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    DEF8 differentially expressed in FDCP 8 homolog [ Homo sapiens (human) ]

    Gene ID: 54849, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DEF8provided by HGNC
    Official Full Name
    differentially expressed in FDCP 8 homologprovided by HGNC
    Primary source
    HGNC:HGNC:25969
    See related
    Ensembl:ENSG00000140995 AllianceGenome:HGNC:25969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in lysosome localization; positive regulation of bone resorption; and positive regulation of ruffle assembly. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 14.4), appendix (RPKM 9.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DEF8 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89948755..89968060)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (96034997..96054302)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (90015163..90034468)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene keratin-associated protein 5-1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:89984925-89985808 and GRCh37_chr16:89985809-89986692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89986693-89987576 Neighboring gene Sharpr-MPRA regulatory region 7867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89991680-89992580 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin beta 3 class III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11430 Neighboring gene small nucleolar RNA, H/ACA box 119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:90039036-90040019 Neighboring gene CENPB DNA-binding domain containing 1, pseudogene Neighboring gene AFG3 like matrix AAA peptidase subunit 1, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90054784-90054958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:90059900-90060881 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:90061681-90062880 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46884 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46891 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90066749-90066899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of autophagic protein DEF8 in Lewy bodies. Tanaka MT, et al. Biochem Biophys Res Commun, 2022 Oct 1. PMID 35921708
    2. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease. Leyton E, et al. J Alzheimers Dis, 2021. PMID 33612542
    3. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. Fujiwara T, et al. JCI Insight, 2016 Oct 20. PMID 27777970, Free PMC Article
    4. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
    5. CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system. Lim SH, et al. Mol Syst Biol, 2022 Feb. PMID 35156780, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of autophagic protein DEF8 in Lewy bodies.
      Title: Involvement of autophagic protein DEF8 in Lewy bodies.
    2. DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease.
      Title: DEF8 and Autophagy-Associated Genes Are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients, and a Transgenic Model of the Disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20186, MGC104349

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lysosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ruffle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    differentially expressed in FDCP 8 homolog
    Names
    DEF-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242816.2 → NP_001229745.1  differentially expressed in FDCP 8 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055099, AK131370, AK225539, DC332872
      Consensus CDS
      CCDS58495.1
      UniProtKB/Swiss-Prot
      Q6ZN54
      Related
      ENSP00000456799.1, ENST00000570182.5
      Conserved Domains (2) summary
      pfam13901
      Location:224 → 424
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:129 → 182
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001242817.2 → NP_001229746.1  differentially expressed in FDCP 8 homolog isoform 4

      See identical proteins and their annotated locations for NP_001229746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' UTR, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055099, AK225539, AK296410, DC332872
      Consensus CDS
      CCDS58496.1
      UniProtKB/Swiss-Prot
      Q6ZN54
      Related
      ENSP00000456095.1, ENST00000567874.5
      Conserved Domains (2) summary
      pfam13901
      Location:174 → 374
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:79 → 132
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    3. NM_001242818.2 → NP_001229747.1  differentially expressed in FDCP 8 homolog isoform 5

      See identical proteins and their annotated locations for NP_001229747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1. This difference causes translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 5) has a shorter N-terminus, compared to isoform 1. Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AK055099, AK225539, DC332872
      Consensus CDS
      CCDS58493.1
      UniProtKB/Swiss-Prot
      Q6ZN54
      Related
      ENSP00000458019.1, ENST00000563594.6
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 434
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    4. NM_001242819.1 → NP_001229748.1  differentially expressed in FDCP 8 homolog isoform 6

      See identical proteins and their annotated locations for NP_001229748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 3' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 6) has shorter N and C-termini , compared to isoform 1.
      Source sequence(s)
      AK055099, AK225539, AK295880, BC144038, DC332872
      Consensus CDS
      CCDS58494.1
      UniProtKB/Swiss-Prot
      Q6ZN54
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 417
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    5. NM_001242820.2 → NP_001229749.1  differentially expressed in FDCP 8 homolog isoform 5

      See identical proteins and their annotated locations for NP_001229749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences in the 5' UTR, compared to variant 1. This difference causes translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 5) has a shorter N-terminus, compared to isoform 1. Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AC092143, AK055099, AK225539, AK295880, DC332872
      Consensus CDS
      CCDS58493.1
      UniProtKB/Swiss-Prot
      Q6ZN54
      Related
      ENSP00000482524.1, ENST00000617948.4
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 434
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    6. NM_001242821.2 → NP_001229750.1  differentially expressed in FDCP 8 homolog isoform 2

      See identical proteins and their annotated locations for NP_001229750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
      Source sequence(s)
      AK000193, BC105592, DC332872
      Consensus CDS
      CCDS45555.1
      UniProtKB/TrEMBL
      H3BMT5
      Related
      ENSP00000480073.1, ENST00000610455.4

    7. NM_001242822.2 → NP_001229751.1  differentially expressed in FDCP 8 homolog isoform 2

      See identical proteins and their annotated locations for NP_001229751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
      Source sequence(s)
      BC015482, DC332872
      Consensus CDS
      CCDS45555.1
      UniProtKB/TrEMBL
      H3BMT5

    8. NM_017702.4 → NP_060172.1  differentially expressed in FDCP 8 homolog isoform 2

      See identical proteins and their annotated locations for NP_060172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' and 3' UTRs, compared to variant 1. These differences cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has shorter N- and C-termini, compared to isoform 1. Variants 2, 8, and 9 encode the same protein.
      Source sequence(s)
      AK000193, DC332872
      Consensus CDS
      CCDS45555.1
      UniProtKB/TrEMBL
      H3BMT5
      Related
      ENSP00000412784.2, ENST00000418391.6

    9. NM_207514.3 → NP_997397.1  differentially expressed in FDCP 8 homolog isoform 1

      See identical proteins and their annotated locations for NP_997397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092143, AK055099, AK095051, AK225539, DC332872
      Consensus CDS
      CCDS10989.1
      UniProtKB/Swiss-Prot
      B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0
      Related
      ENSP00000268676.7, ENST00000268676.11
      Conserved Domains (2) summary
      pfam13901
      Location:295 → 495
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:200 → 253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89948755..89968060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023365.2 → XP_016878854.1  differentially expressed in FDCP 8 homolog isoform X11

    2. XM_011523158.3 → XP_011521460.1  differentially expressed in FDCP 8 homolog isoform X3

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 432
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    3. XM_005256318.4 → XP_005256375.2  differentially expressed in FDCP 8 homolog isoform X4

      See identical proteins and their annotated locations for XP_005256375.2

      UniProtKB/Swiss-Prot
      Q6ZN54
      Related
      ENSP00000457627.1, ENST00000563795.1
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 417
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    4. XM_017023363.2 → XP_016878852.1  differentially expressed in FDCP 8 homolog isoform X9

      UniProtKB/Swiss-Prot
      B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0
      Conserved Domains (2) summary
      pfam13901
      Location:295 → 495
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:200 → 253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    5. XM_047434272.1 → XP_047290228.1  differentially expressed in FDCP 8 homolog isoform X11

    6. XM_017023358.3 → XP_016878847.1  differentially expressed in FDCP 8 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q6ZN54
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 434
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    7. XM_017023359.3 → XP_016878848.1  differentially expressed in FDCP 8 homolog isoform X3

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 432
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    8. XM_017023360.3 → XP_016878849.1  differentially expressed in FDCP 8 homolog isoform X4

      UniProtKB/Swiss-Prot
      Q6ZN54
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 417
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    9. XM_017023361.3 → XP_016878850.1  differentially expressed in FDCP 8 homolog isoform X7

    10. XM_017023362.3 → XP_016878851.1  differentially expressed in FDCP 8 homolog isoform X8

    11. XM_017023364.3 → XP_016878853.1  differentially expressed in FDCP 8 homolog isoform X10

    12. XM_017023367.3 → XP_016878856.1  differentially expressed in FDCP 8 homolog isoform X2

      UniProtKB/Swiss-Prot
      Q6ZN54
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 434
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    13. XM_047434273.1 → XP_047290229.1  differentially expressed in FDCP 8 homolog isoform X3

    14. XM_017023369.3 → XP_016878858.1  differentially expressed in FDCP 8 homolog isoform X4

      UniProtKB/Swiss-Prot
      Q6ZN54
      Conserved Domains (2) summary
      pfam13901
      Location:234 → 417
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    15. XM_011523161.4 → XP_011521463.1  differentially expressed in FDCP 8 homolog isoform X6

      See identical proteins and their annotated locations for XP_011521463.1

      Conserved Domains (2) summary
      pfam13901
      Location:295 → 399
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:200 → 253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    16. XM_011523160.4 → XP_011521462.1  differentially expressed in FDCP 8 homolog isoform X6

      See identical proteins and their annotated locations for XP_011521462.1

      Conserved Domains (2) summary
      pfam13901
      Location:295 → 399
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:200 → 253
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    17. XM_011523156.4 → XP_011521458.1  differentially expressed in FDCP 8 homolog isoform X1

      See identical proteins and their annotated locations for XP_011521458.1

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 338
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    18. XM_011523157.4 → XP_011521459.1  differentially expressed in FDCP 8 homolog isoform X1

      See identical proteins and their annotated locations for XP_011521459.1

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 338
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    19. XM_011523159.4 → XP_011521461.1  differentially expressed in FDCP 8 homolog isoform X5

      Conserved Domains (2) summary
      pfam13901
      Location:268 → 372
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:173 → 226
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    20. XM_011523162.4 → XP_011521464.1  differentially expressed in FDCP 8 homolog isoform X1

      See identical proteins and their annotated locations for XP_011521464.1

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 338
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    21. XM_017023366.3 → XP_016878855.1  differentially expressed in FDCP 8 homolog isoform X1

      Conserved Domains (2) summary
      pfam13901
      Location:234 → 338
      zf-RING_9; Putative zinc-RING and/or ribbon
      cl00040
      Location:139 → 192
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      96034997..96054302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380569.1 → XP_054236544.1  differentially expressed in FDCP 8 homolog isoform X11

    2. XM_054380558.1 → XP_054236533.1  differentially expressed in FDCP 8 homolog isoform X3

    3. XM_054380560.1 → XP_054236535.1  differentially expressed in FDCP 8 homolog isoform X4

    4. XM_054380567.1 → XP_054236542.1  differentially expressed in FDCP 8 homolog isoform X9

      UniProtKB/Swiss-Prot
      B3KT65, B4DK62, B4E0S9, B7Z3H6, H3BUG7, Q6ZN54, Q8N8N3, Q9NXL0

    5. XM_054380570.1 → XP_054236545.1  differentially expressed in FDCP 8 homolog isoform X11

    6. XM_054380557.1 → XP_054236532.1  differentially expressed in FDCP 8 homolog isoform X2

    7. XM_054380559.1 → XP_054236534.1  differentially expressed in FDCP 8 homolog isoform X3

    8. XM_054380561.1 → XP_054236536.1  differentially expressed in FDCP 8 homolog isoform X4

    9. XM_054380565.1 → XP_054236540.1  differentially expressed in FDCP 8 homolog isoform X7

    10. XM_054380566.1 → XP_054236541.1  differentially expressed in FDCP 8 homolog isoform X8

    11. XM_054380568.1 → XP_054236543.1  differentially expressed in FDCP 8 homolog isoform X10

    12. XM_054380573.1 → XP_054236548.1  differentially expressed in FDCP 8 homolog isoform X2

    13. XM_054380574.1 → XP_054236549.1  differentially expressed in FDCP 8 homolog isoform X3

    14. XM_054380575.1 → XP_054236550.1  differentially expressed in FDCP 8 homolog isoform X4

    15. XM_054380564.1 → XP_054236539.1  differentially expressed in FDCP 8 homolog isoform X6

    16. XM_054380563.1 → XP_054236538.1  differentially expressed in FDCP 8 homolog isoform X6

    17. XM_054380555.1 → XP_054236530.1  differentially expressed in FDCP 8 homolog isoform X1

    18. XM_054380556.1 → XP_054236531.1  differentially expressed in FDCP 8 homolog isoform X1

    19. XM_054380562.1 → XP_054236537.1  differentially expressed in FDCP 8 homolog isoform X5

    20. XM_054380571.1 → XP_054236546.1  differentially expressed in FDCP 8 homolog isoform X1

    21. XM_054380572.1 → XP_054236547.1  differentially expressed in FDCP 8 homolog isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZN54.2 GenPept UniProtKB/Swiss-Prot:Q6ZN54

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