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    PPP2R3B protein phosphatase 2 regulatory subunit B''beta [ Homo sapiens (human) ]

    Gene ID: 28227, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PPP2R3Bprovided by HGNC
    Official Full Name
    protein phosphatase 2 regulatory subunit B''betaprovided by HGNC
    Primary source
    HGNC:HGNC:13417
    See related
    Ensembl:ENSG00000167393 Ensembl:ENSG00000292327 MIM:300339; AllianceGenome:HGNC:13417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR48; PR70; NYREN8; PPP2R3L; PPP2R3LY
    Summary
    Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
    Expression
    Broad expression in heart (RPKM 9.0), testis (RPKM 5.0) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    X;Y
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (333933..386907, complement)
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (333933..386907, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (164977..218172, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (168543..224805, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (294668..347642, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (244668..297642, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:323668-324173 and GRCh37_chrY:273658-274173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:274174-274688 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:333708-333890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:335885-336775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:357819-358704 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:389565-389736 Neighboring gene uncharacterized LOC102724521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:396687-397186 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chrX:406609-407442 and GRCh37_chrY:356916-357447 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:461079-461645 Neighboring gene CNE-3 enhancer upstream of SHOX Neighboring gene fatty acid binding protein 5 pseudogene 13

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene GTP binding protein 6 (putative) Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:323668-324173 and GRCh37_chrY:273658-274173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:274174-274688 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:333708-333890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:335885-336775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:357819-358704 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:389565-389736 Neighboring gene uncharacterized LOC102724521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:396687-397186 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chrX:406609-407442 and GRCh37_chrY:356916-357447 Neighboring gene CNE-5 enhancer upstream of SHOX Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:461079-461645 Neighboring gene CNE-3 enhancer upstream of SHOX Neighboring gene fatty acid binding protein 5 pseudogene 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A. Dovega R, et al. PLoS One, 2014. PMID 25007185, Free PMC Article
    2. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. Stevens I, et al. Eur J Biochem, 2003 Jan. PMID 12605688
    3. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. Schiebel K, et al. Cytogenet Cell Genet, 2000. PMID 11173861
    4. Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype. Polubothu S, et al. Genet Med, 2021 Sep. PMID 34145395, Free PMC Article
    5. The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene. van Kempen LC, et al. Sci Transl Med, 2016 Dec 14. PMID 27974665

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ60425

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
    Names
    NY-REN-8 antigen
    protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
    protein phosphatase 2, regulatory subunit B'', beta
    serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013257.1 RefSeqGene

      Range
      4986..57960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013239.5 → NP_037371.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

      See identical proteins and their annotated locations for NP_037371.2

      Status: REVIEWED

      Source sequence(s)
      AL954664, BK000521, BM666129, BM715684, DA061573
      Consensus CDS
      CCDS14104.1
      UniProtKB/Swiss-Prot
      Q6P4G9, Q7RTT1, Q96H01, Q9Y5P8
      UniProtKB/TrEMBL
      A0A0G2JN52, A0A0G2JNR6
      Related
      ENSP00000375080.3, ENSP00000518592.1, ENST00000390665.9, ENST00000711115.1
      Conserved Domains (1) summary
      pfam13499
      Location:319 → 417
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      333933..386907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442006.1 → XP_047297962.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

    2. XM_047442001.1 → XP_047297957.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    3. XM_047442004.1 → XP_047297960.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    4. XM_047442005.1 → XP_047297961.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    5. XM_047442002.1 → XP_047297958.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    6. XM_047442003.1 → XP_047297959.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    7. XM_011546177.4 → XP_011544479.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011544479.1

      UniProtKB/TrEMBL
      A0A0G2JN52, A0A0G2JNR6
      Conserved Domains (1) summary
      pfam13499
      Location:319 → 417
      EF-hand_7; EF-hand domain pair

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      333933..386907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442728.1 → XP_047298684.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

    2. XM_047442723.1 → XP_047298679.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    3. XM_047442726.1 → XP_047298682.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    4. XM_047442727.1 → XP_047298683.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    5. XM_047442724.1 → XP_047298680.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    6. XM_047442725.1 → XP_047298681.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    7. XM_011545630.4 → XP_011543932.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011543932.1

      UniProtKB/TrEMBL
      A0A0G2JN52, A0A0G2JNR6
      Conserved Domains (1) summary
      pfam13499
      Location:319 → 417
      EF-hand_7; EF-hand domain pair

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187634.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      17129..70303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442890.1 → XP_047298846.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187667.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      6694..59443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442957.1 → XP_047298913.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X6

    2. XM_047442953.1 → XP_047298909.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    3. XM_047442959.1 → XP_047298915.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    4. XM_047442960.1 → XP_047298916.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

    5. XM_047442954.1 → XP_047298910.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    6. XM_047442958.1 → XP_047298914.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    7. XM_047442956.1 → XP_047298912.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      164977..218172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326861.1 → XP_054182836.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X7

    2. XM_054326865.1 → XP_054182840.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X5

    3. XM_054326858.1 → XP_054182833.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    4. XM_054326863.1 → XP_054182838.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    5. XM_054326864.1 → XP_054182839.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    6. XM_054326859.1 → XP_054182834.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X4

    7. XM_054326862.1 → XP_054182837.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    8. XM_054326860.1 → XP_054182835.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    9. XM_054326866.1 → XP_054182841.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      168543..224805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328277.1 → XP_054184252.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X10

    2. XM_054328271.1 → XP_054184246.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1

    3. XM_054328275.1 → XP_054184250.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    4. XM_054328276.1 → XP_054184251.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    5. XM_054328272.1 → XP_054184247.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X9

    6. XM_054328274.1 → XP_054184249.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X3

    7. XM_054328273.1 → XP_054184248.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199326.1: Suppressed sequence

      Description
      NM_199326.1: This RefSeq was permanently suppressed because the CDS was partial, and the transcript retains intronic sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5P8.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P8

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