NEW
Try the new Transcript table
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011717.2Â RefSeqGene
- Range
-
5044..53255
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_591
mRNA and Protein(s)
-
NM_000014.6 → NP_000005.3  alpha-2-macroglobulin isoform a precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
- Source sequence(s)
-
AC007436
- Consensus CDS
-
CCDS44827.1
- UniProtKB/Swiss-Prot
- P01023, Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
- Related
- ENSP00000323929.8, ENST00000318602.12
- Conserved Domains (7) summary
-
- cd02897
Location:958 → 1264
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:738 → 828
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:129 → 221
- A2M_N; MG2 domain
- pfam07677
Location:1376 → 1463
- A2M_recep; A-macroglobulin receptor
- pfam07703
Location:459 → 607
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
- pfam17789
Location:350 → 445
- MG4; Macroglobulin domain MG4
- pfam17791
Location:223 → 313
- MG3; Macroglobulin domain MG3
-
NM_001347423.2 → NP_001334352.2  alpha-2-macroglobulin isoform a precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) splices out a region of the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
- Source sequence(s)
-
AC007436
- Consensus CDS
-
CCDS44827.1
- UniProtKB/Swiss-Prot
- P01023, Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
- Conserved Domains (7) summary
-
- cd02897
Location:958 → 1264
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:738 → 828
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:129 → 221
- A2M_N; MG2 domain
- pfam07677
Location:1376 → 1463
- A2M_recep; A-macroglobulin receptor
- pfam07703
Location:459 → 607
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
- pfam17789
Location:350 → 445
- MG4; Macroglobulin domain MG4
- pfam17791
Location:223 → 313
- MG3; Macroglobulin domain MG3
-
NM_001347424.2 → NP_001334353.2  alpha-2-macroglobulin isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
- Source sequence(s)
-
AC007436
- Conserved Domains (7) summary
-
- cd02897
Location:858 → 1164
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:638 → 728
- A2M; Alpha-2-macroglobulin family
- pfam07677
Location:1276 → 1363
- A2M_recep; A-macroglobulin receptor
- pfam17789
Location:250 → 345
- MG4; Macroglobulin domain MG4
- pfam17791
Location:123 → 210
- MG3; Macroglobulin domain MG3
- pfam01835
Location:29 → 121
- A2M_N; MG2 domain
- pfam07703
Location:359 → 507
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
-
NM_001347425.2 → NP_001334354.2  alpha-2-macroglobulin isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks an exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
- Source sequence(s)
-
AC007436
- Conserved Domains (7) summary
-
- cd02897
Location:808 → 1114
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:588 → 678
- A2M; Alpha-2-macroglobulin family
- pfam07677
Location:1226 → 1313
- A2M_recep; A-macroglobulin receptor
- pfam17789
Location:200 → 295
- MG4; Macroglobulin domain MG4
- pfam17791
Location:73 → 160
- MG3; Macroglobulin domain MG3
- pfam01835
Location:1 → 71
- A2M_N; MG2 domain
- pfam07703
Location:309 → 457
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12Â Reference GRCh38.p14 Primary Assembly
- Range
-
9067708..9116229 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006719056.4 → XP_006719119.1  alpha-2-macroglobulin isoform X1
- Conserved Domains (7) summary
-
- COG2373
Location:124 → 1071
- YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
- cd02897
Location:958 → 1264
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:738 → 828
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:129 → 221
- A2M_N; MG2 domain
- pfam07677
Location:1376 → 1463
- A2M_recep; A-macroglobulin receptor
- pfam07678
Location:1010 → 1266
- A2M_comp; A-macroglobulin complement component
- pfam07703
Location:461 → 606
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1Â Alternate T2T-CHM13v2.0
- Range
-
9049893..9098416 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054371391.1 → XP_054227366.1  alpha-2-macroglobulin isoform X1