IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGF2BP1provided by HGNC
Official Full Name: insulin like growth factor 2 mRNA binding protein 1provided by HGNC
Primary source: HGNC:HGNC:28866
See related: Ensembl:ENSG00000159217 MIM:608288; AllianceGenome:HGNC:28866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
Summary: This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Annotation information: Note: ZBP1 (GeneID: 81030) and IGF2BP1 (GeneID:10642) share the ZBP1 symbol/alias in common. ZBP1 is a widely used alternative name for insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), which can be confused with the official symbol for ZBP1, Z-DNA binding protein 1 (ZBP1). [09 Aug 2021]
Expression: Biased expression in testis (RPKM 3.6), placenta (RPKM 2.9) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.32

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (48996558..49056145)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (49859908..49919501)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (47074747..47133507)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Title: RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1.
Title: METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1.
N[6]-Methyladenosine (m[6]A) Reader IGF2BP1 Accelerates Gastric Cancer Development and Immune Escape by Targeting PD-L1.
Title: N(6)-Methyladenosine (m(6)A) Reader IGF2BP1 Accelerates Gastric Cancer Development and Immune Escape by Targeting PD-L1.
METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
Title: METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
Title: ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.
Title: The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in hypermitotic meningiomas.
A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
Title: A Mettl16/m(6)A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation.
Title: m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation.
m 6 A reader IGF2BP1 reduces the sensitivity of nasopharyngeal carcinoma cells to Taxol by upregulation of AKT2.
Title: m 6 A reader IGF2BP1 reduces the sensitivity of nasopharyngeal carcinoma cells to Taxol by upregulation of AKT2.
Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.
Title: Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.

Submit: New GeneRIF Correction See all GeneRIFs (163)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	gag	Expression of IMP1 protein decreases HIV-1 infectivity, inhibits viral RNA packaging, and impedes the assembly and processing of Gag on cellular membrane	PubMed
	gag	Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1	PubMed
	gag	IMP1 co-localizes with HIV-1 Gag in cells and is packaged into virus particles via its interaction with HIV-1 Gag	PubMed
Rev	rev	IMP1 interacts with HIV-1 Rev and has the ability of relocating Rev from the nucleus to the cytoplasm	PubMed
nucleocapsid	gag	Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-154117 (e-PCR)
- UniSTS:183069

RH35899 (e-PCR)
- UniSTS:79433

SGC34830 (e-PCR)
- UniSTS:43919

SHGC-148228 (e-PCR)
- UniSTS:172959

RH91858 (e-PCR)
- UniSTS:85418

RH16179 (e-PCR)
- UniSTS:11235

WI-4369 (e-PCR)
- UniSTS:78333

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite arborization	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in pallium cell proliferation in forebrain	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production	IC Inferred by Curator more info	PubMed
involved_in regulation of mRNA stability involved in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CRD-mediated mRNA stability complex	IDA Inferred from Direct Assay more info	PubMed
part_of CRD-mediated mRNA stability complex	IPI Inferred from Physical Interaction more info	PubMed
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 1

Names: IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; VICKZ family member 1; ZBP-1; coding region determinant-binding protein; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; zipcode-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030585.1 RefSeqGene

Range

4974..63734

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001160423.2 → NP_001153895.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001153895.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AC091133, AC105030, DA758608, DQ227344

Consensus CDS

CCDS54138.1

UniProtKB/Swiss-Prot

Q9NZI8

Related

ENSP00000389135.2, ENST00000431824.2

Conserved Domains (5) summary

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd22493
Location:135 → 230

KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22496
Location:265 → 340

KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22499
Location:348 → 423

KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cl17169
Location:81 → 135

RRM_SF; RNA recognition motif (RRM) superfamily
NM_006546.4 → NP_006537.3 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_006537.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC091133, AC105030, AF198254, AK074915, BP238821

Consensus CDS

CCDS11543.1

UniProtKB/Swiss-Prot

C9JT33, Q9NZI8

Related

ENSP00000290341.3, ENST00000290341.8

Conserved Domains (6) summary

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd12628
Location:81 → 156

RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd22490
Location:197 → 272

KH-I_IGF2BP1_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22493
Location:273 → 369

KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22496
Location:404 → 479

KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22499
Location:487 → 562

KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

48996558..49056145

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435139.1 → XP_047291095.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

C9JT33, Q9NZI8
XM_011524201.3 → XP_011522503.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X2

See identical proteins and their annotated locations for XP_011522503.1

Conserved Domains (6) summary

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd12628
Location:81 → 156

RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd22490
Location:197 → 272

KH-I_IGF2BP1_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22493
Location:273 → 369

KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22496
Location:403 → 478

KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

cd22499
Location:486 → 561

KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
XM_017024022.2 → XP_016879511.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X3

Conserved Domains (3) summary

smart00322
Location:275 → 347

KH; K homology RNA-binding domain

smart00360
Location:82 → 151

RRM; RNA recognition motif

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
XM_047435140.1 → XP_047291096.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X4
XM_047435143.1 → XP_047291099.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X8

UniProtKB/TrEMBL

D3DTW3
XM_005256955.4 → XP_005257012.2 insulin-like growth factor 2 mRNA-binding protein 1 isoform X5

Conserved Domains (3) summary

COG0724
Location:57 → 146

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00105
Location:267 → 332

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12628
Location:69 → 144

RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
XM_047435141.1 → XP_047291097.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X6
XM_047435142.1 → XP_047291098.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X7

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

49859908..49919501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314727.1 → XP_054170702.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

C9JT33, Q9NZI8
XM_054314729.1 → XP_054170704.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X2
XM_054314728.1 → XP_054170703.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X2
XM_054314730.1 → XP_054170705.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X3
XM_054314731.1 → XP_054170706.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X4
XM_054314732.1 → XP_054170707.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X5
XM_054314733.1 → XP_054170708.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X5
XM_054314734.1 → XP_054170709.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X6
XM_054314736.1 → XP_054170711.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X7
XM_054314737.1 → XP_054170712.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X8

UniProtKB/TrEMBL

D3DTW3
XM_054314735.1 → XP_054170710.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform X6