ZBTB16 zinc finger and BTB domain containing 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZBTB16provided by HGNC
Official Full Name: zinc finger and BTB domain containing 16provided by HGNC
Primary source: HGNC:HGNC:12930
See related: Ensembl:ENSG00000109906 MIM:176797; AllianceGenome:HGNC:12930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLZF; ZNF145
Summary: This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 27.9), ovary (RPKM 22.2) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (114059711..114256770)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (114070066..114267135)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (113930433..114127492)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells.
Title: Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells.
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.
Title: Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARalpha.
Title: Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα.
The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRalpha1) in the Cryopreservation of Spermatogonia Stem Cells.
Title: The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells.
Bioinformatics Analysis of ZBTB16 as a Prognostic Marker for Ewing's Sarcoma.
Title: Bioinformatics Analysis of ZBTB16 as a Prognostic Marker for Ewing's Sarcoma.
Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
Title: Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia.
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Title: PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
Title: Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27.
Title: BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27.
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.
Title: Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons.

Submit: New GeneRIF Correction See all GeneRIFs (104)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of zinc finger and BTB domain containing 16 (ZBTB16) in Vif-expression T cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2076 (e-PCR)
- UniSTS:150034

NoName (e-PCR)
- UniSTS:99119

A008C32 (e-PCR)
- UniSTS:8275

D11S4022 (e-PCR)
- UniSTS:70488

D11S1104 (e-PCR)
- UniSTS:6488

SHGC-33207 (e-PCR)
- UniSTS:48495

D11S1792 (e-PCR), detects polymorphism
- UniSTS:25463

D11S3462 (e-PCR)
- UniSTS:152703

ZNF145 (e-PCR)
- UniSTS:36228

NoName (e-PCR)
- UniSTS:99223

RH16530 (e-PCR)
- UniSTS:73373

SHGC-80797 (e-PCR)
- UniSTS:102320

GDB:335751 (e-PCR)
- UniSTS:156601

D11S3293 (e-PCR)
- UniSTS:152535

fj34c06.x1 (e-PCR)
- UniSTS:199150

D11S1191 (e-PCR)
- UniSTS:2046

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 2 angiotensin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	IEA Inferred from Electronic Annotation more info
involved_in forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in male germ-line stem cell asymmetric division	IEA Inferred from Electronic Annotation more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in myeloid cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myeloid cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification involved in bone maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NK T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 16

Names: promyelocytic leukaemia zinc finger; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); zinc finger protein PLZF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012140.2 RefSeqGene

Range

5136..202190

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018011.3 → NP_001018011.1 zinc finger and BTB domain-containing protein 16 isoform 1

See identical proteins and their annotated locations for NP_001018011.1

Status: REVIEWED

Source sequence(s)

AP002518, BC026902

Consensus CDS

CCDS8367.1

UniProtKB/Swiss-Prot

Q05516, Q8TAL4

UniProtKB/TrEMBL

A0A024R3C6

Related

ENSP00000376721.2, ENST00000392996.2

Conserved Domains (4) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

cl28033
Location:177 → 327

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_001354750.2 → NP_001341679.1 zinc finger and BTB domain-containing protein 16 isoform 1

Status: REVIEWED

Source sequence(s)

AP000908, AP002518, AP002755

Consensus CDS

CCDS8367.1

UniProtKB/Swiss-Prot

Q05516, Q8TAL4

UniProtKB/TrEMBL

A0A024R3C6

Related

ENSP00000507788.1, ENST00000684295.1

Conserved Domains (4) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

cl28033
Location:177 → 327

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_001354751.2 → NP_001341680.1 zinc finger and BTB domain-containing protein 16 isoform 1

Status: REVIEWED

Source sequence(s)

AP000908, AP002518, AP002755

Consensus CDS

CCDS8367.1

UniProtKB/Swiss-Prot

Q05516, Q8TAL4

UniProtKB/TrEMBL

A0A024R3C6

Related

ENSP00000508351.1, ENST00000683318.1

Conserved Domains (4) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

cl28033
Location:177 → 327

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_001354752.1 → NP_001341681.1 zinc finger and BTB domain-containing protein 16 isoform 2

Status: REVIEWED

Source sequence(s)

AP000908, AP002518, KU178401

Consensus CDS

CCDS91597.1

UniProtKB/TrEMBL

A0A0S2Z4J5

Related

ENSP00000507219.1, ENST00000682810.1

Conserved Domains (4) summary

COG5048
Location:434 → 593

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:491 → 511

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

pfam09606
Location:167 → 327

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
NM_006006.6 → NP_005997.2 zinc finger and BTB domain-containing protein 16 isoform 1

See identical proteins and their annotated locations for NP_005997.2

Status: REVIEWED

Source sequence(s)

AP002518, BC029812, BM969145, BX648973

Consensus CDS

CCDS8367.1

UniProtKB/Swiss-Prot

Q05516, Q8TAL4

UniProtKB/TrEMBL

A0A024R3C6

Related

ENSP00000338157.4, ENST00000335953.9

Conserved Domains (4) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 125

BTB; BTB/POZ domain

cl28033
Location:177 → 327

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

114059711..114256770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005271658.6 → XP_005271715.1 zinc finger and BTB domain-containing protein 16 isoform X1

UniProtKB/TrEMBL

Q71UL7

Conserved Domains (4) summary

smart00225
Location:35 → 106

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:25 → 106

BTB; BTB/POZ domain

pfam13912
Location:460 → 483

zf-C2H2_6; C2H2-type zinc finger
XM_047427563.1 → XP_047283519.1 zinc finger and BTB domain-containing protein 16 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

114070066..114267135

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054369889.1 → XP_054225864.1 zinc finger and BTB domain-containing protein 16 isoform X1
XM_054369890.1 → XP_054225865.1 zinc finger and BTB domain-containing protein 16 isoform X2
XM_054369888.1 → XP_054225863.1 zinc finger and BTB domain-containing protein 16 isoform X3

UniProtKB/Swiss-Prot

Q05516, Q8TAL4

UniProtKB/TrEMBL

A0A024R3C6