U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klhl3 kelch-like family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498697, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Symbol
    Klhl3provided by RGD
    Full Name
    kelch-like family member 3provided by RGD
    Primary source
    RGD:1565218
    See related
    EnsemblRapid:ENSRNOG00000019533 AllianceGenome:RGD:1565218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565218
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 97.4), Brain (RPKM 30.4) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Klhl3 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6528114..6651338)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6523089..6645971)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6924423..7029374)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482668 Neighboring gene uncharacterized LOC108348619 Neighboring gene heterogeneous nuclear ribonucleoprotein A0 Neighboring gene uncharacterized LOC134482666 Neighboring gene microRNA 874 Neighboring gene sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120097735

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. cMyBP-C was decreased via KLHL3-mediated proteasomal degradation in congenital heart diseases. Wang L, et al. Exp Cell Res, 2017 Jun 1. PMID 28315668
    2. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Louis-Dit-Picard H, et al. Nat Genet, 2012 Mar 11. PMID 22406640
    3. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Wakabayashi M, et al. Cell Rep, 2013 Mar 28. PMID 23453970
    4. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Shibata S, et al. Proc Natl Acad Sci U S A, 2013 May 7. PMID 23576762, Free PMC Article
    5. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cullin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in distal tubule morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in distal tubule morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in distal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in renal absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal sodium ion absorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal sodium ion absorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal sodium ion absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in renal sodium ion absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kelch-like protein 3
    Names
    kelch-like 3
    kelch-like protein 3-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419643.1 → NP_001406572.1  kelch-like protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      Related
      ENSRNOP00000081756.2, ENSRNOT00000119182.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      6528114..6651338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096443.2 → XP_038952371.1  kelch-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8D9
      Conserved Domains (4) summary
      PHA03098
      Location:24 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:405 → 450
      Kelch; KELCH repeat [structural motif]
      cd18513
      Location:121 → 250
      BACK_KLHL3; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3)
      cl38908
      Location:16 → 123
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_039096444.2 → XP_038952372.1  kelch-like protein 3 isoform X2

      Conserved Domains (4) summary
      PHA03098
      Location:88 → 335
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:200 → 245
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:59 → 103
      Kelch_1; Kelch motif
      cl28903
      Location:1 → 45
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. XM_039096445.2 → XP_038952373.1  kelch-like protein 3 isoform X3

      Conserved Domains (3) summary
      PHA03098
      Location:47 → 294
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:159 → 204
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:18 → 62
      Kelch_1; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LZ52.3 GenPept UniProtKB/Swiss-Prot:F1LZ52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools