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    EAP1 Eap1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853631, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EAP1
    Official Full Name
    Eap1p
    Primary source
    SGD:S000001687
    Locus tag
    YKL204W
    See related
    AllianceGenome:SGD:S000001687; FungiDB:YKL204W; VEuPathDB:YKL204W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables eukaryotic initiation factor 4E binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in cytoplasmic stress granule. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EAP1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (53704..55602)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Add66p Neighboring gene Ran GTPase-binding protein LOS1 Neighboring gene phosphatidylinositol kinase-related protein kinase TOR2 Neighboring gene Mnn4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of translation initiation by the yeast eIF4E binding proteins is required for the pseudohyphal response. Ibrahimo S, et al. Yeast, 2006 Oct-Nov. PMID 17083129
    2. Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Cosentino GP, et al. Mol Cell Biol, 2000 Jul. PMID 10848587, Free PMC Article
    3. The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation. Matsuo R, et al. FEBS Lett, 2005 Apr 25. PMID 15848184
    4. Genetic and biochemical interactions between SCP160 and EAP1 in yeast. Mendelsohn BA, et al. Nucleic Acids Res, 2003 Oct 15. PMID 14530432, Free PMC Article
    5. eIF4E-binding protein regulation of mRNAs with differential 5'-UTR secondary structure: a polyelectrostatic model for a component of protein-mRNA interactions. Cawley A, et al. Nucleic Acids Res, 2012 Sep. PMID 22718971, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr4.
      Title: The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr4.
    2. Crystal structures of the yeast eIF4E bound to Eap1p were determined.The canonical and non-canonical motifs in 4E-BPs and eIF4G contribute differently to the affinity for eIF4E.
      Title: Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
    3. the interaction of Vts1p with Eap1p at target mRNAs stimulates decapping and transcript decay
      Title: The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay.
    4. SESA network comprising Smy2, Eap1, Scp160 and Asc1 , specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex
      Title: The SESA network links duplication of the yeast centrosome with the protein translation machinery.
    5. upon TOR-inactivation, the putative TOR-regulated eIF4E-associated protein Eap1p likely functions downstream of Gcn2p to attenuate GCN4 translation via a mechanism independent of eIF4E-binding
      Title: The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Eap1p
    NP_012718.1
    • eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      53704..55602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179769.1 → NP_012718.1  TPA: Eap1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWZ9, P36041
      UniProtKB/TrEMBL
      B3LQQ5, B5VLW2, C8ZBX5, G2WHJ0, N1P0E6
      Conserved Domains (1) summary
      TIGR01628
      Location:555 → 622
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36041.1

    Gene LinkOut

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