U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DHX15 DEAH-box helicase 15 [ Homo sapiens (human) ]

    Gene ID: 1665, updated on 28-Oct-2024

    Summary

    Official Symbol
    DHX15provided by HGNC
    Official Full Name
    DEAH-box helicase 15provided by HGNC
    Primary source
    HGNC:HGNC:2738
    See related
    Ensembl:ENSG00000109606 MIM:603403; AllianceGenome:HGNC:2738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBP1; DDX15; PRP43; PRPF43; hPrp43; PrPp43p
    Summary
    The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 42.0), lymph node (RPKM 36.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DHX15 in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (24527475..24584554, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (24509189..24566252, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (24529098..24586177, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24501891-24502492 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24502493-24503092 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24507891-24508628 Neighboring gene microRNA 573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:24554813-24555381 Neighboring gene RNA, 7SL, cytoplasmic 16, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21369 Neighboring gene uncharacterized LOC124900682 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:24599261-24600460 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:24659537-24660178 Neighboring gene ATP synthase membrane subunit g pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DEAH (Asp-Glu-Ala-His) box polypeptide 15 (DHX15) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify DEAH (Asp-Glu-Ala-His) box polypeptide 15 (DHX15), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify DEAH (Asp-Glu-Ala-His) box polypeptide 15 (DHX15), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify DEAH (Asp-Glu-Ala-His) box polypeptide 15 (DHX15), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify DEAH (Asp-Glu-Ala-His) box polypeptide 15 (DHX15), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent activity, acting on RNA TAS
    Traceable Author Statement
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2-type post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX15
    Names
    ATP-dependent RNA helicase #46
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15
    DEAD/H box-15
    DEAH (Asp-Glu-Ala-His) box helicase 15
    DEAH (Asp-Glu-Ala-His) box polypeptide 15
    DEAH box protein 15
    RNA helicase 2
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    splicing factor Prp43
    NP_001349.2
    XP_047305654.1
    XP_047305655.1
    XP_054205061.1
    XP_054205062.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358.3NP_001349.2  ATP-dependent RNA helicase DHX15

      See identical proteins and their annotated locations for NP_001349.2

      Status: REVIEWED

      Source sequence(s)
      AA771922, BC035974, BU158645
      Consensus CDS
      CCDS33966.1
      UniProtKB/Swiss-Prot
      O43143, Q9NQT7
      UniProtKB/TrEMBL
      B4E0S6
      Related
      ENSP00000336741.4, ENST00000336812.5
      Conserved Domains (1) summary
      COG1643
      Location:124763
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      24527475..24584554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449698.1XP_047305654.1  ATP-dependent RNA helicase DHX15 isoform X1

    2. XM_047449699.1XP_047305655.1  ATP-dependent RNA helicase DHX15 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      24509189..24566252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349086.1XP_054205061.1  ATP-dependent RNA helicase DHX15 isoform X1

    2. XM_054349087.1XP_054205062.1  ATP-dependent RNA helicase DHX15 isoform X2