U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    MTBP MDM2 binding protein [ Homo sapiens (human) ]

    Gene ID: 27085, updated on 2-Nov-2024

    Summary

    Official Symbol
    MTBPprovided by HGNC
    Official Full Name
    MDM2 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:7417
    See related
    Ensembl:ENSG00000172167 MIM:605927; AllianceGenome:HGNC:7417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDM2BP
    Summary
    This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in testis (RPKM 2.1), lymph node (RPKM 1.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MTBP in Genome Data Viewer
    Location:
    8q24.12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (120445419..120523636)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (121574164..121652088)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121457659..121535876)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:121250945-121251444 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:121278472-121279056 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:121409422-121409610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:121409635-121410134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27849 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:121567323-121568522 Neighboring gene syntrophin beta 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:121637686-121638215 Neighboring gene non-SMC condensin I complex subunit G pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:121697522-121698069 Neighboring gene uncharacterized LOC101927543

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin PubMed 
    is_active_in kinetochore  
    located_in kinetochore PubMed 

    General protein information

    Preferred Names
    mdm2-binding protein
    Names
    MDM2 (mouse double minute 2)-binding protein, 104kD
    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033151.1 RefSeqGene

      Range
      5022..83239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022045.5NP_071328.2  mdm2-binding protein

      See identical proteins and their annotated locations for NP_071328.2

      Status: REVIEWED

      Source sequence(s)
      AC105142, AC107877, BC013136
      Consensus CDS
      CCDS6333.1
      UniProtKB/Swiss-Prot
      B4DUR5, Q96DY7, Q9HA89
      Related
      ENSP00000303398.1, ENST00000305949.6
      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294632
      MTBP_mid; MDM2-binding
      pfam14920
      Location:636894
      MTBP_C; MDM2-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      120445419..120523636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516962.3XP_011515264.1  mdm2-binding protein isoform X1

      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294632
      MTBP_mid; MDM2-binding
      pfam14920
      Location:636660
      MTBP_C; MDM2-binding
    2. XM_011516963.3XP_011515265.1  mdm2-binding protein isoform X2

      Conserved Domains (2) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:294483
      MTBP_mid; MDM2-binding

    RNA

    1. XR_928318.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      121574164..121652088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360293.1XP_054216268.1  mdm2-binding protein isoform X1

    2. XM_054360294.1XP_054216269.1  mdm2-binding protein isoform X2

    RNA

    1. XR_008487835.1 RNA Sequence

    External link. Please review our privacy policy.