PPARG peroxisome proliferator activated receptor gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPARGprovided by HGNC
Official Full Name: peroxisome proliferator activated receptor gammaprovided by HGNC
Primary source: HGNC:HGNC:9236
See related: Ensembl:ENSG00000132170 MIM:601487; AllianceGenome:HGNC:9236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLM1; CIMT1; FPLD3; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in fat (RPKM 44.7), urinary bladder (RPKM 10.3) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p25.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (12287368..12434344)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (12285564..12432191)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (12328867..12475843)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring the molecular pathways of the activation process in PPARgamma recurrent bladder cancer mutants.
Title: Exploring the molecular pathways of the activation process in PPARγ recurrent bladder cancer mutants.
HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains.
Title: HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains.
Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-alpha-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor gamma and Suppression of NF-kappaB p65.
Title: Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α-Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex-Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65.
The Loss of PPARgamma Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation.
Title: The Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation.
Deletion of CD44 promotes adipogenesis by regulating PPARgamma and cell cycle-related pathways.
Title: Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways.
Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis.
Title: Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis.
Association between genetically proxied PPARG activation and psoriasis vulgaris: a Mendelian randomization study.
Title: Association between genetically proxied PPARG activation and psoriasis vulgaris: a Mendelian randomization study.
PPARgamma regulates osteoarthritis chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway.
Title: PPARγ regulates osteoarthritis chondrocytes apoptosis through caspase-3 dependent mitochondrial pathway.
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis.
Title: PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis.
PPARgamma dependent PEX11beta counteracts the suppressive role of SIRT1 on neural differentiation of HESCs.
Title: PPARgamma dependent PEX11beta counteracts the suppressive role of SIRT1 on neural differentiation of HESCs.

Submit: New GeneRIF Correction See all GeneRIFs (1789)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Carotid intimal medial thickness 1 MedGen: C1836302 OMIM: 609338 GeneReviews: Not available	not available
Inherited obesity MedGen: C4054476 OMIM: 601665 GeneReviews: Not available	not available
PPARG-related familial partial lipodystrophy MedGen: C1720861 OMIM: 604367 GeneReviews: Not available	not available
Type 2 diabetes mellitus MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder	not available

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates PPARgamma expression in human mesenchymal stem cells	PubMed
	env	In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity	PubMed
Nef	nef	HIV-1 Nef suppresses PPAR-gamma expression in human T and macrophage cell lines, and the effects of PPAR-gamma on viral replication is reduced by co-expression of Nef in MT4 T cells	PubMed
Pr55(Gag)	gag	In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity	PubMed
Tat	tat	HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells	PubMed
	tat	Sera from high viral load HIV-1-infected individuals induce a clear proadipogenic phenotype with increased expression of adipogenic markers including LPL and PPARgamma by HIV-1 Tat-mediated inhibition of COUP TF-1	PubMed
	tat	HIV-1 Tat enhances the differentiation of mesenchymal stem cells (MSC) toward adipogenesis by the transcription and activity upregulation of PPARgamma	PubMed
	tat	The endogenous PPARgamma ligand 15d-PGJ2 inhibits HIV-1 Tat-induced MCP-1 production in human microglia-like cells	PubMed
	tat	PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB	PubMed
	tat	Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin	PubMed
Vif	vif	HIV-1 Vif downregulates the expression of peroxisome proliferator-activated receptor gamma (PPARG) in Vif-expression T cells	PubMed
matrix	gag	HIV-1 MA downregulates PPARG gene expression in HepG2 cells	PubMed
	gag	Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC22700P1 (e-PCR)
- UniSTS:272146

PMC84391P1 (e-PCR)
- UniSTS:273444

PMC310777P12 (e-PCR)
- UniSTS:272679

PMC310777P13 (e-PCR)
- UniSTS:272680

SHGC-145535 (e-PCR)
- UniSTS:174634

RH12621 (e-PCR)
- UniSTS:28459

SHGC-144700 (e-PCR)
- UniSTS:172365

PPARG (e-PCR)
- UniSTS:479835

RH121417 (e-PCR)
- UniSTS:134264

WI-20399 (e-PCR)
- UniSTS:26501

RH10742 (e-PCR)
- UniSTS:20620

GDB:451806 (e-PCR)
- UniSTS:157373

PMC137581P1 (e-PCR)
- UniSTS:270844

PMC137581P2 (e-PCR)
- UniSTS:270845

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding domain binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables LBD domain binding	IDA Inferred from Direct Assay more info	PubMed
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables WW domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-actinin binding	IPI Inferred from Physical Interaction more info	PubMed
enables arachidonate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	EXP Inferred from Experiment more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in lipid homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in lipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in lipoprotein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of long-chain fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy in response to stress	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of connective tissue replacement involved in inflammatory response wound healing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of extracellular matrix assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome proliferator activated receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in placenta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of adiponectin secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of adipose tissue development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of positive regulation of low-density lipoprotein receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to insulin stimulus	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipid	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to nutrient	TAS Traceable Author Statement more info	PubMed
involved_in retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in white fat cell differentiation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma

Names: PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor-gamma 5; peroxisome proliferator-activated receptor-gamma splicing

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011749.1 RefSeqGene

Range

6221..151495

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001330615.4 → NP_001317544.2 peroxisome proliferator-activated receptor gamma isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and lacks an alternate exon in the 3' coding region, resulting in a frameshift and different 3' UTR, compared to variant 2. It encodes isoform 3, which is shorter and contains distinct N- and C-termini, compared to isoform 2. Variants 5, 11, and 12 all encode the same isoform (3).

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS87046.2

UniProtKB/TrEMBL

A0A494C1F9, E9PFX5, Q4W448

Related

ENSP00000380196.2, ENST00000397000.6

Conserved Domains (3) summary

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:207 → 243

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001354666.3 → NP_001341595.2 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1, 3, 4, 7, 13, and 14, encodes isoform 1.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Related

ENSP00000380205.3, ENST00000397010.7

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001354667.3 → NP_001341596.2 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 1, 3, 4, 6, 13, and 14, encodes isoform 1.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001354668.2 → NP_001341597.1 peroxisome proliferator-activated receptor gamma isoform 4

Status: REVIEWED

Source sequence(s)

AC090947, AC093174, AJ563369

UniProtKB/TrEMBL

Q4W4C7

Conserved Domains (3) summary

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:237 → 274

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001354669.2 → NP_001341598.1 peroxisome proliferator-activated receptor gamma isoform 5

Status: REVIEWED

Source sequence(s)

AC090947, AC091492, AC093174

Conserved Domains (1) summary

cd06932
Location:34 → 265

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
NM_001354670.2 → NP_001341599.1 peroxisome proliferator-activated receptor gamma isoform 6

Status: REVIEWED

Source sequence(s)

AC090947, AC091492, AJ563370

UniProtKB/TrEMBL

Q4W4C6

Conserved Domains (3) summary

cd06965
Location:110 → 193

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:3 → 80

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:209 → 246

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001374261.3 → NP_001361190.2 peroxisome proliferator-activated receptor gamma isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variants 5 and 12, encodes isoform 3.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS87046.2

UniProtKB/TrEMBL

A0A494C1F9, E9PFX5, Q4W448

Conserved Domains (3) summary

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:207 → 243

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001374262.3 → NP_001361191.2 peroxisome proliferator-activated receptor gamma isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 5 and 11, encodes isoform 3.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS87046.2

UniProtKB/TrEMBL

A0A494C1F9, E9PFX5, Q4W448

Conserved Domains (3) summary

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:207 → 243

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001374263.2 → NP_001361192.2 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 1, 3, 4, 6, 7, and 14, encodes isoform 1.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Related

ENSP00000507893.1, ENST00000683586.1

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001374264.2 → NP_001361193.2 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 1, 3, 4, 6, 7, and 13, encodes isoform 1.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_001374265.1 → NP_001361194.1 peroxisome proliferator-activated receptor gamma isoform 7

Status: REVIEWED

Source sequence(s)

AC090947, AC093174

Consensus CDS

CCDS93212.1

UniProtKB/TrEMBL

A0A3P3ZKM0, A0A494C1F9

Related

ENSP00000507823.1, ENST00000683699.1

Conserved Domains (3) summary

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region

cl11397
Location:237 → 273

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001374266.1 → NP_001361195.1 peroxisome proliferator-activated receptor gamma isoform 8

Status: REVIEWED

Source sequence(s)

AC090947, AC091492, AC093174

UniProtKB/TrEMBL

A0A494C1F9

Conserved Domains (2) summary

cd06965
Location:110 → 193

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:3 → 80

PPARgamma_N; PPAR gamma N-terminal region
NM_005037.7 → NP_005028.5 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Related

ENSP00000380210.3, ENST00000397015.7

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_015869.5 → NP_056953.2 peroxisome proliferator-activated receptor gamma isoform 2

See identical proteins and their annotated locations for NP_056953.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AC090947, AC093174

Consensus CDS

CCDS2609.1

UniProtKB/Swiss-Prot

A8K3G6, B5BUA1, O00684, O00710, O14515, P37231, Q0QJH8, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12

UniProtKB/TrEMBL

D2KUA6, Q53EW1

Related

ENSP00000287820.6, ENST00000287820.10

Conserved Domains (3) summary

cd06932
Location:237 → 504

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region
NM_138711.6 → NP_619725.3 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Related

ENSP00000498313.1, ENST00000651735.1

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
NM_138712.5 → NP_619726.3 peroxisome proliferator-activated receptor gamma isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.

Source sequence(s)

AC090947, AC091492, AC093174

Consensus CDS

CCDS2610.3

UniProtKB/TrEMBL

D2KUA6, E9PFV2

Related

ENSP00000312472.7, ENST00000309576.11

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region