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    Dusp22 dual specificity phosphatase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361242, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dusp22provided by RGD
    Official Full Name
    dual specificity phosphatase 22provided by RGD
    Primary source
    RGD:1307146
    See related
    EnsemblRapid:ENSRNOG00000056376 AllianceGenome:RGD:1307146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine kinase binding activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within several processes, including negative regulation of T cell mediated immunity; negative regulation of T cell receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and leading edge of lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and plasma membrane. Orthologous to human DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 126.9), Heart (RPKM 98.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp22 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (33989637..34040021, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (33780980..33831241, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (34986589..35037297, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 4 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene uncharacterized LOC108348556 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 Neighboring gene glycogenin 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. Li JP, et al. J Biol Chem, 2010 Feb 19. PMID 20018849, Free PMC Article
    2. Regulation of STAT3-mediated signaling by LMW-DSP2. Sekine Y, et al. Oncogene, 2006 Sep 21. PMID 16636663
    3. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Li JP, et al. Nat Commun, 2014 Apr 9. PMID 24714587
    4. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. Chen AJ, et al. J Biol Chem, 2002 Sep 27. PMID 12138158
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in leading edge of lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 22
    NP_001101882.1
    NP_001386177.1
    XP_006253950.1
    XP_017456091.2
    XP_017456092.2
    XP_038951812.1
    XP_063132659.1
    XP_063132660.1
    XP_063132661.1
    XP_063132662.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108412.2 → NP_001101882.1  dual specificity protein phosphatase 22 isoform 1

      See identical proteins and their annotated locations for NP_001101882.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J7L5
      Conserved Domains (1) summary
      cd14581
      Location:2 → 150
      DUSP22; dual specificity protein phosphatase 22

    2. NM_001399248.2 → NP_001386177.1  dual specificity protein phosphatase 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AGY7, A6J7L7
      Related
      ENSRNOP00000092639.1, ENSRNOT00000094585.2
      Conserved Domains (1) summary
      cd14581
      Location:2 → 150
      DUSP22; dual specificity protein phosphatase 22

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      33989637..34040021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276590.1 → XP_063132660.1  dual specificity protein phosphatase 22 isoform X6

    2. XM_063276591.1 → XP_063132661.1  dual specificity protein phosphatase 22 isoform X7

    3. XM_006253888.4 → XP_006253950.1  dual specificity protein phosphatase 22 isoform X2

      Conserved Domains (1) summary
      cd00127
      Location:1 → 136
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    4. XM_063276589.1 → XP_063132659.1  dual specificity protein phosphatase 22 isoform X4

      Related
      ENSRNOP00000071916.3, ENSRNOT00000090946.3

    5. XM_039095884.2 → XP_038951812.1  dual specificity protein phosphatase 22 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:13 → 152
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_017600602.3 → XP_017456091.2  dual specificity protein phosphatase 22 isoform X1

      Conserved Domains (1) summary
      cd14581
      Location:13 → 156
      DUSP22; dual specificity protein phosphatase 22

    7. XM_017600603.3 → XP_017456092.2  dual specificity protein phosphatase 22 isoform X3

      UniProtKB/TrEMBL
      D3ZC16
      Conserved Domains (1) summary
      cd14581
      Location:13 → 156
      DUSP22; dual specificity protein phosphatase 22

    8. XM_063276592.1 → XP_063132662.1  dual specificity protein phosphatase 22 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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