| miRNA-221-3p and miR-187 were implicated in the acquisition of migration/invasion capacities, sensitivity to the deprivation of growth factors, cell cycle phase regulation, and cell death | miRNA expression profile in multicellular breast cancer spheroids.
Mandujano-Tinoco EA, Garcia-Venzor A, Muñoz-Galindo L, Lizarraga-Sanchez F, Favela-Orozco A, Chavez-Gutierrez E, Krötzsch E, Salgado RM, Melendez-Zajgla J, Maldonado V. | 12/9/2017 |
| Results show that MiR-187 Is significantly decreased in pretreatment esophageal adenocarcinoma (EAC) tumor from non-responder patients suggesting that MIR-187 is involved in treatment resistance of EAC. | Low miR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma.
Lynam-Lennon N, Bibby BA, Mongan AM, Marignol L, Paxton CN, Geiersbach K, Bronner MP, O'Sullivan J, Reynolds J, Maher SG., Free PMC Article | 09/2/2017 |
| miR-187-3p inhibits the migration/metastasis and epithelial mesenchymal transition in hepatocellular carcinoma by targeting S100A4 expression. | miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4.
Dou C, Liu Z, Xu M, Jia Y, Wang Y, Li Q, Yang W, Zheng X, Tu K, Liu Q. | 07/29/2017 |
| High miR187 expression is associated with metastasis of gastric cancer. | MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2.
Li C, Lu S, Shi Y. | 07/15/2017 |
| Results provide a basis for the concept that increased expression of miR-187 in human NSCLC may be significant in the acquisition of an aggressive phenotype. Functional and/or mechanistic studies of miR-187 indicate that miR-187 may play a critical role in controlling non-Smad-mediated epithelial-mesenchymal transition by regulating PTRF expression. | MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer.
Cai Y, Ruan J, Yao X, Zhao L, Wang B. | 07/1/2017 |
| MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer through down-regulation of CYP1B1. | MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1.
Mao M, Wu Z, Chen J. | 06/3/2017 |
| The present study reports that miR-187 was significantly overexpressed in gastric cancer tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis . It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR-187. | MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1.
Ren L, Li F, Di M, Fu Y, Hui Y, Xiao G, Sun Q, Liu Y, Ren D, Du X. | 06/3/2017 |
| these findings reveal that the miR-187-5p-DKK2 pathway regulates Wnt/beta-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL. | miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2.
Lou Y, Liu L, Zhan L, Wang X, Fan H., Free PMC Article | 03/18/2017 |
| The expression of the PTRF protein was significantly weaker than that in the adjacent normal lung tissues using immunohistochemical staining. The findings revealed that miR187 promotes cell growth and invasion by targeting PTRF and miR187 may be a new prognostic factor for nonsmall cell lung cancer | MicroRNA‑187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF.
Peng J, Liu HZ, Zhong J, Deng ZF, Tie CR, Rao Q, Xu W, You T, Li J, Cai CB, Lu Q, Liu W, Zhang Y, Lei ZY. | 03/11/2017 |
| found that miR-187 directly suppressed the expression of SOX4, NT5E and PTK6 | MicroRNA-187, a downstream effector of TGFβ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer.
Zhang F, Luo Y, Shao Z, Xu L, Liu X, Niu Y, Shi J, Sun X, Liu Y, Ding Y, Zhao L. | 07/30/2016 |
| Taken together, our results demonstrated that miR-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6. | MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6.
Sun C, Li S, Yang C, Xi Y, Wang L, Zhang F, Li D. | 07/16/2016 |
| MiR-187 is down regulated in lung tumors. miR-187 expression in tumor cells could perturb cell cycle. | Two lung development-related microRNAs, miR-134 and miR-187, are differentially expressed in lung tumors.
Mirzadeh Azad F, Naeli P, Malakootian M, Baradaran A, Tavallaei M, Ghanei M, Mowla SJ. | 06/28/2016 |
| ALDH1A3 is a target of miR-187 in human prostate cancer. | MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer.
Casanova-Salas I, Masiá E, Armiñán A, Calatrava A, Mancarella C, Rubio-Briones J, Scotlandi K, Vicent MJ, López-Guerrero JA., Free PMC Article | 02/6/2016 |
| miR-187 is a promising biomarker for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers | Identification of miR-187 and miR-182 as biomarkers of early diagnosis and prognosis in patients with prostate cancer treated with radical prostatectomy.
Casanova-Salas I, Rubio-Briones J, Calatrava A, Mancarella C, Masiá E, Casanova J, Fernández-Serra A, Rubio L, Ramírez-Backhaus M, Armiñán A, Domínguez-Escrig J, Martínez F, García-Casado Z, Scotlandi K, Vicent MJ, López-Guerrero JA. | 02/14/2015 |
| indicated that miR187 was related to tumor progression in PTCL-NOS through modulating Ras-mediated ERK/AKT/MYC axis. Although potentially oncogenic, miR187 indicated the sensitivity of T-lymphoma cells to bortezomib | MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma.
Yan ZX, Wu LL, Xue K, Zhang QL, Guo Y, Romero M, Leboeuf C, Janin A, Chen SJ, Wang L, Zhao WL. | 06/21/2014 |
| miR-187 plays a tumor suppressor role in clear cell renal cell carcinoma in a pathway involving B7-H3 | MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3.
Zhao J, Lei T, Xu C, Li H, Ma W, Yang Y, Fan S, Liu Y. | 11/30/2013 |
| miR-187 expression in breast cancer leads to a more aggressive, invasive phenotype and acts as an independent predictor of outcome. | miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro.
Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O'Connor DP. | 06/1/2013 |
| The production of lipopolysaccharides-induced TNF-alpha, IL-6, and IL-12p40 is increased significantly when miR-187 expression is silenced. | IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Rossato M, Curtale G, Tamassia N, Castellucci M, Mori L, Gasperini S, Mariotti B, De Luca M, Mirolo M, Cassatella MA, Locati M, Bazzoni F., Free PMC Article | 01/26/2013 |
| Results indicate that miR-187 directly targeted Disabled homolog-2 (Dab2). | Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.
Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH. | 05/12/2012 |