PRDX6 peroxiredoxin 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRDX6provided by HGNC
Official Full Name: peroxiredoxin 6provided by HGNC
Primary source: HGNC:HGNC:16753
See related: Ensembl:ENSG00000117592 MIM:602316; AllianceGenome:HGNC:16753
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m
Summary: The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q25.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (173477335..173488815)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (172835491..172846972)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (173446474..173457954)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression and clinical role of PRDX6 in lung adenocarcinoma.
Title: Expression and clinical role of PRDX6 in lung adenocarcinoma.
Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.
Title: Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.
Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population.
Title: Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population.
An Aboriginal-led consortium approach to chronic disease action for health equity and holistic wellbeing.
Title: An Aboriginal-led consortium approach to chronic disease action for health equity and holistic wellbeing.
Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration.
Title: Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration.
Integrated bioinformatics and machine learning strategies reveal PRDX6 as the key ferroptosis-associated molecular biosignature of heart failure.
Title: Integrated bioinformatics and machine learning strategies reveal PRDX6 as the key ferroptosis-associated molecular biosignature of heart failure.
PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.
Title: PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.
PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis.
Title: PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis.
Activation of the JAK1/STAT1 signaling pathway is associated with peroxiredoxin 6 expression levels in human epididymis epithelial cells.
Title: Activation of the JAK1/STAT1 signaling pathway is associated with peroxiredoxin 6 expression levels in human epididymis epithelial cells.
Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.
Title: Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify peroxiredoxin 6 (PRDX6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3439 (e-PCR)
- UniSTS:80149

G54101 (e-PCR)
- UniSTS:109338

Prdx5-rs2 (e-PCR), detects polymorphism
- UniSTS:141093

D3S2781E (e-PCR)
- UniSTS:150821

SHGC-30150 (e-PCR)
- UniSTS:22318

RH11490 (e-PCR)
- UniSTS:58683

SHGC-75911 (e-PCR)
- UniSTS:8312

SHGC-132088 (e-PCR)
- UniSTS:170637

RH25333 (e-PCR)
- UniSTS:69608

D1S2049E (e-PCR)
- UniSTS:151533

WIAF-1576 (e-PCR)
- UniSTS:59131

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular oxidant detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerophospholipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-6

Names: 1-Cys PRX; 1-Cys peroxiredoxin; 24 kDa protein; LPC acyltransferase 5; acidic calcium-independent phospholipase A2; antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; glutathione-dependent peroxiredoxin; liver 2D page spot 40; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; red blood cells page spot 12

NP_004896.1

EC 1.11.1.27

EC 2.3.1.23

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004905.3 → NP_004896.1 peroxiredoxin-6

See identical proteins and their annotated locations for NP_004896.1

Status: REVIEWED

Source sequence(s)

AL139142

Consensus CDS

CCDS1307.1

UniProtKB/Swiss-Prot

A8JZY7, P30041, P32077, Q5TAH4, Q5ZEZ8

UniProtKB/TrEMBL

A0A024R938, V9HWC7

Related

ENSP00000342026.5, ENST00000340385.6

Conserved Domains (1) summary

cd03016
Location:7 → 222

PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...