Envelope surface glycoprotein gp120
|
env
|
HIV-1 Env gp120 upregulates MAPK8 (JNK) in SVGA cells, human fetal astrocytes, and the prefrontal cortex of gp120 transgenic mice |
PubMed
|
|
env
|
HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells |
PubMed
|
|
env
|
Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK |
PubMed
|
|
env
|
NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response |
PubMed
|
|
env
|
HIV-1 Env-pseudotyped virus-infected MDM cells induce cellular apoptosis through reactive oxygen species (ROS) generation and JNK phosphorylation |
PubMed
|
|
env
|
CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK |
PubMed
|
|
env
|
The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 |
PubMed
|
|
env
|
HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells |
PubMed
|
|
env
|
Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB |
PubMed
|
|
env
|
HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes |
PubMed
|
Envelope surface glycoprotein gp160, precursor
|
env
|
The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells |
PubMed
|
|
env
|
Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin |
PubMed
|
Nef
|
nef
|
HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 |
PubMed
|
|
nef
|
HIV-1 Nef inhibits ASK1-induced phosphorylation of p54/p46 JNK in cells. Nef mutant (152DEVGEANN/AAAAAAAA159) abolishes its inhibitory activity |
PubMed
|
|
nef
|
HIV-1 Nef activates c-jun nuclear kinase (JNK) in human glial cells and the resulting activation promotes cell proliferation |
PubMed
|
|
nef
|
The interaction between HIV-1 Nef and Vav leads to the activation of c-Jun N-terminal kinase (JNK) |
PubMed
|
|
nef
|
Using genetic and immunohistochemical studies in Drosophila transgenic lines, wild-type HIV-1 Nef demonstrates induction of JNK activation and apoptotic activities |
PubMed
|
Tat
|
tat
|
HIV-1 Tat induces phosphorylation of MAPK8 (JNK) in CRT-MG human astroglioma cells |
PubMed
|
|
tat
|
HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes |
PubMed
|
|
tat
|
Pretreatment of microglia with HIV-1 Tat followed by treatment with CX3CL1 results in inhibition of CX3CL1-mediated activation of ERK1/2 and JNK MAPKs compared to cells not treated with Tat |
PubMed
|
|
tat
|
HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes |
PubMed
|
|
tat
|
Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression |
PubMed
|
|
tat
|
Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP |
PubMed
|
|
tat
|
HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck |
PubMed
|
|
tat
|
Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells |
PubMed
|
|
tat
|
Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 |
PubMed
|
|
tat
|
HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation |
PubMed
|
|
tat
|
Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat |
PubMed
|
|
tat
|
HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) |
PubMed
|
|
tat
|
Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways |
PubMed
|
|
tat
|
HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha |
PubMed
|
|
tat
|
Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT |
PubMed
|
|
tat
|
Activation of JNK by HIV-1 Tat is mediated by TRAF4 |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr-mediated regulation of IL6 involves MAPK8 (JnK-MAPK8) in astrocytes |
PubMed
|
|
vpr
|
Vpr-mediated CXCL8 (IL8) secretion from astrocytes involves MAPK8 (Jnk-MAPK) |
PubMed
|
|
vpr
|
Vpr-mediated CXCL8 (IL8) mRNA expression involves MAPK8 (Jnk-MAPK) in astrocytes |
PubMed
|
|
vpr
|
Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. |
PubMed
|
integrase
|
gag-pol
|
Cellular JNK1 phosphorylates HIV-1 IN on Ser57, leading to efficient HIV-1 infection and integration in primary human T lymphocytes |
PubMed
|