29. XM_054348574.1 → XP_054204549.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  30. XM_054348570.1 → XP_054204545.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  31. XM_054348568.1 → XP_054204543.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  32. XM_054348569.1 → XP_054204544.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  33. XM_054348577.1 → XP_054204552.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  34. XM_054348571.1 → XP_054204546.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  35. XM_054348549.1 → XP_054204524.1  TBC1 domain family member 5 isoform X1

  36. XM_054348578.1 → XP_054204553.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  37. XM_054348566.1 → XP_054204541.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  38. XM_054348575.1 → XP_054204550.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  39. XM_054348565.1 → XP_054204540.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  40. XM_054348572.1 → XP_054204547.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  41. XM_054348560.1 → XP_054204535.1  TBC1 domain family member 5 isoform X2

    UniProtKB/Swiss-Prot
    A6NP25, C9JP52, Q92609
    UniProtKB/TrEMBL
    B9A6K1

  42. XM_054348581.1 → XP_054204556.1  TBC1 domain family member 5 isoform X3

  43. XM_054348579.1 → XP_054204554.1  TBC1 domain family member 5 isoform X3

  44. XM_054348580.1 → XP_054204555.1  TBC1 domain family member 5 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134380.1: Suppressed sequence

    Description
    NM_001134380.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92609.1 GenPept UniProtKB/Swiss-Prot:Q92609

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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