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    FPR1 formyl peptide receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2357, updated on 2-Nov-2024

    Summary

    Official Symbol
    FPR1provided by HGNC
    Official Full Name
    formyl peptide receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3826
    See related
    Ensembl:ENSG00000171051 MIM:136537; AllianceGenome:HGNC:3826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPR; FMLP
    Summary
    This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
    Expression
    Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FPR1 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51745172..51751878, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54832367..54839072, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52248425..52255131, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene hyaluronan synthase 1 Neighboring gene uncharacterized LOC124904754 Neighboring gene Sharpr-MPRA regulatory region 4853 Neighboring gene formyl peptide receptor 2 Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene uncharacterized LOC105372448

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes PubMed
    env N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity PubMed 
    enables G protein-coupled receptor binding PubMed 
    enables N-formyl peptide receptor activity  
    enables N-formyl peptide receptor activity PubMed 
    enables RAGE receptor binding  
    enables complement receptor activity  
    enables protein binding PubMed 
    enables scavenger receptor binding  
    Component Evidence Code Pubs
    located_in azurophil granule membrane  
    located_in cytoplasm  
    located_in ficolin-1-rich granule membrane  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in secretory granule membrane  

    General protein information

    Preferred Names
    fMet-Leu-Phe receptor
    Names
    N-formylpeptide chemoattractant receptor
    fMLP receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023426.1 RefSeqGene

      Range
      5001..11128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_146

    mRNA and Protein(s)

    1. NM_001193306.2NP_001180235.1  fMet-Leu-Phe receptor

      See identical proteins and their annotated locations for NP_001180235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC018755
      Consensus CDS
      CCDS12839.1
      UniProtKB/Swiss-Prot
      P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48
      UniProtKB/TrEMBL
      B2RC44
      Related
      ENSP00000471493.1, ENST00000595042.5
      Conserved Domains (2) summary
      cd14964
      Location:2953
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_002029.4NP_002020.1  fMet-Leu-Phe receptor

      See identical proteins and their annotated locations for NP_002020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC005315, BQ016000, M60627
      Consensus CDS
      CCDS12839.1
      UniProtKB/Swiss-Prot
      P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48
      UniProtKB/TrEMBL
      B2RC44
      Related
      ENSP00000302707.3, ENST00000304748.5
      Conserved Domains (2) summary
      cd14964
      Location:2953
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27312
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51745172..51751878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54832367..54839072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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