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    Wbp1l WW domain binding protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309456, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Wbp1lprovided by RGD
    Official Full Name
    WW domain binding protein 1-likeprovided by RGD
    Primary source
    RGD:1305793
    See related
    Ensembl:ENSRNOG00000020020 AllianceGenome:RGD:1305793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Opal1; RGD1305793
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to act upstream of or within CXCL12-activated CXCR4 signaling pathway; hemopoiesis; and positive regulation of protein ubiquitination. Predicted to be integral component of membrane. Orthologous to human WBP1L (WW domain binding protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 220.1), Adrenal (RPKM 199.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wbp1l in Genome Data Viewer
    Location:
    1q54
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255413701..255470026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245472292..245528627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266358728..266415296)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 3 Neighboring gene transfer RNA histidin (anticodon AUG) Neighboring gene sideroflexin 2 Neighboring gene uncharacterized LOC120100047 Neighboring gene cytochrome P450, family 17, subfamily a, polypeptide 1 Neighboring gene uncharacterized LOC134484084 Neighboring gene BLOC-1 related complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Role of long non-coding RNA BC088414 in hypoxic-ischemic injury of neural cells]. Zhao FY, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2015 Dec. PMID 26695678
    2. Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage. Zhao F, et al. Sci Rep, 2015 Sep 9. PMID 26349411, Free PMC Article
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188498

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WW domain binding protein 1-like
    Names
    outcome predictor in acute leukemia 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127484.1 → NP_001120956.1  WW domain binding protein 1-like isoform 1 percursor precursor

      See identical proteins and their annotated locations for NP_001120956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZU54, A6JHN2, B2RYF0, F7F8B3
      Related
      ENSRNOP00000027118.5, ENSRNOT00000027118.7
      Conserved Domains (1) summary
      pfam11669
      Location:43 → 144
      WBP-1; WW domain-binding protein 1

    2. NM_001313908.1 → NP_001300837.1  WW domain binding protein 1-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, uses an alternate splice site in an internal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZU54, A0A8I6B248
      Related
      ENSRNOP00000095179.1, ENSRNOT00000110025.1
      Conserved Domains (1) summary
      pfam11669
      Location:43 → 121
      WBP-1; WW domain-binding protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255413701..255470026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080554.1 → XP_038936482.1  WW domain binding protein 1-like isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU54, A0A8I6B248
      Conserved Domains (1) summary
      pfam11669
      Location:43 → 121
      WBP-1; WW domain-binding protein 1

    2. XM_006231508.5 → XP_006231570.1  WW domain binding protein 1-like isoform X1

      See identical proteins and their annotated locations for XP_006231570.1

      UniProtKB/Swiss-Prot
      P0C1G7
      UniProtKB/TrEMBL
      A0A8I5ZU54
      Related
      ENSRNOP00000082448.1
      Conserved Domains (1) summary
      pfam11669
      Location:22 → 123
      WBP-1; WW domain-binding protein 1

    3. XM_017589294.2 → XP_017444783.1  WW domain binding protein 1-like isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU54, A0A8I6B248
      Conserved Domains (1) summary
      pfam11669
      Location:43 → 121
      WBP-1; WW domain-binding protein 1

    4. XM_039080560.2 → XP_038936488.1  WW domain binding protein 1-like isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZU54
      Conserved Domains (1) summary
      pfam11669
      Location:3 → 82
      WBP-1; WW domain-binding protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1G7.1 GenPept UniProtKB/Swiss-Prot:P0C1G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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