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    KIF11 kinesin family member 11 [ Homo sapiens (human) ]

    Gene ID: 3832, updated on 28-Oct-2024

    Summary

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    Official Symbol
    KIF11provided by HGNC
    Official Full Name
    kinesin family member 11provided by HGNC
    Primary source
    HGNC:HGNC:6388
    See related
    Ensembl:ENSG00000138160 MIM:148760; AllianceGenome:HGNC:6388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EG5; HKSP; KNSL1; MCLMR; TRIP5
    Summary
    This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 9.9), bone marrow (RPKM 8.6) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF11 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92593130..92655395)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93472467..93534736)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94352887..94415152)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902484 Neighboring gene insulin degrading enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3774 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94352873-94353624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94357207-94357722 Neighboring gene ribosomal protein L11 pseudogene 4 Neighboring gene uncharacterized LOC124902594 Neighboring gene RNA, 7SL, cytoplasmic 644, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Yin Y, et al. Leuk Lymphoma, 2015 Jun. PMID 25146433
    2. KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy. Hu H, et al. Br J Ophthalmol, 2016 Feb. PMID 26472404
    3. Overexpression of Eg5 correlates with high grade astrocytic neoplasm. Liu L, et al. J Neurooncol, 2016 Jan. PMID 26456023
    4. The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma. Venere M, et al. Sci Transl Med, 2015 Sep 9. PMID 26355032, Free PMC Article
    5. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Ye XS, et al. Mol Cancer Ther, 2015 Nov. PMID 26304237

    See all (302) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eg5 UFMylation promotes spindle organization during mitosis.
      Title: Eg5 UFMylation promotes spindle organization during mitosis.
    2. Mitotic Functions and Characters of KIF11 in Cancers.
      Title: Mitotic Functions and Characters of KIF11 in Cancers.
    3. Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
      Title: Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other.
    4. KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
      Title: KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.
    5. UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
      Title: UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination.
    6. ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
      Title: ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
    7. Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
      Title: Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR.
    8. KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
      Title: KIF11 As a Potential Pan-Cancer Immunological Biomarker Encompassing the Disease Staging, Prognoses, Tumor Microenvironment, and Therapeutic Responses.
    9. A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
      Title: A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling.
    10. Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
      Title: Overexpression of kif11 is a poor prognostic factor in clear cell renal cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (146)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
    MedGen: C1835265 OMIM: 152950 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2013-08-01)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2013-08-01)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat modulates EG5 activity allosterically by blocking ADP release from EG5. Residue K85 in EG5 is important for Tat-mediated suppression of EG5 activity and Tat-induced apoptosis during mitotic arrest PubMed
    tat Pull-down/immunoprecipitation assays demonstrate that HIV-1 Tat interacts with EG5 in cells. The carboxyl-terminal domain (residues 73-101) of Tat and the amino-terminal half (residues 1-517) of EG5 are involved in the interaction between Tat and EG5 PubMed
    Vif vif HIV Vif interacts with KIF11 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic centrosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF11
    Names
    TR-interacting protein 5
    TRIP-5
    kinesin-like protein 1
    kinesin-like spindle protein HKSP
    kinesin-related motor protein Eg5
    thyroid receptor-interacting protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032580.1 RefSeqGene

      Range
      5063..67328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004523.4 → NP_004514.2  kinesin-like protein KIF11

      See identical proteins and their annotated locations for NP_004514.2

      Status: REVIEWED

      Source sequence(s)
      AA504625, BC136474, BM742618, CU446438, DB078134
      Consensus CDS
      CCDS7422.1
      UniProtKB/Swiss-Prot
      A0AV49, B2RMV3, P52732, Q15716, Q5VWX0
      UniProtKB/TrEMBL
      B2RAM6
      Related
      ENSP00000260731.3, ENST00000260731.5
      Conserved Domains (3) summary
      smart00129
      Location:18 → 366
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01364
      Location:16 → 368
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
      pfam13931
      Location:916 → 1053
      Microtub_bind; Kinesin-associated microtubule-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      92593130..92655395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      93472467..93534736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52732.2 GenPept UniProtKB/Swiss-Prot:P52732

    Gene LinkOut

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