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    SNAP91 synaptosome associated protein 91 [ Homo sapiens (human) ]

    Gene ID: 9892, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SNAP91provided by HGNC
    Official Full Name
    synaptosome associated protein 91provided by HGNC
    Primary source
    HGNC:HGNC:14986
    See related
    Ensembl:ENSG00000065609 MIM:607923; AllianceGenome:HGNC:14986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALM; AP180
    Summary
    Predicted to enable several functions, including clathrin adaptor activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 42.7), testis (RPKM 6.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See SNAP91 in Genome Data Viewer
    Location:
    6q14.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83552885..83709393, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84776120..84932636, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (84262604..84419112, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5928 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene malic enzyme 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:84140986-84142185 Neighboring gene serine protease 35 Neighboring gene Sharpr-MPRA regulatory region 13924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17360 Neighboring gene uncharacterized LOC105377879 Neighboring gene RIPPLY2-CYB5R4 readthrough Neighboring gene MPRA-validated peak5930 silencer Neighboring gene ripply transcriptional repressor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. Yao PJ, et al. Neuroscience, 1999. PMID 10579202
    2. Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain. Murphy JE, et al. J Biol Chem, 1994 Aug 19. PMID 8063760
    3. Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain. Yao PJ, et al. Neurobiol Aging, 2003 Jan-Feb. PMID 12493563
    4. Turning CALM into excitement: AP180 and CALM in endocytosis and disease. Maritzen T, et al. Biol Cell, 2012 Oct. PMID 22639918
    5. Intrinsically disordered proteins drive membrane curvature. Busch DJ, et al. Nat Commun, 2015 Jul 24. PMID 26204806, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study concludes that the novel clathrin interaction sites identified here in CALM and AP180 have a major role in how these proteins interface with clathrin. This work advances the case that AP180 and CALM are required to use a combination of standard clathrin N-terminal domain binding motifs and the sequence identified here for optimal binding and assembling clathrin.
      Title: A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.
    2. intrinsically disordered domains are highly potent drivers of membrane curvature
      Title: Intrinsically disordered proteins drive membrane curvature.
    3. To sustain efficient neurotransmission and synaptic vesicle formation, AP180 and VAMP2 are required.
      Title: Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.
    4. AP180 and CALM are endocytic adaptors dedicated to the sorting of small soluble N-ethylmaleimide-sensitive-factor attachment protein receptors. (Review)
      Title: Turning CALM into excitement: AP180 and CALM in endocytosis and disease.
    5. unique mechanism of SNARE motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin endocytosis
      Title: SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.
    6. AP180 is significantly decreased in the hippocampus of Alzheimer's disease patients and in hippocampal neurons of transgenic mice.
      Title: Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. RNA interference-mediated knockdown of AP180 reduces the generation of Abeta1-40 and Abeta1-42, whereas CALM knockdown has no effect on Abeta generation.
      Title: The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Novel cleft susceptibility genes in chromosome 6q.
    10. AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize.
      Title: Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu The C-terminal fragment of the clathrin assembly protein AP180 inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu and HIV-2 Env PubMed
    capsid gag AP180 depletion by shRNA results in inhibition of the HIV-1 CA uptake by target cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0656, DKFZp781O0519

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    clathrin coat assembly protein AP180
    Names
    91 kDa synaptosomal-associated protein
    assembly protein, 180kDa
    clathrin coat-associated protein AP180
    phosphoprotein F1-20
    synaptosomal-associated protein, 91kDa homolog
    synaptosome associated protein 91kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242792.2 → NP_001229721.1  clathrin coat assembly protein AP180 isoform a

      See identical proteins and their annotated locations for NP_001229721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AB014556, AK289582, AL109915, BC044579
      Consensus CDS
      CCDS47455.1
      UniProtKB/Swiss-Prot
      A8K0L7, E5RI02, O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7
      Related
      ENSP00000358708.2, ENST00000369694.7
      Conserved Domains (2) summary
      pfam07651
      Location:21 → 284
      ANTH; ANTH domain
      cl26464
      Location:595 → 897
      Atrophin-1; Atrophin-1 family

    2. NM_001242793.2 → NP_001229722.1  clathrin coat assembly protein AP180 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal segment in the 5' UTR and two in-frame exons in the CDS, compared to variant 1. The resulting isoform (b) lacks two internal segments, compared to isoform a. Variants 4 and 42-45 all encode the same isoform (b).
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56438.1
      UniProtKB/Swiss-Prot
      O60641
      Related
      ENSP00000428511.1, ENST00000520302.5
      Conserved Domains (2) summary
      PHA03247
      Location:697 → 867
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    3. NM_001242794.2 → NP_001229723.1  clathrin coat assembly protein AP180 isoform c

      See identical proteins and their annotated locations for NP_001229723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR and multiple exons in the CDS, compared to variant 1. The resulting isoform (c) lacks three internal segments, compared to isoform a.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56437.1
      UniProtKB/Swiss-Prot
      O60641
      Related
      ENSP00000428026.1, ENST00000520213.5
      Conserved Domains (2) summary
      pfam07651
      Location:21 → 270
      ANTH; ANTH domain
      cl26464
      Location:282 → 590
      Atrophin-1; Atrophin-1 family

    4. NM_001256717.2 → NP_001243646.1  clathrin coat assembly protein AP180 isoform d

      See identical proteins and their annotated locations for NP_001243646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AL109915
      UniProtKB/Swiss-Prot
      O60641
      Conserved Domains (1) summary
      pfam07651
      Location:10 → 249
      ANTH; ANTH domain

    5. NM_001256718.2 → NP_001243647.1  clathrin coat assembly protein AP180 isoform e

      See identical proteins and their annotated locations for NP_001243647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AK294898, AL109915, BC036650, BC044579, CR749348, DA307867
      UniProtKB/TrEMBL
      B7Z2C2, B7Z2N2
      Conserved Domains (1) summary
      cl02544
      Location:1 → 165
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

    6. NM_001363677.2 → NP_001350606.1  clathrin coat assembly protein AP180 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS87418.1
      UniProtKB/TrEMBL
      E9PDG8
      Related
      ENSP00000195649.6, ENST00000195649.10
      Conserved Domains (2) summary
      pfam07651
      Location:21 → 284
      ANTH; ANTH domain
      cl26464
      Location:671 → 892
      Atrophin-1; Atrophin-1 family

    7. NM_001376675.1 → NP_001363604.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 10-16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    8. NM_001376676.1 → NP_001363605.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 9 and 11-16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    9. NM_001376677.1 → NP_001363606.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 9, 10, and 12-16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    10. NM_001376678.1 → NP_001363607.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 9-11 and 13-16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    11. NM_001376679.1 → NP_001363608.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 9-12 and 14-16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    12. NM_001376680.1 → NP_001363609.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 9-13, 15, and 16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    13. NM_001376681.1 → NP_001363610.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 9-14 and 16, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    14. NM_001376682.1 → NP_001363611.1  clathrin coat assembly protein AP180 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 9-15, encodes isoform g.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:593 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    15. NM_001376683.1 → NP_001363612.1  clathrin coat assembly protein AP180 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform h.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 894
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    16. NM_001376684.1 → NP_001363613.1  clathrin coat assembly protein AP180 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform h.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 894
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    17. NM_001376685.1 → NP_001363614.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 21-26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    18. NM_001376686.1 → NP_001363615.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 20 and 22-26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    19. NM_001376687.1 → NP_001363616.1  clathrin coat assembly protein AP180 isoform gg

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:588 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    20. NM_001376688.1 → NP_001363617.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 20, 21, and 23-26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    21. NM_001376689.1 → NP_001363618.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 20-22 and 24-26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    22. NM_001376690.1 → NP_001363619.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variants 20-23, 25, and 26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    23. NM_001376691.1 → NP_001363620.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variants 20-24 and 26, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    24. NM_001376692.1 → NP_001363621.1  clathrin coat assembly protein AP180 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variants 20-25, encodes isoform i.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 890
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    25. NM_001376693.1 → NP_001363622.1  clathrin coat assembly protein AP180 isoform j

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:586 → 888
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    26. NM_001376694.1 → NP_001363623.1  clathrin coat assembly protein AP180 isoform k

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:717 → 887
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    27. NM_001376695.1 → NP_001363624.1  clathrin coat assembly protein AP180 isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29), as well as variants 30-32, encodes isoform l.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:579 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    28. NM_001376696.1 → NP_001363625.1  clathrin coat assembly protein AP180 isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30), as well as variants 29, 31, and 32, encodes isoform l.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:579 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    29. NM_001376697.1 → NP_001363626.1  clathrin coat assembly protein AP180 isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31), as well as variants 29, 30, and 32, encodes isoform l.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:579 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    30. NM_001376698.1 → NP_001363627.1  clathrin coat assembly protein AP180 isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32), as well as variants 29-31, encodes isoform l.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:579 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    31. NM_001376699.1 → NP_001363628.1  clathrin coat assembly protein AP180 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33), as well as variant 34, encodes isoform m.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 880
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    32. NM_001376700.1 → NP_001363629.1  clathrin coat assembly protein AP180 isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34), as well as variant 33, encodes isoform m.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:669 → 880
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    33. NM_001376701.1 → NP_001363630.1  clathrin coat assembly protein AP180 isoform n

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:655 → 876
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    34. NM_001376702.1 → NP_001363631.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36), as well as variants 37-41, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    35. NM_001376703.1 → NP_001363632.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37), as well as variants 36 and 38-41, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    36. NM_001376704.1 → NP_001363633.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38), as well as variants 36, 37, and 39-41, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    37. NM_001376705.1 → NP_001363634.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39), as well as variants 36-38, 40, and 41, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    38. NM_001376706.1 → NP_001363635.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (40), as well as variants 36-39 and 41, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    39. NM_001376707.1 → NP_001363636.1  clathrin coat assembly protein AP180 isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (41), as well as variants 36-40, encodes isoform o.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:567 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    40. NM_001376708.1 → NP_001363637.1  clathrin coat assembly protein AP180 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (42), as well as variants 4 and 43-45, encodes isoform b.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56438.1
      Conserved Domains (2) summary
      PHA03247
      Location:697 → 867
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    41. NM_001376709.1 → NP_001363638.1  clathrin coat assembly protein AP180 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (43), as well as variants 4, 42, 44, and 45, encodes isoform b.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56438.1
      Conserved Domains (2) summary
      PHA03247
      Location:697 → 867
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    42. NM_001376710.1 → NP_001363639.1  clathrin coat assembly protein AP180 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (44), as well as variants 4, 42, 43, and 45, encodes isoform b.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56438.1
      Conserved Domains (2) summary
      PHA03247
      Location:697 → 867
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    43. NM_001376711.1 → NP_001363640.1  clathrin coat assembly protein AP180 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (45), as well as variants 4 and 42-44, encodes isoform b.
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS56438.1
      Conserved Domains (2) summary
      PHA03247
      Location:697 → 867
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    44. NM_001376712.1 → NP_001363641.1  clathrin coat assembly protein AP180 isoform hh

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:588 → 872
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    45. NM_001376713.1 → NP_001363642.1  clathrin coat assembly protein AP180 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (47), as well as variant 48, encodes isoform p.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:643 → 864
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    46. NM_001376714.1 → NP_001363643.1  clathrin coat assembly protein AP180 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (48), as well as variant 47, encodes isoform p.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:643 → 864
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    47. NM_001376715.1 → NP_001363644.1  clathrin coat assembly protein AP180 isoform q

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:638 → 859
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:15 → 252
      ANTH; ANTH domain

    48. NM_001376716.1 → NP_001363645.1  clathrin coat assembly protein AP180 isoform r

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:553 → 855
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    49. NM_001376717.1 → NP_001363646.1  clathrin coat assembly protein AP180 isoform s

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:629 → 850
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    50. NM_001376718.1 → NP_001363647.1  clathrin coat assembly protein AP180 isoform t

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:675 → 845
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    51. NM_001376719.1 → NP_001363648.1  clathrin coat assembly protein AP180 isoform u

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:671 → 841
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    52. NM_001376720.1 → NP_001363649.1  clathrin coat assembly protein AP180 isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (54), as well as variants 55-58, encodes isoform v.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:667 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 224
      ANTH; ANTH domain

    53. NM_001376721.1 → NP_001363650.1  clathrin coat assembly protein AP180 isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (55), as well as variants 54 and 56-58, encodes isoform v.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:667 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 224
      ANTH; ANTH domain

    54. NM_001376723.1 → NP_001363652.1  clathrin coat assembly protein AP180 isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (56), as well as variants 54, 55, 57, and 58, encodes isoform v.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:667 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 224
      ANTH; ANTH domain

    55. NM_001376726.1 → NP_001363655.1  clathrin coat assembly protein AP180 isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (57), as well as variants 54-56 and 58, encodes isoform v.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:667 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 224
      ANTH; ANTH domain

    56. NM_001376728.1 → NP_001363657.1  clathrin coat assembly protein AP180 isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (58), as well as variants 54-57, encodes isoform v.
      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:667 → 837
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 224
      ANTH; ANTH domain

    57. NM_001376731.1 → NP_001363660.1  clathrin coat assembly protein AP180 isoform w

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:615 → 836
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    58. NM_001376733.1 → NP_001363662.1  clathrin coat assembly protein AP180 isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (60), as well as variant 61, encodes isoform x.
      Source sequence(s)
      AL109915
      Conserved Domains (3) summary
      PHA03247
      Location:562 → 830
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:734 → 836
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    59. NM_001376734.1 → NP_001363663.1  clathrin coat assembly protein AP180 isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (61), as well as variant 60, encodes isoform x.
      Source sequence(s)
      AL109915
      Conserved Domains (3) summary
      PHA03247
      Location:562 → 830
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:734 → 836
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    60. NM_001376735.1 → NP_001363664.1  clathrin coat assembly protein AP180 isoform y

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:611 → 832
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:1 → 225
      ANTH; ANTH domain

    61. NM_001376736.1 → NP_001363665.1  clathrin coat assembly protein AP180 isoform z

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:657 → 827
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    62. NM_001376737.1 → NP_001363666.1  clathrin coat assembly protein AP180 isoform aa

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:588 → 816
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    63. NM_001376738.1 → NP_001363667.1  clathrin coat assembly protein AP180 isoform bb

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:490 → 660
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    64. NM_001376739.1 → NP_001363668.1  clathrin coat assembly protein AP180 isoform cc

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (2) summary
      PHA03247
      Location:476 → 646
      PHA03247; large tegument protein UL36; Provisional
      pfam07651
      Location:24 → 269
      ANTH; ANTH domain

    65. NM_001376740.1 → NP_001363669.1  clathrin coat assembly protein AP180 isoform dd

      Status: VALIDATED

      Source sequence(s)
      AL109915
      UniProtKB/TrEMBL
      E5RGY9
      Conserved Domains (1) summary
      pfam07651
      Location:21 → 282
      ANTH; ANTH domain

    66. NM_001376741.1 → NP_001363670.1  clathrin coat assembly protein AP180 isoform ee

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    67. NM_001376742.1 → NP_001363671.1  clathrin coat assembly protein AP180 isoform ff

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 283
      ANTH; ANTH domain

    68. NM_014841.3 → NP_055656.1  clathrin coat assembly protein AP180 isoform a

      See identical proteins and their annotated locations for NP_055656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AL109915
      Consensus CDS
      CCDS47455.1
      UniProtKB/Swiss-Prot
      A8K0L7, E5RI02, O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7
      Related
      ENSP00000400459.2, ENST00000439399.6
      Conserved Domains (2) summary
      pfam07651
      Location:21 → 284
      ANTH; ANTH domain
      cl26464
      Location:595 → 897
      Atrophin-1; Atrophin-1 family

    RNA

    1. NR_164843.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109915

    2. NR_164844.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109915

    3. NR_164845.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109915

    4. NR_164846.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL109915
      Related
      ENST00000518312.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      83552885..83709393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      84776120..84932636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_026669.1: Suppressed sequence

      Description
      NR_026669.1: This RefSeq was permanently suppressed because it is now thought that this transcript does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60641.2 GenPept UniProtKB/Swiss-Prot:O60641

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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