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    Dusp16 dual specificity phosphatase 16 [ Mus musculus (house mouse) ]

    Gene ID: 70686, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dusp16provided by MGI
    Official Full Name
    dual specificity phosphatase 16provided by MGI
    Primary source
    MGI:MGI:1917936
    See related
    Ensembl:ENSMUSG00000030203 AllianceGenome:MGI:1917936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MKP7; Mkpm; MKP-7; D6Ertd213e; 3830417M17Rik
    Summary
    Predicted to enable phosphoprotein phosphatase activity; protein carrier chaperone; and protein kinase binding activity. Predicted to be involved in dephosphorylation; negative regulation of MAPK cascade; and signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP16 (dual specificity phosphatase 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 11.4), mammary gland adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dusp16 in Genome Data Viewer
    Location:
    6 G1; 6 65.77 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134692431..134769687, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134715468..134807063, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:134565289-134565590 Neighboring gene MANSC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9105 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene predicted gene, 57779 Neighboring gene STARR-seq mESC enhancer starr_17547 Neighboring gene predicted gene, 36328 Neighboring gene RIKEN cDNA 1700055D16 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134742531-134742832 Neighboring gene STARR-positive B cell enhancer ABC_E3688 Neighboring gene predicted gene, 53343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:134779903-134780086 Neighboring gene cAMP responsive element binding protein-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. Berdichevsky A, et al. J Biol Chem, 2010 Jul 9. PMID 20430894, Free PMC Article
    2. MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression. Zhang Y, et al. J Immunol, 2015 Apr 1. PMID 25716993, Free PMC Article
    3. Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation. Musikacharoen T, et al. J Biol Chem, 2011 Jul 15. PMID 21613215, Free PMC Article
    4. A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines. Matsuguchi T, et al. Mol Cell Biol, 2001 Oct. PMID 11564882, Free PMC Article
    5. miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7. Du WW, et al. Cell Death Dis, 2014 Jul 31. PMID 25077541, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.
      Title: Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.
    2. Studies in knockout mice show that DUSP16 is an endogenous regulator of OPN-type osteoblast differentiation, via JNK dephosphorylation by DUSP16.
      Title: JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).
    3. Ablation of Dusp16 enhanced axonal degeneration in response to trophic withdrawal, suggesting that it has a protective function. Moreover, axonal skin innervation was severely reduced while neuronal elimination was increased in the Dusp16 knockout. Mechanistically, Dusp16 negatively regulates the transcription factor p53 and antagonizes the expression of the pro-degenerative factor, Puma.
      Title: Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors.
    4. MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression.
      Title: MAPK phosphatase 7 regulates T cell differentiation via inhibiting ERK-mediated IL-2 expression.
    5. ADCY5 repression by miR-17 facilitated the translocation of EGFR and MKP7 from membrane into cytoplasmic and mitochondrial fractions.
      Title: miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.
    6. Production of IL-10 and its inhibitory effect on IL-12 production were unaltered in Dusp16tp/tp macrophages.
      Title: Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.
    7. the functional role of DUSP16 in Th1/Th2 balance.
      Title: Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation.
    8. the contrasting effects of acute and chronic stress on insulin sensitivity are driven by changes in subcellular distribution of MKP7 and activated JNK
      Title: Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK.
    9. DUSP16 is an important regulator of JNK activity and effector functions of CD4 and CD8 T cells.
      Title: Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells.
    10. JIP-1 targets MKP-7 to dephosphorylate JNK.
      Title: The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase p38 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein carrier chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 16
    Names
    MAP kinase phosphatase-7
    map kinase phosphatase-M
    NP_001041519.1
    NP_569714.2
    XP_036008191.1
    XP_036008192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048054.2 → NP_001041519.1  dual specificity protein phosphatase 16 isoform B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B1) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A1. It encodes isoform B1, which lacks an internal segment and is shorter, compared to isoform A1.
      Source sequence(s)
      AC122193, AC126692, BE851024, CA751341, CF733313, CN695929, CV557369
      Consensus CDS
      CCDS85175.1
      UniProtKB/TrEMBL
      F6UIK0, Q3UMM5
      Related
      ENSMUSP00000115925.3, ENSMUST00000129433.4
      Conserved Domains (2) summary
      cd00127
      Location:158 → 272
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    2. NM_130447.3 → NP_569714.2  dual specificity protein phosphatase 16 isoform A1

      See identical proteins and their annotated locations for NP_569714.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A1) represents the longer transcript and encodes the longer isoform (A1).
      Source sequence(s)
      AC122193, AC126692, BC057321
      Consensus CDS
      CCDS39679.1
      UniProtKB/TrEMBL
      Q6PCP3, Q920R2
      Related
      ENSMUSP00000098419.4, ENSMUST00000100857.10
      Conserved Domains (2) summary
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cl28904
      Location:157 → 301
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134692431..134769687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152299.1 → XP_036008192.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/TrEMBL
      Q6PCP3, Q920R2
      Conserved Domains (2) summary
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cl28904
      Location:157 → 301
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_036152298.1 → XP_036008191.1  dual specificity protein phosphatase 16 isoform X1

      UniProtKB/TrEMBL
      Q6PCP3, Q920R2
      Conserved Domains (2) summary
      cd01446
      Location:10 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cl28904
      Location:157 → 301
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181320.2: Suppressed sequence

      Description
      NM_181320.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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