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    IQGAP3 IQ motif containing GTPase activating protein 3 [ Homo sapiens (human) ]

    Gene ID: 128239, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IQGAP3provided by HGNC
    Official Full Name
    IQ motif containing GTPase activating protein 3provided by HGNC
    Primary source
    HGNC:HGNC:20669
    See related
    Ensembl:ENSG00000183856 AllianceGenome:HGNC:20669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IQGAP3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156525405..156572565, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155663992..155708965, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156495197..156542357, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIR9-1 host gene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156390239-156390770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156391951-156392452 Neighboring gene microRNA 9-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:156409392-156409986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156409987-156410580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156418512-156419012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156426495-156427452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156427509-156428010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156428011-156428510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156431759-156432710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156561722-156562568 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene NAD(P)HX epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. Oue N, et al. Pathobiology, 2018. PMID 29131081
    2. IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation. Hu G, et al. Med Sci Monit, 2019 Oct 12. PMID 31605603, Free PMC Article
    3. Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. Jinawath N, et al. Biomolecules, 2020 Aug 17. PMID 32824461, Free PMC Article
    4. IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. Yang Y, et al. PLoS One, 2014. PMID 24849319, Free PMC Article
    5. High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients. Wu J, et al. Int J Biol Markers, 2019 Dec. PMID 31544570

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Infiltrative Vessel Co-optive Growth Pattern Induced by IQGAP3 Overexpression Promotes Microvascular Invasion in Hepatocellular Carcinoma.
      Title: Infiltrative Vessel Co-optive Growth Pattern Induced by IQGAP3 Overexpression Promotes Microvascular Invasion in Hepatocellular Carcinoma.
    2. IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases.
      Title: IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases.
    3. Identification and validation of non-coding RNA-mediated high expression of IQGAP3 in poor prognosis of lung adenocarcinoma.
      Title: Identification and validation of non-coding RNA-mediated high expression of IQGAP3 in poor prognosis of lung adenocarcinoma.
    4. IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms.
      Title: IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms.
    5. IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.
      Title: IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.
    6. CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
      Title: CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
    7. Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer.
      Title: Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer.
    8. IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.
      Title: IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.
    9. Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
      Title: Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
    10. IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
      Title: IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1947, MGC10170, MGC10831

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin VI light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178229.5 → NP_839943.3  ras GTPase-activating-like protein IQGAP3

      Status: VALIDATED

      Source sequence(s)
      AL365181
      Consensus CDS
      CCDS1144.1
      UniProtKB/Swiss-Prot
      Q5T3H8, Q86VI3
      UniProtKB/TrEMBL
      A2RRC9
      Related
      ENSP00000354451.2, ENST00000361170.7
      Conserved Domains (3) summary
      cd12207
      Location:987 → 1336
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      cl27227
      Location:861 → 1631
      RasGAP_C; RasGAP C-terminus
      cl27381
      Location:734 → 957
      Myosin_head; Myosin head (motor domain)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156525405..156572565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445996.1 → XP_047301952.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    2. XM_047445990.1 → XP_047301946.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_011509198.4 → XP_011507500.1  ras GTPase-activating-like protein IQGAP3 isoform X1

      UniProtKB/TrEMBL
      A2RRC9
      Conserved Domains (5) summary
      smart00015
      Location:768 → 785
      IQ; Calmodulin-binding motif
      cd12207
      Location:992 → 1341
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:981 → 1334
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:40 → 152
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam03836
      Location:1453 → 1559
      RasGAP_C; RasGAP C-terminus

    4. XM_047446003.1 → XP_047301959.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    5. XM_011509201.2 → XP_011507503.1  ras GTPase-activating-like protein IQGAP3 isoform X6

      Conserved Domains (4) summary
      smart00015
      Location:267 → 284
      IQ; Calmodulin-binding motif
      cd12207
      Location:491 → 840
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:480 → 833
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:952 → 1058
      RasGAP_C; RasGAP C-terminus

    6. XM_011509200.3 → XP_011507502.1  ras GTPase-activating-like protein IQGAP3 isoform X5

      Conserved Domains (4) summary
      smart00015
      Location:321 → 338
      IQ; Calmodulin-binding motif
      cd12207
      Location:545 → 894
      RasGAP_IQGAP3; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
      smart00323
      Location:534 → 887
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:1006 → 1112
      RasGAP_C; RasGAP C-terminus

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      83962..131166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332827.1 → XP_054188802.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    2. XM_054332828.1 → XP_054188803.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_054332829.1 → XP_054188804.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    4. XM_054332830.1 → XP_054188805.1  ras GTPase-activating-like protein IQGAP3 isoform X4

    5. XM_054332832.1 → XP_054188807.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    6. XM_054332831.1 → XP_054188806.1  ras GTPase-activating-like protein IQGAP3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155663992..155708965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334424.1 → XP_054190399.1  ras GTPase-activating-like protein IQGAP3 isoform X1

    2. XM_054334425.1 → XP_054190400.1  ras GTPase-activating-like protein IQGAP3 isoform X2

    3. XM_054334422.1 → XP_054190397.1  ras GTPase-activating-like protein IQGAP3 isoform X8

    4. XM_054334421.1 → XP_054190396.1  ras GTPase-activating-like protein IQGAP3 isoform X7

    5. XM_054334426.1 → XP_054190401.1  ras GTPase-activating-like protein IQGAP3 isoform X3

    6. XM_054334423.1 → XP_054190398.1  ras GTPase-activating-like protein IQGAP3 isoform X9

    7. XM_054334427.1 → XP_054190402.1  ras GTPase-activating-like protein IQGAP3 isoform X10

    8. XM_054334429.1 → XP_054190404.1  ras GTPase-activating-like protein IQGAP3 isoform X6

    9. XM_054334428.1 → XP_054190403.1  ras GTPase-activating-like protein IQGAP3 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VI3.2 GenPept UniProtKB/Swiss-Prot:Q86VI3

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