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    Emsy EMSY transcriptional repressor, BRCA2 interacting [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361607, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Emsyprovided by RGD
    Official Full Name
    EMSY transcriptional repressor, BRCA2 interactingprovided by RGD
    Primary source
    RGD:1310712
    See related
    EnsemblRapid:ENSRNOG00000015560 AllianceGenome:RGD:1310712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310712
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleoplasm. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 61.6), Heart (RPKM 56.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Emsy in Genome Data Viewer
    Location:
    1q32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162295167..162364742, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152881485..152960420, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163541071..163618576, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C, pseudogene 2 Neighboring gene uncharacterized LOC134484908 Neighboring gene uncharacterized LOC134483759 Neighboring gene THAP domain containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. Ekblad CM, et al. EMBO Rep, 2005 Jul. PMID 15947784, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BRCA2-interacting transcriptional repressor EMSY
    Names
    EMSY BRCA2-interacting transcriptional repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400843.1 → NP_001387772.1  BRCA2-interacting transcriptional repressor EMSY

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ATJ6, D4AC97
      Related
      ENSRNOP00000079335.2, ENSRNOT00000120187.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      162295167..162364742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267144.1 → XP_063123214.1  BRCA2-interacting transcriptional repressor EMSY isoform X29

    2. XM_063267115.1 → XP_063123185.1  BRCA2-interacting transcriptional repressor EMSY isoform X21

      UniProtKB/TrEMBL
      D4AC97

    3. XM_039101098.2 → XP_038957026.1  BRCA2-interacting transcriptional repressor EMSY isoform X34

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 59
      ENT; ENT domain
      NF033645
      Location:934 → 1081
      pilus_FilE; putative pilus assembly protein FilE

    4. XM_039101095.2 → XP_038957023.1  BRCA2-interacting transcriptional repressor EMSY isoform X13

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 59
      ENT; ENT domain
      NF033645
      Location:948 → 1095
      pilus_FilE; putative pilus assembly protein FilE

    5. XM_017590189.3 → XP_017445678.1  BRCA2-interacting transcriptional repressor EMSY isoform X6

      UniProtKB/TrEMBL
      D4AC97
      Related
      ENSRNOP00000040421.6, ENSRNOT00000043788.8

    6. XM_063267148.1 → XP_063123218.1  BRCA2-interacting transcriptional repressor EMSY isoform X31

    7. XM_063267141.1 → XP_063123211.1  BRCA2-interacting transcriptional repressor EMSY isoform X28

    8. XM_063267113.1 → XP_063123183.1  BRCA2-interacting transcriptional repressor EMSY isoform X19

      UniProtKB/TrEMBL
      D4AC97

    9. XM_063267137.1 → XP_063123207.1  BRCA2-interacting transcriptional repressor EMSY isoform X27

      UniProtKB/TrEMBL
      D4AC97

    10. XM_039101099.2 → XP_038957027.1  BRCA2-interacting transcriptional repressor EMSY isoform X25

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      PRK03427
      Location:955 → 1068
      PRK03427; cell division protein ZipA; Provisional
      pfam03735
      Location:19 → 85
      ENT; ENT domain

    11. XM_039101097.2 → XP_038957025.1  BRCA2-interacting transcriptional repressor EMSY isoform X12

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 85
      ENT; ENT domain
      NF033645
      Location:959 → 1106
      pilus_FilE; putative pilus assembly protein FilE

    12. XM_063267128.1 → XP_063123198.1  BRCA2-interacting transcriptional repressor EMSY isoform X24

      UniProtKB/TrEMBL
      D4AC97

    13. XM_039101094.2 → XP_038957022.1  BRCA2-interacting transcriptional repressor EMSY isoform X10

      UniProtKB/TrEMBL
      A0A8I5YCB7, D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 85
      ENT; ENT domain
      NF033645
      Location:973 → 1120
      pilus_FilE; putative pilus assembly protein FilE

    14. XM_039101092.2 → XP_038957020.1  BRCA2-interacting transcriptional repressor EMSY isoform X5

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 85
      ENT; ENT domain
      NF033645
      Location:1023 → 1170
      pilus_FilE; putative pilus assembly protein FilE

    15. XM_006229805.5 → XP_006229867.1  BRCA2-interacting transcriptional repressor EMSY isoform X4

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 85
      ENT; ENT domain

    16. XM_063267146.1 → XP_063123216.1  BRCA2-interacting transcriptional repressor EMSY isoform X30

    17. XM_063267093.1 → XP_063123163.1  BRCA2-interacting transcriptional repressor EMSY isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZY83
      Related
      ENSRNOP00000082935.2, ENSRNOT00000098402.2

    18. XM_063267101.1 → XP_063123171.1  BRCA2-interacting transcriptional repressor EMSY isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZN84, D4AC97

    19. XM_063267121.1 → XP_063123191.1  BRCA2-interacting transcriptional repressor EMSY isoform X23

      UniProtKB/TrEMBL
      D4AC97

    20. XM_006229808.5 → XP_006229870.1  BRCA2-interacting transcriptional repressor EMSY isoform X8

      UniProtKB/TrEMBL
      A0A8I6AMY7, D4AC97
      Related
      ENSRNOP00000094017.1, ENSRNOT00000117742.2
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    21. XM_039101091.2 → XP_038957019.1  BRCA2-interacting transcriptional repressor EMSY isoform X2

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain
      NF033645
      Location:1037 → 1184
      pilus_FilE; putative pilus assembly protein FilE

    22. XM_063267084.1 → XP_063123154.1  BRCA2-interacting transcriptional repressor EMSY isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZY83

    23. XM_063267114.1 → XP_063123184.1  BRCA2-interacting transcriptional repressor EMSY isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZY83

    24. XM_006229807.5 → XP_006229869.1  BRCA2-interacting transcriptional repressor EMSY isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZY83
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    25. XM_063267133.1 → XP_063123203.1  BRCA2-interacting transcriptional repressor EMSY isoform X26

    26. XM_006229810.5 → XP_006229872.1  BRCA2-interacting transcriptional repressor EMSY isoform X15

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    27. XM_006229809.5 → XP_006229871.1  BRCA2-interacting transcriptional repressor EMSY isoform X11

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    28. XM_039101096.2 → XP_038957024.1  BRCA2-interacting transcriptional repressor EMSY isoform X18

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (2) summary
      PRK03427
      Location:1020 → 1133
      PRK03427; cell division protein ZipA; Provisional
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    29. XM_006229804.5 → XP_006229866.1  BRCA2-interacting transcriptional repressor EMSY isoform X3

      UniProtKB/TrEMBL
      D4AC97
      Related
      ENSRNOP00000097921.2, ENSRNOT00000112537.2
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    30. XM_006229811.5 → XP_006229873.1  BRCA2-interacting transcriptional repressor EMSY isoform X16

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    31. XM_006229802.5 → XP_006229864.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain

    32. XM_063267155.1 → XP_063123225.1  BRCA2-interacting transcriptional repressor EMSY isoform X32

    33. XM_063267156.1 → XP_063123226.1  BRCA2-interacting transcriptional repressor EMSY isoform X33

    34. XM_006229812.5 → XP_006229874.1  BRCA2-interacting transcriptional repressor EMSY isoform X22

      UniProtKB/TrEMBL
      D4AC97
      Conserved Domains (1) summary
      pfam03735
      Location:19 → 81
      ENT; ENT domain
    Nucleotide Protein Strain
    Heading Accession and Version

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