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    PAK5 p21 (RAC1) activated kinase 5 [ Homo sapiens (human) ]

    Gene ID: 57144, updated on 14-Nov-2024

    Summary

    Official Symbol
    PAK5provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:15916
    See related
    Ensembl:ENSG00000101349 MIM:608038; AllianceGenome:HGNC:15916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAK7
    Summary
    The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See PAK5 in Genome Data Viewer
    Location:
    20p12.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (9537370..9839076, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (9580273..9881978, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (9518017..9819724, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9055836-9056336 Neighboring gene Sharpr-MPRA regulatory region 7247 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9160877-9161492 Neighboring gene phospholipase C beta 4 Neighboring gene MPRA-validated peak4143 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:9496172-9496756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9499300-9500006 Neighboring gene LAMP5 antisense RNA 1 Neighboring gene uncharacterized LOC105372523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:9553223-9553723 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:9557290-9557799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17538 Neighboring gene uncharacterized LOC101929348 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17540 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:9958069-9959268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12670 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:10028171-10028363 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:10029614-10030813 Neighboring gene SNAP25 antisense RNA 1 Neighboring gene PPARG activating RBM14 associated lncRNA 1 Neighboring gene ankyrin repeat and EF-hand domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1264, MGC26232

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Process Evidence Code Pubs
    involved_in apoptotic process PubMed 
    involved_in cell migration PubMed 
    involved_in cell population proliferation PubMed 
    involved_in cellular response to starvation  
    involved_in chromatin remodeling  
    involved_in cytoskeleton organization PubMed 
    involved_in intracellular signal transduction  
    involved_in learning  
    involved_in locomotory behavior  
    involved_in memory  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in regulation of MAPK cascade  
    involved_in regulation of cell growth PubMed 
    involved_in signal transduction PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in plasma membrane  
    located_in synapse  

    General protein information

    Preferred Names
    serine/threonine-protein kinase PAK 5
    Names
    PAK-5
    PAK-7
    p21 (RAC1) activated kinase 7
    p21 protein (Cdc42/Rac)-activated kinase 7
    p21(CDKN1A)-activated kinase 7
    p21-activated kinase 5
    p21-activated kinase 7
    p21CDKN1A-activated kinase 7
    protein kinase PAK5
    serine/threonine-protein kinase PAK 7
    serine/threonine-protein kinase PAK7
    NP_065074.1
    NP_817127.1
    XP_016883449.1
    XP_016883450.1
    XP_016883451.1
    XP_016883453.1
    XP_016883454.1
    XP_054179701.1
    XP_054179702.1
    XP_054179703.1
    XP_054179704.1
    XP_054179705.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020341.5NP_065074.1  serine/threonine-protein kinase PAK 5

      See identical proteins and their annotated locations for NP_065074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.
      Source sequence(s)
      AB033090, AB040812, AK315820, AL031652, AL034427
      Consensus CDS
      CCDS13107.1
      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Related
      ENSP00000367686.3, ENST00000378429.3
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    2. NM_177990.4NP_817127.1  serine/threonine-protein kinase PAK 5

      See identical proteins and their annotated locations for NP_817127.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal 5' UTR exon, as compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AB040812, AK307926, AK315820, AL031652, AL034427
      Consensus CDS
      CCDS13107.1
      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Related
      ENSP00000322957.5, ENST00000353224.10
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      9537370..9839076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027960.2XP_016883449.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    2. XM_017027961.2XP_016883450.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    3. XM_017027962.2XP_016883451.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    4. XM_017027964.2XP_016883453.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    5. XM_017027965.2XP_016883454.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
      UniProtKB/TrEMBL
      B0AZM9
      Conserved Domains (2) summary
      cd06658
      Location:426717
      STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5
      cd01093
      Location:955
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      9580273..9881978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323727.1XP_054179702.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
    2. XM_054323728.1XP_054179703.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
    3. XM_054323726.1XP_054179701.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
    4. XM_054323729.1XP_054179704.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
    5. XM_054323730.1XP_054179705.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K5T6, D3DW14, Q5W115, Q8TB93, Q9BX09, Q9P286, Q9ULF6
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