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    EIF3A eukaryotic translation initiation factor 3 subunit A [ Homo sapiens (human) ]

    Gene ID: 8661, updated on 28-Oct-2024

    Summary

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    Official Symbol
    EIF3Aprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:3271
    See related
    Ensembl:ENSG00000107581 MIM:602039; AllianceGenome:HGNC:3271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
    Summary
    Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF3A in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119033670..119080817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119929080..119976262, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120793182..120840329, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3036 Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120654814-120655422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120718457-120719187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120719188-120719917 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120781819-120782461 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120782462-120783104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120784290-120784863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120788503-120789003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2866 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120826117-120826618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120840059-120840821 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120852323-120852823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120865335-120865834 Neighboring gene Sharpr-MPRA regulatory region 2644 Neighboring gene DENN domain containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120901959-120902460 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120924677-120924863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2869 Neighboring gene sideroflexin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex. Dong Z, et al. J Biol Chem, 2013 Sep 27. PMID 23921387, Free PMC Article
    2. eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer. Chen YX, et al. Pharmacol Res, 2021 Dec. PMID 34648968
    3. The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair. Chen J, et al. Biochem Pharmacol, 2021 Aug. PMID 34022189
    4. Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells. Zheng X, et al. Genes Genomics, 2021 Apr. PMID 33595813
    5. Circular RNA screening from EIF3a in lung cancer. Huang MS, et al. Cancer Med, 2019 Aug. PMID 31197975, Free PMC Article

    See all (296) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
      Title: The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
    2. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
      Title: eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
    3. Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
      Title: Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
    4. YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
      Title: YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
    5. eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
      Title: eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
    6. eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
      Title: eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
    7. Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
      Title: Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
    8. The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
      Title: The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
    9. LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
      Title: LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
    10. MicroRNA8755p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
      Title: MicroRNA‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in viral translational termination-reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit A
    Names
    EIF3, p180 subunit
    centrosomin homolog
    cytoplasmic protein p167
    eIF-3-theta
    eIF3 p167
    eIF3 p180
    eIF3 p185
    eukaryotic translation initiation factor 3 subunit 10
    eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
    eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
    eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
    eukaryotic translation initiation factor 3, subunit 10, 170kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003750.4 → NP_003741.1  eukaryotic translation initiation factor 3 subunit A

      See identical proteins and their annotated locations for NP_003741.1

      Status: VALIDATED

      Source sequence(s)
      AL157788, AL355598
      Consensus CDS
      CCDS7608.1
      UniProtKB/Swiss-Prot
      B1AMV5, B4DYS1, F5H335, O00653, Q14152, Q15778
      UniProtKB/TrEMBL
      Q24JU4
      Related
      ENSP00000358140.3, ENST00000369144.8
      Conserved Domains (5) summary
      smart00088
      Location:426 → 498
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      COG1196
      Location:517 → 791
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12678
      Location:910 → 1126
      PRK12678; transcription termination factor Rho; Provisional
      PRK14086
      Location:1127 → 1253
      dnaA; chromosomal replication initiator protein DnaA
      TIGR01642
      Location:1199 → 1258
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119033670..119080817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      119929080..119976262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14152.1 GenPept UniProtKB/Swiss-Prot:Q14152

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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