EEF1G eukaryotic translation elongation factor 1 gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: EEF1Gprovided by HGNC
Official Full Name: eukaryotic translation elongation factor 1 gammaprovided by HGNC
Primary source: HGNC:HGNC:3213
See related: Ensembl:ENSG00000254772 MIM:130593; AllianceGenome:HGNC:3213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EF1G; GIG35
Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in ovary (RPKM 1189.4), lymph node (RPKM 694.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (62559596..62573891, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (62549046..62563344, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (62327068..62341363, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study describes a novel EEF1G-ALK gene fusion in 2 pediatric patients with anaplastic large cell lymphoma that is associated with a cytoplasmic-restricted localization of the ALK fusion protein
Title: Novel ALK fusion in anaplastic large cell lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex.
Results show that eEF1Bgamma binds not only Che-1 and p53 transcripts but also their promoters. Its depletion significantly decreases p53 protein accumulation and slightly impacts on Che-1 accumulation in the mitochondria. These data support the notion that eEF1Bgamma, besides its canonical role in translation, is an RNA-binding protein and a key player in cellular stress responses.
Title: eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.
eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA
Title: The eEF1γ subunit contacts RNA polymerase II and binds vimentin promoter region.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1	PubMed
	nef	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
integrase	gag-pol	HIV-1 IN co-immunoprecipitates with eEF1G through an interaction with the viral RTCs	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 1 gamma (EEF1G) at amino acid residues 20-21 by the HIV-1 protease	PubMed
reverse transcriptase p51 subunit	gag-pol	HIV-1 RT p51 subunit co-immunoprecipitates with eEF1A through an interaction with the viral RTCs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:493314 (e-PCR)
- UniSTS:493314

DXS6993E (e-PCR)
- UniSTS:45839

RH66302 (e-PCR)
- UniSTS:3624

GDB:451619 (e-PCR)
- UniSTS:157328

SHGC-57995 (e-PCR)
- UniSTS:31892

ksks40 (e-PCR)
- UniSTS:514453

D7S2869 (e-PCR)
- UniSTS:27313

RH15603 (e-PCR)
- UniSTS:84660

SHGC-2363 (e-PCR)
- UniSTS:88521

MARC_5385-5386:991939571:3 (e-PCR)
- UniSTS:231150

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
colocalizes_with endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongation factor 1-gamma

Names: EF-1-gamma; PRO1608; eEF-1B gamma; pancreatic tumor-related protein; translation elongation factor eEF-1 gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404.5 → NP_001395.1 elongation factor 1-gamma

See identical proteins and their annotated locations for NP_001395.1

Status: REVIEWED

Source sequence(s)

AP001363, BC028179, BQ947806, X63526

Consensus CDS

CCDS44626.1

UniProtKB/Swiss-Prot

B4DTG2, P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196

UniProtKB/TrEMBL

Q53YD7

Related

ENSP00000331901.4, ENST00000329251.5

Conserved Domains (4) summary

cd03181
Location:91 → 213

GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins

PRK09510
Location:212 → 278

tolA; cell envelope integrity inner membrane protein TolA; Provisional

cd03044
Location:4 → 82

GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...

pfam00647
Location:277 → 381

EF1G; Elongation factor 1 gamma, conserved domain