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    INPPL1 inositol polyphosphate phosphatase like 1 [ Homo sapiens (human) ]

    Gene ID: 3636, updated on 14-Nov-2024

    Summary

    Official Symbol
    INPPL1provided by HGNC
    Official Full Name
    inositol polyphosphate phosphatase like 1provided by HGNC
    Primary source
    HGNC:HGNC:6080
    See related
    Ensembl:ENSG00000165458 MIM:600829; AllianceGenome:HGNC:6080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OPSMD; SHIP2
    Summary
    The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 19.8), thyroid (RPKM 19.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See INPPL1 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72223563..72239147)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72149924..72165764)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71935811..71950191)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3717 Neighboring gene folate receptor beta Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3718 Neighboring gene paired like homeobox 2A Neighboring gene dedicator of cytokinesis 1 pseudogene Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Opsismodysplasia
    MedGen: C0432219 OMIM: 258480 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding PubMed 
    enables SH3 domain binding  
    enables actin binding  
    enables inositol-polyphosphate 5-phosphatase activity  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade  
    involved_in actin filament organization PubMed 
    involved_in apoptotic process  
    involved_in cell adhesion PubMed 
    involved_in endochondral ossification PubMed 
    involved_in endocytosis PubMed 
    involved_in establishment of mitotic spindle orientation  
    involved_in gene expression  
    involved_in glucose metabolic process  
    involved_in immune system process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol biosynthetic process  
    involved_in phosphatidylinositol dephosphorylation  
    involved_in post-embryonic development  
    involved_in regulation of actin filament organization  
    involved_in regulation of immune response  
    involved_in regulation of protein localization  
    involved_in response to insulin  
    involved_in ruffle assembly  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in basal plasma membrane  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in filopodium  
    located_in lamellipodium  
    located_in nuclear speck  
    located_in nucleus  
    located_in spindle pole  

    General protein information

    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
    Names
    51C protein
    INPPL-1
    SH2 domain-containing inositol-5'-phosphatase 2
    SHIP-2
    protein 51C
    NP_001558.3
    XP_005274036.1
    XP_011543301.1
    XP_047282843.1
    XP_047282844.1
    XP_047282845.1
    XP_047282846.1
    XP_047282847.1
    XP_047282848.1
    XP_047282849.1
    XP_054224654.1
    XP_054224655.1
    XP_054224656.1
    XP_054224657.1
    XP_054224658.1
    XP_054224659.1
    XP_054224660.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023253.2 RefSeqGene

      Range
      4930..19310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001567.4NP_001558.3  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

      See identical proteins and their annotated locations for NP_001558.3

      Status: REVIEWED

      Source sequence(s)
      AP000593, BC140853, BG236320, Y14385
      Consensus CDS
      CCDS8213.1
      UniProtKB/Swiss-Prot
      B2RTX5, O15357, Q13577, Q13578
      Related
      ENSP00000298229.2, ENST00000298229.7
      Conserved Domains (4) summary
      cd09491
      Location:11941256
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:424727
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12021258
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72223563..72239147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426888.1XP_047282844.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    2. XM_047426890.1XP_047282846.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

      UniProtKB/Swiss-Prot
      B2RTX5, O15357, Q13577, Q13578
    3. XM_047426887.1XP_047282843.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    4. XM_005273979.5XP_005274036.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_005274036.1

      Conserved Domains (4) summary
      cd09491
      Location:12161278
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:446749
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12241280
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    5. XM_047426891.1XP_047282847.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

    6. XM_011544999.3XP_011543301.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

      See identical proteins and their annotated locations for XP_011543301.1

      UniProtKB/Swiss-Prot
      B2RTX5, O15357, Q13577, Q13578
      Conserved Domains (4) summary
      cd09491
      Location:11941256
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:424727
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:12021258
      SAM; Sterile alpha motif
      cd10343
      Location:17119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    7. XM_047426892.1XP_047282848.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

    8. XM_047426889.1XP_047282845.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    9. XM_047426893.1XP_047282849.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

      Related
      ENSP00000444619.1, ENST00000538751.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      72149924..72165764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368682.1XP_054224657.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    2. XM_054368679.1XP_054224654.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    3. XM_054368683.1XP_054224658.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

    4. XM_054368681.1XP_054224656.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

    5. XM_054368684.1XP_054224659.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

    6. XM_054368680.1XP_054224655.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

    7. XM_054368685.1XP_054224660.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X5

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