DDX3X DEAD-box helicase 3 X-linked [Homo sapiens (human)] - Gene

Summary

Official Symbol: DDX3Xprovided by HGNC
Official Full Name: DEAD-box helicase 3 X-linkedprovided by HGNC
Primary source: HGNC:HGNC:2745
See related: Ensembl:ENSG00000215301 MIM:300160; AllianceGenome:HGNC:2745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DBX; DDX3; HLP2; DDX14; CAP-Rf; MRX102; MRXSSB
Summary: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in bone marrow (RPKM 90.6), gall bladder (RPKM 60.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.4

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (41333308..41364472)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (40735393..40766556)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (41192561..41223725)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops.
Title: Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops.
DDX3X syndrome: From clinical phenotypes to biological insights.
Title: DDX3X syndrome: From clinical phenotypes to biological insights.
Speech and language in DDX3X-neurodevelopmental disorder: A call for early augmentative and alternative communication intervention.
Title: Speech and language in DDX3X-neurodevelopmental disorder: A call for early augmentative and alternative communication intervention.
Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis.
Title: Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis.
The Role of the RNA Helicase DDX3X in Medulloblastoma Progression.
Title: The Role of the RNA Helicase DDX3X in Medulloblastoma Progression.
Determination of the Affinity of Eukaryotic DDX3 RNA Helicase to the Characteristic Elements of mRNA Secondary Structure.
Title: Determination of the Affinity of Eukaryotic DDX3 RNA Helicase to the Characteristic Elements of mRNA Secondary Structure.
A comprehensive review on DDX3X liquid phase condensation in health and neurodevelopmental disorders.
Title: A comprehensive review on DDX3X liquid phase condensation in health and neurodevelopmental disorders.
Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone.
Title: Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone.
NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity.
Title: NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity.
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
Title: AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.

Submit: New GeneRIF Correction See all GeneRIFs (164)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, X-linked 102 MedGen: C5393299 OMIM: 300958 GeneReviews: DDX3X-Related Neurodevelopmental Disorder	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2017-11-22) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2017-11-22) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed
DDX3X knockdown does not affect cell growth (HeLaP4-CCR5 cells, partial knockdown (25% of normal levels)) but significantly impairs HIV-1 replication; HIV-1 replication is enhanced by DDX3X	PubMed
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X) by siRNA inhibits HIV-1 replication in HeLa P4/CCR5 cells	PubMed
Knockdown of ATP-dependent RNA helicase DDX3X by siRNAs inhibits HIV-1 replication in CD4+ T cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify X-linked DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 (DDX3X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify X-linked DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 (DDX3X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify X-linked DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 (DDX3X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Cellular biotinylated DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X) protein is incorporated into HIV-1 Gag virus-like particles	PubMed
	gag	Tandem affinity purification and mass spectrometry analysis identify X-linked DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 (DDX3X), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	HIV-1 Rev function is inhibited by DDX3X expression in astrocytes	PubMed
	rev	Computational molecular docking, alanine scanning, clustering, and evolutionary analysis reveal the interaction of DDX3 with HIV-1 Rev-CRM1-RanGTP complex	PubMed
	rev	Coexpression of HIV-1 Rev with DDX3 greatly upregulate the expression of HIV-1 CA in HeLa cells	PubMed
	rev	DDX3 interacts with DDX1 or DDX5 and synergistically enhances the Rev function	PubMed
	rev	DDX3 interacts with HIV-1 Rev and enhances the Rev function. DDX3 co-localizes with Rev in both nucleolus and cytoplasm	PubMed
	rev	Translation of HIV-1 early regulatory proteins Tat and Rev is impaired in DDX3-depleted cells. The RNA helicase activity of DDX3 is required for its function in HIV-1 mRNA translation via 5'UTRs	PubMed
	rev	As part of the HIV-1 Rev-RRE/CRM1 pathway, DDX3, an RNA-dependent ATPase/helicase, locates to nuclear pores and binds CRM1 in order to export Rev and unspliced/partially spliced HIV-1 transcripts to the cytoplasm	PubMed
	rev	HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 X-linked (DDX3X), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DDX3X is increased by RRE	PubMed
Tat	tat	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (DDX3) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS	PubMed
	tat	DDX3 enhances the HIV-1 Tat-induced transcription and co-localizes with Tat in cytoplasmic foci in 293FT cells	PubMed
	tat	Translation of HIV-1 early regulatory proteins Tat and Rev is impaired in DDX3-depleted cells. The RNA helicase activity of DDX3 is required for its function in HIV-1 mRNA translation via 5'UTRs	PubMed
	tat	HIV-1 Tat co-localizes with DDX3 in cytoplasmic stress granules under stree conditions	PubMed
	tat	HIV-1 Tat binds DDX3 in vitro and in vivo. The C-terminal region (residues 536-661) of DDX3 is responsible for Tat binding	PubMed
capsid	gag	Coexpression of HIV-1 Rev with DDX3 greatly upregulate the expression of HIV-1 CA in HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-33274 (e-PCR)
- UniSTS:167681

DXS7525 (e-PCR)
- UniSTS:50435

DDX3 (e-PCR)
- UniSTS:278276

Ddx3 (e-PCR), detects polymorphism
- UniSTS:255281

U42386 (e-PCR)
- UniSTS:125746

NoName (e-PCR)
- UniSTS:51773

DDX3X (e-PCR)
- UniSTS:280393

G34988 (e-PCR)
- UniSTS:35711

RH78345 (e-PCR)
- UniSTS:34689

Ddx3 (e-PCR), detects polymorphism
- UniSTS:256392

G41926 (e-PCR)
- UniSTS:55188

DBX (e-PCR)
- UniSTS:266902

G49473 (e-PCR)
- UniSTS:109215

DDX3X (e-PCR)
- UniSTS:506560

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables CTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA strand annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	IDA Inferred from Direct Assay more info	PubMed
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(A) binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in RNA secondary structure unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytosolic ribosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of interferon-alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of mitochondrial translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of toll-like receptor 7 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of toll-like receptor 8 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cytoplasmic stress granule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in stress granule assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP3 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX3X

Names: DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; helicase-like protein 2

NP_001180345.1

EC 3.6.4.13

NP_001180346.1

EC 3.6.4.13

NP_001347.3

EC 3.6.4.13

NP_001350748.1

EC 3.6.4.13

XP_011542194.1

EC 3.6.4.13

XP_054182567.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012830.2 RefSeqGene

Range

5765..21877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001193416.3 → NP_001180345.1 ATP-dependent RNA helicase DDX3X isoform 2

See identical proteins and their annotated locations for NP_001180345.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AF061337, AL391647, AU144400, BC007668, BQ921695, DA232063

Consensus CDS

CCDS87734.1

UniProtKB/TrEMBL

A0A2R8YFS5, B5BTY4

Related

ENSP00000495377.1, ENST00000646319.1

Conserved Domains (2) summary

PTZ00110
Location:57 → 597

PTZ00110; helicase; Provisional

cd18051
Location:160 → 410

DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
NM_001193417.3 → NP_001180346.1 ATP-dependent RNA helicase DDX3X isoform 3

See identical proteins and their annotated locations for NP_001180346.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK304689, AL391647, AU144400, BC007668, BQ921695

Consensus CDS

CCDS55404.1

UniProtKB/TrEMBL

A0A2R8YFR4, B5BTY4

Related

ENSP00000392494.2, ENST00000457138.7

Conserved Domains (2) summary

COG0513
Location:140 → 557

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

pfam06273
Location:69 → 161

eIF-4B; Plant specific eukaryotic initiation factor 4B
NM_001356.5 → NP_001347.3 ATP-dependent RNA helicase DDX3X isoform 1

See identical proteins and their annotated locations for NP_001347.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK291153, AU144400, BC007668, BM454841

Consensus CDS

CCDS43931.1

UniProtKB/Swiss-Prot

A8K538, B4E3E8, O00571, O15536

UniProtKB/TrEMBL

B5BTY4

Related

ENSP00000494040.1, ENST00000644876.2

Conserved Domains (2) summary

PTZ00110
Location:57 → 580

PTZ00110; helicase; Provisional

cd18051
Location:160 → 410

DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3
NM_001363819.1 → NP_001350748.1 ATP-dependent RNA helicase DDX3X isoform 4

Status: REVIEWED

Source sequence(s)

AL391647

Consensus CDS

CCDS87736.1

UniProtKB/TrEMBL

A0A2R8Y774, A0A2R8Y7T2, A0A2R8YDT5

Related

ENSP00000494887.1, ENST00000646679.1

Conserved Domains (2) summary

cd18787
Location:229 → 359

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd18051
Location:1 → 224

DEADc_DDX3; DEAD-box helicase domain of DEAD box protein 3

RNA

NR_126093.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF000983, AK291153, BF980241, DA232063, DB065845
NR_126094.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' exon, lacks multiple internal exons, and uses an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AA481139, AL391647, BC055083

Related

ENST00000643821.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

41333308..41364472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011543892.3 → XP_011542194.1 ATP-dependent RNA helicase DDX3X isoform X1

UniProtKB/TrEMBL

A0A0D9SFB3

Related

ENSP00000494588.1, ENST00000645589.1

Conserved Domains (2) summary

COG0513
Location:156 → 573

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

pfam06273
Location:85 → 177

eIF-4B; Plant specific eukaryotic initiation factor 4B

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

40735393..40766556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326592.1 → XP_054182567.1 ATP-dependent RNA helicase DDX3X isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_024005.1: Suppressed sequence

Description

NM_024005.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.