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    Ccar1 cell division cycle and apoptosis regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361849, updated on 2-Nov-2024

    Summary

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    Symbol
    Ccar1provided by RGD
    Full Name
    cell division cycle and apoptosis regulator 1provided by RGD
    Primary source
    RGD:1560358
    See related
    EnsemblRapid:ENSRNOG00000000397 AllianceGenome:RGD:1560358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560358
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 90.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccar1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31228624..31271233, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30685916..30728531, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32373443..32416044, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene uncharacterized LOC108349068 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene uncharacterized LOC120098953 Neighboring gene vacuolar protein sorting 36, pseudogene 1 Neighboring gene radial spoke head component 4A Neighboring gene lysyl-tRNA synthetase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. Seo WY, et al. Nucleic Acids Res, 2013 Oct. PMID 23887938, Free PMC Article
    2. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. Rishi AK, et al. J Biol Chem, 2003 Aug 29. PMID 12816952
    3. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Kim JH, et al. Mol Cell, 2008 Aug 22. PMID 18722177, Free PMC Article
    4. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Mizuta S, et al. Genes Cells, 2014 Jan. PMID 24245781, Free PMC Article
    5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle and apoptosis regulator protein 1
    Names
    cell division cycle and apoptosis regulator protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108535.1 → NP_001102005.1  cell division cycle and apoptosis regulator protein 1

      See identical proteins and their annotated locations for NP_001102005.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474016
      UniProtKB/TrEMBL
      A0A8I6A183, A6K465
      Related
      ENSRNOP00000085003.1, ENSRNOT00000097504.2
      Conserved Domains (6) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PHA03356
      Location:278 → 310
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:922 → 988
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:479 → 598
      DBC1; DBC1
      pfam14444
      Location:149 → 201
      S1-like; S1-like
      cl01797
      Location:935 → 1099
      DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      31228624..31271233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279307.1 → XP_063135377.1  cell division cycle and apoptosis regulator protein 1 isoform X3

    2. XM_063279308.1 → XP_063135378.1  cell division cycle and apoptosis regulator protein 1 isoform X4

    3. XM_063279306.1 → XP_063135376.1  cell division cycle and apoptosis regulator protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K465

    4. XM_006256463.4 → XP_006256525.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006256525.1

      UniProtKB/TrEMBL
      A0A8I6A183, D4A2P1
      Conserved Domains (6) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PHA03356
      Location:278 → 310
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:931 → 997
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:479 → 598
      DBC1; DBC1
      pfam14444
      Location:149 → 201
      S1-like; S1-like
      cl01797
      Location:944 → 1108
      DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

    5. XM_063279311.1 → XP_063135381.1  cell division cycle and apoptosis regulator protein 1 isoform X6

    6. XM_039098883.2 → XP_038954811.1  cell division cycle and apoptosis regulator protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A183
      Conserved Domains (5) summary
      smart00513
      Location:619 → 652
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:169 → 288
      PRK10927; cell division protein FtsN
      pfam14443
      Location:461 → 586
      DBC1
      pfam14444
      Location:130 → 186
      S1-like
      pfam15905
      Location:1033 → 1138
      HMMR_N; Hyaluronan mediated motility receptor N-terminal

    7. XM_006256464.5 → XP_006256526.1  cell division cycle and apoptosis regulator protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A183
      Conserved Domains (5) summary
      PHA03356
      Location:278 → 310
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:869 → 935
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:479 → 598
      DBC1; DBC1
      pfam14444
      Location:149 → 201
      S1-like; S1-like
      cl01797
      Location:882 → 1046
      DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

    8. XM_006256462.4 → XP_006256524.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006256524.1

      UniProtKB/TrEMBL
      A0A8I6A183, D4A2P1
      Related
      ENSRNOP00000059432.3, ENSRNOT00000067004.4
      Conserved Domains (6) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PHA03356
      Location:278 → 310
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:931 → 997
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:479 → 598
      DBC1; DBC1
      pfam14444
      Location:149 → 201
      S1-like; S1-like
      cl01797
      Location:944 → 1108
      DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

    9. XM_063279309.1 → XP_063135379.1  cell division cycle and apoptosis regulator protein 1 isoform X4

    10. XM_008772894.3 → XP_008771116.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008771116.1

      UniProtKB/TrEMBL
      A0A8I6A183, D4A2P1
      Conserved Domains (6) summary
      smart00513
      Location:634 → 667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PHA03356
      Location:278 → 310
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:931 → 997
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:479 → 598
      DBC1; DBC1
      pfam14444
      Location:149 → 201
      S1-like; S1-like
      cl01797
      Location:944 → 1108
      DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

    11. XM_063279305.1 → XP_063135375.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A2P1

    12. XM_063279304.1 → XP_063135374.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A2P1

    13. XM_063279310.1 → XP_063135380.1  cell division cycle and apoptosis regulator protein 1 isoform X5

    14. XM_063279303.1 → XP_063135373.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A2P1

    15. XM_008772897.4 → XP_008771119.1  cell division cycle and apoptosis regulator protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A183
      Conserved Domains (4) summary
      smart00513
      Location:442 → 475
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PHA03356
      Location:86 → 118
      PHA03356; tegument protein UL11; Provisional
      pfam13499
      Location:739 → 805
      EF-hand_7; EF-hand domain pair
      pfam14443
      Location:287 → 406
      DBC1; DBC1
    Nucleotide Protein Strain
    Heading Accession and Version

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