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    CD37 CD37 molecule [ Homo sapiens (human) ]

    Gene ID: 951, updated on 29-Oct-2024

    Summary

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    Official Symbol
    CD37provided by HGNC
    Official Full Name
    CD37 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1666
    See related
    Ensembl:ENSG00000104894 MIM:151523; AllianceGenome:HGNC:1666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP52-40; TSPAN26
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lymph node (RPKM 111.7), spleen (RPKM 99.3) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD37 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49335406..49340606)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52332834..52338034)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49838663..49843863)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49816848-49817070 Neighboring gene microRNA 4324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14931 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49830555-49830706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49842721-49843696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14936 Neighboring gene TEA domain transcription factor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49863002-49863502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49864048-49864757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49864758-49865466 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene KASH domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14937 Neighboring gene uncharacterized LOC124904740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918083-49918637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918638-49919191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Angelisová P, et al. Immunogenetics, 1994. PMID 8119731
    2. Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Zhao X, et al. Blood, 2007 Oct 1. PMID 17440052, Free PMC Article
    3. Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies. Rafiq S, et al. MAbs, 2013 Sep-Oct. PMID 23883821, Free PMC Article
    4. AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML. Pereira DS, et al. Mol Cancer Ther, 2015 Jul. PMID 25934707, Free PMC Article
    5. Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma. Xu-Monette ZY, et al. Blood, 2016 Dec 29. PMID 27760757, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD20 expression regulates CD37 levels in B-cell lymphoma - implications for immunotherapies.
      Title: CD20 expression regulates CD37 levels in B-cell lymphoma - implications for immunotherapies.
    2. CD37 expression in follicular lymphoma.
      Title: CD37 expression in follicular lymphoma.
    3. CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia.
      Title: CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia.
    4. From a cohort of 137 primary diffuse large B-cell lymphoma (DLBCL) samples. CD37 mutations were exclusively identified in immune-privileged site-associated DLBCL (IP-DLBCL) cases but absent in non-IP-DLBCL cases. Modeling and functional analysis of CD37 missense mutations revealed loss of function by impaired CD37 protein expression at the plasma membrane of human lymphoma B cells.
      Title: High frequency of inactivating tetraspanin C D37 mutations in diffuse large B-cell lymphoma at immune-privileged sites.
    5. The anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia.
      Title: Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia.
    6. tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration.
      Title: C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
    7. Low CD37 expression is associated with brain metastasis in lung cancer.
      Title: Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.
    8. CD37 is highly expressed in human lymphoma.
      Title: Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas.
    9. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma.
      Title: Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
    10. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML).
      Title: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD37 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Nef PubMed
    nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed
    Vpu vpu Human CD37 is relocalized from plasma membrane to a perinuclear area in the presence of HIV-1 Vpu PubMed
    vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD37 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC120234

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte antigen CD37
    Names
    cell differentiation antigen 37
    leukocyte surface antigen CD37
    tetraspanin-26
    tspan-26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033941.1 RefSeqGene

      Range
      4987..10187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040031.2 → NP_001035120.1  leukocyte antigen CD37 isoform B

      See identical proteins and their annotated locations for NP_001035120.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (B) has a shorter N-terminus, compared to isoform A.
      Source sequence(s)
      AA767248, AC010524, AC011450
      Consensus CDS
      CCDS46139.1
      UniProtKB/Swiss-Prot
      P11049
      Related
      ENSP00000413151.1, ENST00000426897.6
      Conserved Domains (2) summary
      cd03160
      Location:40 → 175
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:1 → 202
      Tetraspannin; Tetraspanin family

    2. NM_001774.3 → NP_001765.1  leukocyte antigen CD37 isoform A

      See identical proteins and their annotated locations for NP_001765.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AA767248, AC010524, AC011450, BP309557
      Consensus CDS
      CCDS12760.1
      UniProtKB/Swiss-Prot
      B4DVC1, P11049, Q3KPF9
      UniProtKB/TrEMBL
      B7ZAN3
      Related
      ENSP00000325708.3, ENST00000323906.9
      Conserved Domains (2) summary
      cd03160
      Location:108 → 243
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:26 → 270
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49335406..49340606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259435.4 → XP_005259492.1  leukocyte antigen CD37 isoform X1

      Conserved Domains (2) summary
      cd03160
      Location:108 → 243
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:26 → 269
      Tetraspannin; Tetraspanin family

    2. XM_011527542.4 → XP_011525844.1  leukocyte antigen CD37 isoform X2

      See identical proteins and their annotated locations for XP_011525844.1

      UniProtKB/TrEMBL
      M0QZP6
      Conserved Domains (2) summary
      cd03160
      Location:40 → 175
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:1 → 201
      Tetraspannin; Tetraspanin family

    3. XM_011527543.4 → XP_011525845.1  leukocyte antigen CD37 isoform X2

      See identical proteins and their annotated locations for XP_011525845.1

      UniProtKB/TrEMBL
      M0QZP6
      Related
      ENSP00000470683.1, ENST00000594743.1
      Conserved Domains (2) summary
      cd03160
      Location:40 → 175
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:1 → 201
      Tetraspannin; Tetraspanin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52332834..52338034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322710.1 → XP_054178685.1  leukocyte antigen CD37 isoform X1

    2. XM_054322711.1 → XP_054178686.1  leukocyte antigen CD37 isoform X2

    3. XM_054322714.1 → XP_054178689.1  leukocyte antigen CD37 isoform X3

    4. XM_054322712.1 → XP_054178687.1  leukocyte antigen CD37 isoform X2

    5. XM_054322713.1 → XP_054178688.1  leukocyte antigen CD37 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11049.2 GenPept UniProtKB/Swiss-Prot:P11049

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